Manganese in PDB 6hzn: Crystal Structure of Human Dermatan Sulfate Epimerase 1

All present enzymatic activity of Crystal Structure of Human Dermatan Sulfate Epimerase 1:
5.1.3.19;

The structure of Crystal Structure of Human Dermatan Sulfate Epimerase 1, PDB code: 6hzn was solved by M.Hasan, J.Unge, G.Westergren-Thorsson, U.Ellervik, U.Mueller, A.Malmstrom, E.Tykesson, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	48.57 / 2.41
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	182.676, 213.914, 86.945, 90.00, 90.00, 90.00
R / Rfree (%)	17.6 / 20.9

The binding sites of Manganese atom in the Crystal Structure of Human Dermatan Sulfate Epimerase 1 (pdb code 6hzn). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total only one binding site of Manganese was determined in the Crystal Structure of Human Dermatan Sulfate Epimerase 1, PDB code: 6hzn:

Manganese binding site 1 out of 1 in the Crystal Structure of Human Dermatan Sulfate Epimerase 1


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of Crystal Structure of Human Dermatan Sulfate Epimerase 1 within 5.0Å range: probe atom residue distance (Å) B Occ A:Mn810 b:72.3 occ:1.00 OD1 A:ASN481 2.2 90.6 1.0 OE1 A:GLU470 2.2 77.4 1.0 O A:HOH907 2.2 64.0 1.0 O A:HOH904 2.2 71.0 1.0 O A:HOH902 2.2 71.0 1.0 ND1 A:HIS452 2.4 67.2 1.0 CD A:GLU470 3.1 71.7 1.0 CE1 A:HIS452 3.2 69.1 1.0 CG A:ASN481 3.3 76.1 1.0 CG A:HIS452 3.4 68.5 1.0 OE2 A:GLU470 3.4 72.5 1.0 O A:ALA471 3.5 0.1 1.0 CB A:HIS452 3.8 68.7 1.0 ND2 A:ASN481 4.1 80.0 1.0 N A:ALA312 4.2 75.7 1.0 NE2 A:HIS452 4.4 67.8 1.0 CB A:ASN481 4.4 74.7 1.0 O A:HOH997 4.4 68.4 1.0 CG A:GLU470 4.4 71.5 1.0 O A:PHE480 4.5 79.9 1.0 OD2 A:ASP454 4.5 68.9 1.0 CD2 A:HIS452 4.5 68.7 1.0 O A:ALA312 4.5 75.0 1.0 CB A:ASP454 4.6 60.2 1.0 CA A:ALA312 4.7 74.4 1.0 C A:ALA471 4.7 98.3 1.0 CB A:GLU470 4.7 73.8 1.0 N A:ALA471 4.8 76.0 1.0 CA A:ASN481 4.8 75.0 1.0 O A:ALA310 4.8 64.3 1.0 C A:ALA312 4.9 72.0 1.0 O A:LEU472 4.9 88.1 1.0

M.Hasan, H.Khakzad, L.Happonen, J.Unge, U.Mueller, J.Malmstrom, G.Westergren-Thorsson, U.Ellervik, L.Malmstrom, A.Malmstrom, E.Tykesson. The Structure of Human Dermatan Sulfate Epimerase 1 Reveals A Novel Eukaryotic Protein Domain Fold. Under Review. To Be Published 2020.