Manganese in PDB 7ley: Trimeric Human Arginase 1 in Complex with MAB5

All present enzymatic activity of Trimeric Human Arginase 1 in Complex with MAB5:
3.5.3.1;

The binding sites of Manganese atom in the Trimeric Human Arginase 1 in Complex with MAB5 (pdb code 7ley). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total 6 binding sites of Manganese where determined in the Trimeric Human Arginase 1 in Complex with MAB5, PDB code: 7ley:
Jump to Manganese binding site number: 1; 2; 3; 4; 5; 6;

Manganese binding site 1 out of 6 in the Trimeric Human Arginase 1 in Complex with MAB5


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of Trimeric Human Arginase 1 in Complex with MAB5 within 5.0Å range: probe atom residue distance (Å) B Occ A:Mn1001 b:56.9 occ:1.00 OD2 A:ASP124 1.7 40.9 1.0 OD2 A:ASP128 2.0 36.8 1.0 ND1 A:HIS101 2.1 34.0 1.0 MN A:MN1002 2.2 52.0 1.0 OD2 A:ASP232 2.3 39.5 1.0 CE1 A:HIS101 2.5 34.0 1.0 CG A:ASP124 2.8 40.9 1.0 CG A:ASP128 3.0 36.8 1.0 CG A:HIS101 3.2 34.0 1.0 OD1 A:ASP124 3.4 40.9 1.0 CG A:ASP232 3.4 39.5 1.0 OD1 A:ASP128 3.6 36.8 1.0 NE2 A:HIS101 3.6 34.0 1.0 CB A:ASP124 3.9 40.9 1.0 CD2 A:HIS101 3.9 34.0 1.0 CB A:HIS101 4.0 34.0 1.0 CB A:ASP232 4.1 39.5 1.0 CB A:ASP128 4.2 36.8 1.0 OD1 A:ASP232 4.4 39.5 1.0 NE1 A:TRP122 4.4 54.4 1.0 OD2 A:ASP234 4.4 34.3 1.0 O A:HIS141 4.6 35.9 1.0 CG A:GLU277 4.7 36.1 1.0 OD1 A:ASP234 4.7 34.3 1.0 OE2 A:GLU277 4.7 36.1 1.0 CD2 A:HIS126 4.8 36.4 1.0 CB A:HIS126 4.8 36.4 1.0 CD A:GLU277 4.9 36.1 1.0 CZ2 A:TRP122 4.9 54.4 1.0 CG A:ASP234 5.0 34.3 1.0

Manganese binding site 2 out of 6 in the Trimeric Human Arginase 1 in Complex with MAB5


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 2 of Trimeric Human Arginase 1 in Complex with MAB5 within 5.0Å range: probe atom residue distance (Å) B Occ A:Mn1002 b:52.0 occ:1.00 OD1 A:ASP124 1.8 40.9 1.0 OD2 A:ASP232 1.9 39.5 1.0 OD2 A:ASP124 2.0 40.9 1.0 CG A:ASP124 2.1 40.9 1.0 MN A:MN1001 2.2 56.9 1.0 OD2 A:ASP234 2.4 34.3 1.0 OD1 A:ASP234 2.8 34.3 1.0 CG A:ASP232 3.0 39.5 1.0 CG A:ASP234 3.0 34.3 1.0 CD2 A:HIS126 3.1 36.4 1.0 CB A:ASP124 3.6 40.9 1.0 OD1 A:ASP232 3.8 39.5 1.0 OD2 A:ASP128 3.8 36.8 1.0 CB A:ASP232 3.9 39.5 1.0 CG A:HIS126 3.9 36.4 1.0 CE1 A:HIS101 4.0 34.0 1.0 CB A:HIS126 4.0 36.4 1.0 ND1 A:HIS101 4.1 34.0 1.0 N A:HIS126 4.2 36.4 1.0 NE2 A:HIS126 4.3 36.4 1.0 N A:ALA125 4.3 35.6 1.0 CA A:ASP124 4.3 40.9 1.0 CB A:ASP234 4.5 34.3 1.0 CG A:ASP128 4.5 36.8 1.0 OD1 A:ASP128 4.6 36.8 1.0 C A:ASP124 4.7 40.9 1.0 CA A:HIS126 4.7 36.4 1.0 CG A:GLU277 4.9 36.1 1.0

Manganese binding site 3 out of 6 in the Trimeric Human Arginase 1 in Complex with MAB5


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 3 of Trimeric Human Arginase 1 in Complex with MAB5 within 5.0Å range: probe atom residue distance (Å) B Occ B:Mn1001 b:58.9 occ:1.00 OD2 B:ASP124 1.7 41.6 1.0 OD2 B:ASP128 2.0 37.3 1.0 ND1 B:HIS101 2.1 36.1 1.0 MN B:MN1002 2.2 53.5 1.0 OD2 B:ASP232 2.3 39.7 1.0 CE1 B:HIS101 2.5 36.1 1.0 CG B:ASP124 2.8 41.6 1.0 CG B:ASP128 3.0 37.3 1.0 CG B:HIS101 3.2 36.1 1.0 OD1 B:ASP124 3.4 41.6 1.0 CG B:ASP232 3.4 39.7 1.0 OD1 B:ASP128 3.6 37.3 1.0 NE2 B:HIS101 3.6 36.1 1.0 CB B:ASP124 3.9 41.6 1.0 CD2 B:HIS101 3.9 36.1 1.0 CB B:HIS101 4.0 36.1 1.0 CB B:ASP232 4.1 39.7 1.0 CB B:ASP128 4.2 37.3 1.0 OD1 B:ASP232 4.4 39.7 1.0 NE1 B:TRP122 4.4 54.4 1.0 OD2 B:ASP234 4.4 34.6 1.0 O B:HIS141 4.6 37.1 1.0 CG B:GLU277 4.7 36.4 1.0 OD1 B:ASP234 4.7 34.6 1.0 OE2 B:GLU277 4.7 36.4 1.0 CD2 B:HIS126 4.8 36.4 1.0 CB B:HIS126 4.8 36.4 1.0 CD B:GLU277 4.9 36.4 1.0 CZ2 B:TRP122 4.9 54.4 1.0 CG B:ASP234 5.0 34.6 1.0

Manganese binding site 4 out of 6 in the Trimeric Human Arginase 1 in Complex with MAB5


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 4 of Trimeric Human Arginase 1 in Complex with MAB5 within 5.0Å range: probe atom residue distance (Å) B Occ B:Mn1002 b:53.5 occ:1.00 OD1 B:ASP124 1.8 41.6 1.0 OD2 B:ASP232 1.9 39.7 1.0 OD2 B:ASP124 2.0 41.6 1.0 CG B:ASP124 2.1 41.6 1.0 MN B:MN1001 2.2 58.9 1.0 OD2 B:ASP234 2.4 34.6 1.0 OD1 B:ASP234 2.8 34.6 1.0 CG B:ASP232 3.0 39.7 1.0 CG B:ASP234 3.0 34.6 1.0 CD2 B:HIS126 3.1 36.4 1.0 CB B:ASP124 3.6 41.6 1.0 OD1 B:ASP232 3.8 39.7 1.0 OD2 B:ASP128 3.8 37.3 1.0 CB B:ASP232 3.9 39.7 1.0 CG B:HIS126 3.9 36.4 1.0 CE1 B:HIS101 4.0 36.1 1.0 CB B:HIS126 4.0 36.4 1.0 ND1 B:HIS101 4.1 36.1 1.0 N B:HIS126 4.2 36.4 1.0 NE2 B:HIS126 4.3 36.4 1.0 N B:ALA125 4.3 35.7 1.0 CA B:ASP124 4.3 41.6 1.0 CB B:ASP234 4.5 34.6 1.0 CG B:ASP128 4.5 37.3 1.0 OD1 B:ASP128 4.6 37.3 1.0 C B:ASP124 4.7 41.6 1.0 CA B:HIS126 4.7 36.4 1.0 CG B:GLU277 4.9 36.4 1.0

Manganese binding site 5 out of 6 in the Trimeric Human Arginase 1 in Complex with MAB5


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 5 of Trimeric Human Arginase 1 in Complex with MAB5 within 5.0Å range: probe atom residue distance (Å) B Occ C:Mn1001 b:57.5 occ:1.00 OD2 C:ASP124 1.7 41.8 1.0 OD2 C:ASP128 2.0 37.8 1.0 ND1 C:HIS101 2.1 35.4 1.0 MN C:MN1002 2.2 55.0 1.0 OD2 C:ASP232 2.3 38.0 1.0 CE1 C:HIS101 2.5 35.4 1.0 CG C:ASP124 2.8 41.8 1.0 CG C:ASP128 3.0 37.8 1.0 CG C:HIS101 3.2 35.4 1.0 OD1 C:ASP124 3.4 41.8 1.0 CG C:ASP232 3.4 38.0 1.0 OD1 C:ASP128 3.6 37.8 1.0 NE2 C:HIS101 3.6 35.4 1.0 CB C:ASP124 3.9 41.8 1.0 CD2 C:HIS101 3.9 35.4 1.0 CB C:HIS101 4.0 35.4 1.0 CB C:ASP232 4.1 38.0 1.0 CB C:ASP128 4.2 37.8 1.0 OD1 C:ASP232 4.4 38.0 1.0 NE1 C:TRP122 4.4 54.4 1.0 OD2 C:ASP234 4.4 35.5 1.0 O C:HIS141 4.6 37.4 1.0 CG C:GLU277 4.7 37.2 1.0 OD1 C:ASP234 4.7 35.5 1.0 OE2 C:GLU277 4.7 37.2 1.0 CD2 C:HIS126 4.8 37.7 1.0 CB C:HIS126 4.8 37.7 1.0 CD C:GLU277 4.9 37.2 1.0 CZ2 C:TRP122 4.9 54.4 1.0 CG C:ASP234 5.0 35.5 1.0

Manganese binding site 6 out of 6 in the Trimeric Human Arginase 1 in Complex with MAB5


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 6 of Trimeric Human Arginase 1 in Complex with MAB5 within 5.0Å range: probe atom residue distance (Å) B Occ C:Mn1002 b:55.0 occ:1.00 OD1 C:ASP124 1.8 41.8 1.0 OD2 C:ASP232 1.9 38.0 1.0 OD2 C:ASP124 2.0 41.8 1.0 CG C:ASP124 2.1 41.8 1.0 MN C:MN1001 2.2 57.5 1.0 OD2 C:ASP234 2.4 35.5 1.0 OD1 C:ASP234 2.8 35.5 1.0 CG C:ASP232 3.0 38.0 1.0 CG C:ASP234 3.0 35.5 1.0 CD2 C:HIS126 3.1 37.7 1.0 CB C:ASP124 3.6 41.8 1.0 OD1 C:ASP232 3.8 38.0 1.0 OD2 C:ASP128 3.8 37.8 1.0 CB C:ASP232 3.9 38.0 1.0 CG C:HIS126 3.9 37.7 1.0 CE1 C:HIS101 4.0 35.4 1.0 CB C:HIS126 4.0 37.7 1.0 ND1 C:HIS101 4.1 35.4 1.0 N C:HIS126 4.2 37.7 1.0 NE2 C:HIS126 4.3 37.7 1.0 N C:ALA125 4.3 36.7 1.0 CA C:ASP124 4.3 41.8 1.0 CB C:ASP234 4.5 35.5 1.0 CG C:ASP128 4.5 37.8 1.0 OD1 C:ASP128 4.6 37.8 1.0 C C:ASP124 4.7 41.8 1.0 CA C:HIS126 4.7 37.7 1.0 CG C:GLU277 4.9 37.2 1.0

R.L.Palte, V.Juan, Y.Gomez-Llorente, M.A.Bailly, K.Chakravarthy, X.Chen, D.Cipriano, L.Fayadat-Dilman, S.Gathiaka, H.Greb, B.Hall, M.Handa, M.Hsieh, E.Kofman, H.Lin, J.R.Miller, N.Nguyen, J.O'neil, H.Shaheen, E.Sterner, C.Strickland, A.Sun, S.Taremi, G.Scapin. Cryo-Em Structures of Inhibitory Antibodies Complexed with Arginase 1 Provide Insight Into Mechanism of Action. Commun Biol V. 4 927 2021.
ISSN: ESSN 2399-3642
PubMed: 34326456
DOI: 10.1038/S42003-021-02444-Z