Manganese in PDB 7lf2: Trimeric Human Arginase 1 in Complex with MAB4

All present enzymatic activity of Trimeric Human Arginase 1 in Complex with MAB4:
3.5.3.1;

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 12;

Binding sites:

The binding sites of Manganese atom in the Trimeric Human Arginase 1 in Complex with MAB4 (pdb code 7lf2). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total 12 binding sites of Manganese where determined in the Trimeric Human Arginase 1 in Complex with MAB4, PDB code: 7lf2:
Jump to Manganese binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Manganese binding site 1 out of 12 in the Trimeric Human Arginase 1 in Complex with MAB4


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of Trimeric Human Arginase 1 in Complex with MAB4 within 5.0Å range: probe atom residue distance (Å) B Occ A:Mn1001 b:149.3 occ:1.00 MN A:MN1002 0.9 142.2 1.0 OD1 A:ASP124 2.0 120.2 1.0 OD2 A:ASP124 2.1 120.2 1.0 CE1 A:HIS101 2.1 128.2 1.0 OD2 A:ASP232 2.1 125.0 1.0 CG A:ASP124 2.1 120.2 1.0 ND1 A:HIS101 2.8 128.2 1.0 CG A:ASP232 3.1 125.0 1.0 NE2 A:HIS101 3.1 128.2 1.0 CB A:ASP124 3.5 120.2 1.0 OD2 A:ASP128 3.5 115.0 1.0 CB A:ASP232 3.5 125.0 1.0 OD1 A:ASP234 3.7 123.0 1.0 OD2 A:ASP234 3.9 123.0 1.0 CG A:HIS101 4.1 128.2 1.0 ND1 A:HIS126 4.1 113.5 1.0 CG A:ASP234 4.2 123.0 1.0 CD2 A:HIS101 4.2 128.2 1.0 CG A:ASP128 4.2 115.0 1.0 OD1 A:ASP232 4.2 125.0 1.0 OD1 A:ASP128 4.2 115.0 1.0 CB A:HIS126 4.4 113.5 1.0 CA A:ASP124 4.4 120.2 1.0 N A:HIS126 4.5 113.5 1.0 N A:ALA125 4.5 107.0 1.0 CG A:HIS126 4.7 113.5 1.0 CG A:GLU277 4.7 129.1 1.0 O A:HIS126 4.9 113.5 1.0 C A:ASP124 4.9 120.2 1.0 CA A:HIS126 4.9 113.5 1.0 NE1 A:TRP122 5.0 124.2 1.0 CA A:ASP232 5.0 125.0 1.0 CZ2 A:TRP122 5.0 124.2 1.0

Manganese binding site 2 out of 12 in the Trimeric Human Arginase 1 in Complex with MAB4


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 2 of Trimeric Human Arginase 1 in Complex with MAB4 within 5.0Å range: probe atom residue distance (Å) B Occ A:Mn1002 b:142.2 occ:1.00 MN A:MN1001 0.9 149.3 1.0 OD2 A:ASP232 1.9 125.0 1.0 OD1 A:ASP124 1.9 120.2 1.0 CG A:ASP124 2.5 120.2 1.0 OD2 A:ASP124 2.6 120.2 1.0 CE1 A:HIS101 2.8 128.2 1.0 CG A:ASP232 3.0 125.0 1.0 OD2 A:ASP234 3.1 123.0 1.0 OD1 A:ASP234 3.1 123.0 1.0 CG A:ASP234 3.4 123.0 1.0 ND1 A:HIS126 3.6 113.5 1.0 ND1 A:HIS101 3.6 128.2 1.0 CB A:ASP232 3.7 125.0 1.0 NE2 A:HIS101 3.8 128.2 1.0 CB A:ASP124 3.9 120.2 1.0 OD1 A:ASP232 4.0 125.0 1.0 OD2 A:ASP128 4.2 115.0 1.0 CB A:HIS126 4.3 113.5 1.0 N A:HIS126 4.3 113.5 1.0 N A:ALA125 4.3 107.0 1.0 CG A:HIS126 4.3 113.5 1.0 OG1 A:THR246 4.3 127.4 1.0 CE1 A:HIS126 4.5 113.5 1.0 CA A:ASP124 4.6 120.2 1.0 OD1 A:ASP128 4.6 115.0 1.0 CG A:GLU277 4.7 129.1 1.0 CG A:HIS101 4.8 128.2 1.0 CG A:ASP128 4.8 115.0 1.0 CD2 A:HIS101 4.9 128.2 1.0 CA A:HIS126 4.9 113.5 1.0 CB A:ASP234 4.9 123.0 1.0 C A:ASP124 4.9 120.2 1.0

Manganese binding site 3 out of 12 in the Trimeric Human Arginase 1 in Complex with MAB4


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 3 of Trimeric Human Arginase 1 in Complex with MAB4 within 5.0Å range: probe atom residue distance (Å) B Occ B:Mn1001 b:144.2 occ:1.00 MN B:MN1002 0.9 139.6 1.0 OD2 B:ASP124 2.1 118.1 1.0 OD1 B:ASP124 2.1 118.1 1.0 OD2 B:ASP232 2.1 122.1 1.0 CE1 B:HIS101 2.1 123.9 1.0 CG B:ASP124 2.2 118.1 1.0 ND1 B:HIS101 2.8 123.9 1.0 CG B:ASP232 3.1 122.1 1.0 NE2 B:HIS101 3.2 123.9 1.0 CB B:ASP124 3.5 118.1 1.0 OD2 B:ASP128 3.5 107.5 1.0 CB B:ASP232 3.5 122.1 1.0 OD1 B:ASP234 3.7 117.5 1.0 OD2 B:ASP234 3.9 117.5 1.0 CG B:HIS101 4.1 123.9 1.0 ND1 B:HIS126 4.1 105.7 1.0 OD1 B:ASP232 4.2 122.1 1.0 CG B:ASP234 4.2 117.5 1.0 CD2 B:HIS101 4.2 123.9 1.0 CG B:ASP128 4.3 107.5 1.0 OD1 B:ASP128 4.3 107.5 1.0 CB B:HIS126 4.4 105.7 1.0 CA B:ASP124 4.4 118.1 1.0 N B:HIS126 4.5 105.7 1.0 N B:ALA125 4.6 99.0 1.0 CG B:GLU277 4.6 127.9 1.0 CG B:HIS126 4.7 105.7 1.0 O B:HIS126 4.9 105.7 1.0 C B:ASP124 5.0 118.1 1.0 CA B:ASP232 5.0 122.1 1.0 CA B:HIS126 5.0 105.7 1.0

Manganese binding site 4 out of 12 in the Trimeric Human Arginase 1 in Complex with MAB4


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 4 of Trimeric Human Arginase 1 in Complex with MAB4 within 5.0Å range: probe atom residue distance (Å) B Occ B:Mn1002 b:139.6 occ:1.00 MN B:MN1001 0.9 144.2 1.0 OD2 B:ASP232 1.9 122.1 1.0 OD1 B:ASP124 1.9 118.1 1.0 CG B:ASP124 2.4 118.1 1.0 OD2 B:ASP124 2.6 118.1 1.0 CE1 B:HIS101 2.9 123.9 1.0 CG B:ASP232 3.0 122.1 1.0 OD1 B:ASP234 3.0 117.5 1.0 OD2 B:ASP234 3.1 117.5 1.0 CG B:ASP234 3.4 117.5 1.0 ND1 B:HIS126 3.6 105.7 1.0 ND1 B:HIS101 3.6 123.9 1.0 CB B:ASP232 3.7 122.1 1.0 NE2 B:HIS101 3.8 123.9 1.0 CB B:ASP124 3.8 118.1 1.0 OD1 B:ASP232 4.0 122.1 1.0 OD2 B:ASP128 4.3 107.5 1.0 N B:ALA125 4.3 99.0 1.0 CB B:HIS126 4.3 105.7 1.0 N B:HIS126 4.3 105.7 1.0 OG1 B:THR246 4.3 119.1 1.0 CG B:HIS126 4.4 105.7 1.0 CA B:ASP124 4.5 118.1 1.0 CE1 B:HIS126 4.5 105.7 1.0 CG B:GLU277 4.7 127.9 1.0 OD1 B:ASP128 4.7 107.5 1.0 CG B:HIS101 4.8 123.9 1.0 C B:ASP124 4.9 118.1 1.0 CB B:ASP234 4.9 117.5 1.0 CG B:ASP128 4.9 107.5 1.0 CA B:HIS126 4.9 105.7 1.0 CD2 B:HIS101 4.9 123.9 1.0

Manganese binding site 5 out of 12 in the Trimeric Human Arginase 1 in Complex with MAB4


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 5 of Trimeric Human Arginase 1 in Complex with MAB4 within 5.0Å range: probe atom residue distance (Å) B Occ C:Mn1001 b:149.2 occ:1.00 MN C:MN1002 0.9 142.6 1.0 OD1 C:ASP124 2.0 112.8 1.0 OD2 C:ASP232 2.1 129.5 1.0 CE1 C:HIS101 2.1 123.3 1.0 OD2 C:ASP124 2.1 112.8 1.0 CG C:ASP124 2.1 112.8 1.0 ND1 C:HIS101 2.8 123.3 1.0 CG C:ASP232 3.1 129.5 1.0 NE2 C:HIS101 3.1 123.3 1.0 CB C:ASP124 3.5 112.8 1.0 CB C:ASP232 3.5 129.5 1.0 OD2 C:ASP128 3.5 109.7 1.0 OD1 C:ASP234 3.6 122.2 1.0 OD2 C:ASP234 3.9 122.2 1.0 CG C:HIS101 4.1 123.3 1.0 CG C:ASP234 4.1 122.2 1.0 OD1 C:ASP232 4.2 129.5 1.0 ND1 C:HIS126 4.2 116.8 1.0 CD2 C:HIS101 4.2 123.3 1.0 CG C:ASP128 4.3 109.7 1.0 OD1 C:ASP128 4.3 109.7 1.0 CA C:ASP124 4.3 112.8 1.0 CB C:HIS126 4.5 116.8 1.0 N C:HIS126 4.5 116.8 1.0 N C:ALA125 4.5 104.6 1.0 CG C:GLU277 4.6 130.6 1.0 CG C:HIS126 4.8 116.8 1.0 C C:ASP124 4.9 112.8 1.0 O C:HIS126 4.9 116.8 1.0 CA C:ASP232 4.9 129.5 1.0 NE1 C:TRP122 5.0 122.8 1.0

Manganese binding site 6 out of 12 in the Trimeric Human Arginase 1 in Complex with MAB4


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 6 of Trimeric Human Arginase 1 in Complex with MAB4 within 5.0Å range: probe atom residue distance (Å) B Occ C:Mn1002 b:142.6 occ:1.00 MN C:MN1001 0.9 149.2 1.0 OD2 C:ASP232 1.8 129.5 1.0 OD1 C:ASP124 1.9 112.8 1.0 CG C:ASP124 2.5 112.8 1.0 OD2 C:ASP124 2.6 112.8 1.0 CE1 C:HIS101 2.8 123.3 1.0 CG C:ASP232 3.0 129.5 1.0 OD1 C:ASP234 3.0 122.2 1.0 OD2 C:ASP234 3.0 122.2 1.0 CG C:ASP234 3.4 122.2 1.0 ND1 C:HIS101 3.6 123.3 1.0 ND1 C:HIS126 3.6 116.8 1.0 CB C:ASP232 3.7 129.5 1.0 NE2 C:HIS101 3.8 123.3 1.0 CB C:ASP124 3.9 112.8 1.0 OD1 C:ASP232 4.0 129.5 1.0 OD2 C:ASP128 4.2 109.7 1.0 N C:ALA125 4.3 104.6 1.0 N C:HIS126 4.3 116.8 1.0 CB C:HIS126 4.4 116.8 1.0 OG1 C:THR246 4.4 125.8 1.0 CG C:HIS126 4.4 116.8 1.0 CA C:ASP124 4.5 112.8 1.0 CE1 C:HIS126 4.6 116.8 1.0 CG C:GLU277 4.6 130.6 1.0 OD1 C:ASP128 4.7 109.7 1.0 CG C:HIS101 4.8 123.3 1.0 CB C:ASP234 4.8 122.2 1.0 CG C:ASP128 4.9 109.7 1.0 CD2 C:HIS101 4.9 123.3 1.0 C C:ASP124 4.9 112.8 1.0 CA C:HIS126 4.9 116.8 1.0

Manganese binding site 7 out of 12 in the Trimeric Human Arginase 1 in Complex with MAB4


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 7 of Trimeric Human Arginase 1 in Complex with MAB4 within 5.0Å range: probe atom residue distance (Å) B Occ J:Mn1001 b:680.8 occ:1.00 OD2 J:ASP124 1.9 633.5 1.0 CE1 J:HIS101 2.2 627.9 1.0 MN J:MN1002 2.3 654.0 1.0 OD2 J:ASP128 2.4 677.4 1.0 ND1 J:HIS101 2.5 627.9 1.0 CG J:ASP124 2.6 633.5 1.0 OD1 J:ASP124 2.8 633.5 1.0 CG J:ASP128 3.3 677.4 1.0 OD2 J:ASP232 3.3 593.8 1.0 NE2 J:HIS101 3.4 627.9 1.0 OD1 J:ASP128 3.5 677.4 1.0 CB J:HIS126 3.8 666.4 1.0 CG J:HIS101 3.8 627.9 1.0 CB J:ASP124 4.0 633.5 1.0 ND1 J:HIS126 4.2 666.4 1.0 CD2 J:HIS101 4.3 627.9 1.0 CG J:ASP232 4.3 593.8 1.0 CG J:HIS126 4.4 666.4 1.0 CZ2 J:TRP122 4.4 613.4 1.0 N J:HIS126 4.6 666.4 1.0 O J:HIS126 4.6 666.4 1.0 CB J:ASP128 4.6 677.4 1.0 CA J:HIS126 4.7 666.4 1.0 CB J:ASP232 4.7 593.8 1.0 OD1 J:ASP234 4.7 611.1 1.0 O J:HIS141 4.7 599.4 1.0 NE1 J:TRP122 4.7 613.4 1.0 C J:HIS126 4.9 666.4 1.0 CB J:HIS101 4.9 627.9 1.0 CE2 J:TRP122 4.9 613.4 1.0 OD2 J:ASP234 4.9 611.1 1.0

Manganese binding site 8 out of 12 in the Trimeric Human Arginase 1 in Complex with MAB4


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 8 of Trimeric Human Arginase 1 in Complex with MAB4 within 5.0Å range: probe atom residue distance (Å) B Occ J:Mn1002 b:654.0 occ:1.00 OD1 J:ASP124 1.9 633.5 1.0 OD2 J:ASP232 2.0 593.8 1.0 MN J:MN1001 2.3 680.8 1.0 OD1 J:ASP234 2.5 611.1 1.0 CG J:ASP124 2.7 633.5 1.0 OD2 J:ASP234 2.8 611.1 1.0 CG J:ASP234 3.0 611.1 1.0 OD2 J:ASP124 3.0 633.5 1.0 CG J:ASP232 3.1 593.8 1.0 CE1 J:HIS101 3.4 627.9 1.0 ND1 J:HIS126 3.5 666.4 1.0 CB J:ASP232 3.8 593.8 1.0 OG1 J:THR246 4.0 609.9 1.0 OD1 J:ASP232 4.1 593.8 1.0 CB J:ASP124 4.1 633.5 1.0 N J:ALA125 4.2 639.2 1.0 NE2 J:HIS101 4.2 627.9 1.0 ND1 J:HIS101 4.3 627.9 1.0 N J:HIS126 4.3 666.4 1.0 CG J:HIS126 4.4 666.4 1.0 CB J:HIS126 4.4 666.4 1.0 CE1 J:HIS126 4.5 666.4 1.0 CB J:ASP234 4.5 611.1 1.0 CA J:ASP124 4.6 633.5 1.0 OD2 J:ASP128 4.7 677.4 1.0 CB J:ALA125 4.8 639.2 1.0 CG J:GLU277 4.8 588.2 1.0 C J:ASP124 4.9 633.5 1.0 CA J:ALA125 4.9 639.2 1.0 CA J:HIS126 5.0 666.4 1.0

Manganese binding site 9 out of 12 in the Trimeric Human Arginase 1 in Complex with MAB4


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 9 of Trimeric Human Arginase 1 in Complex with MAB4 within 5.0Å range: probe atom residue distance (Å) B Occ Q:Mn1001 b:700.1 occ:1.00 OD2 Q:ASP124 1.9 624.4 1.0 CE1 Q:HIS101 2.2 684.9 1.0 MN Q:MN1002 2.3 650.2 1.0 OD2 Q:ASP128 2.5 691.8 1.0 ND1 Q:HIS101 2.6 684.9 1.0 CG Q:ASP124 2.6 624.4 1.0 OD1 Q:ASP124 2.7 624.4 1.0 OD2 Q:ASP232 3.2 617.7 1.0 CG Q:ASP128 3.4 691.8 1.0 NE2 Q:HIS101 3.4 684.9 1.0 OD1 Q:ASP128 3.5 691.8 1.0 CB Q:HIS126 3.8 641.1 1.0 CG Q:HIS101 3.9 684.9 1.0 CB Q:ASP124 4.0 624.4 1.0 ND1 Q:HIS126 4.1 641.1 1.0 CG Q:ASP232 4.3 617.7 1.0 CD2 Q:HIS101 4.3 684.9 1.0 CG Q:HIS126 4.3 641.1 1.0 CZ2 Q:TRP122 4.5 636.8 1.0 N Q:HIS126 4.5 641.1 1.0 OD1 Q:ASP234 4.6 589.8 1.0 O Q:HIS126 4.6 641.1 1.0 CA Q:HIS126 4.6 641.1 1.0 CB Q:ASP232 4.6 617.7 1.0 CB Q:ASP128 4.7 691.8 1.0 NE1 Q:TRP122 4.8 636.8 1.0 O Q:HIS141 4.8 635.1 1.0 OD2 Q:ASP234 4.8 589.8 1.0 C Q:HIS126 4.9 641.1 1.0 CE2 Q:TRP122 5.0 636.8 1.0

Manganese binding site 10 out of 12 in the Trimeric Human Arginase 1 in Complex with MAB4


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 10 of Trimeric Human Arginase 1 in Complex with MAB4 within 5.0Å range: probe atom residue distance (Å) B Occ Q:Mn1002 b:650.2 occ:1.00 OD1 Q:ASP124 1.9 624.4 1.0 OD2 Q:ASP232 2.0 617.7 1.0 MN Q:MN1001 2.3 700.1 1.0 OD1 Q:ASP234 2.4 589.8 1.0 OD2 Q:ASP234 2.7 589.8 1.0 CG Q:ASP124 2.8 624.4 1.0 CG Q:ASP234 2.9 589.8 1.0 OD2 Q:ASP124 3.1 624.4 1.0 CG Q:ASP232 3.2 617.7 1.0 CE1 Q:HIS101 3.4 684.9 1.0 ND1 Q:HIS126 3.5 641.1 1.0 CB Q:ASP232 3.9 617.7 1.0 OG1 Q:THR246 4.0 572.8 1.0 N Q:ALA125 4.1 610.0 1.0 OD1 Q:ASP232 4.1 617.7 1.0 CB Q:ASP124 4.1 624.4 1.0 NE2 Q:HIS101 4.2 684.9 1.0 N Q:HIS126 4.3 641.1 1.0 ND1 Q:HIS101 4.3 684.9 1.0 CG Q:HIS126 4.4 641.1 1.0 CE1 Q:HIS126 4.4 641.1 1.0 CB Q:HIS126 4.4 641.1 1.0 CB Q:ASP234 4.4 589.8 1.0 CA Q:ASP124 4.6 624.4 1.0 CB Q:ALA125 4.7 610.0 1.0 OD2 Q:ASP128 4.8 691.8 1.0 C Q:ASP124 4.8 624.4 1.0 CG Q:GLU277 4.8 634.1 1.0 CA Q:ALA125 4.8 610.0 1.0 CA Q:HIS126 5.0 641.1 1.0

R.L.Palte, V.Juan, Y.Gomez-Llorente, M.A.Bailly, K.Chakravarthy, X.Chen, D.Cipriano, L.Fayadat-Dilman, S.Gathiaka, H.Greb, B.Hall, M.Handa, M.Hsieh, E.Kofman, H.Lin, J.R.Miller, N.Nguyen, J.O'neil, H.Shaheen, E.Sterner, C.Strickland, A.Sun, S.Taremi, G.Scapin. Cryo-Em Structures of Inhibitory Antibodies Complexed with Arginase 1 Provide Insight Into Mechanism of Action. Commun Biol V. 4 927 2021.
ISSN: ESSN 2399-3642
PubMed: 34326456
DOI: 10.1038/S42003-021-02444-Z