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Atomistry » Manganese » PDB 6a9v-6bh4 » 6bgx | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Manganese » PDB 6a9v-6bh4 » 6bgx » |
Manganese in PDB 6bgx: Linked KDM5A Jmj Domain Bound to the Inhibitor 2-((2-Chlorophenyl)((4, 4-Difluorocyclohexyl)Methoxy)Methyl)-1H-Pyrrolo[3,2-B]Pyridine-7- Carboxylic Acid(Compound N42)Protein crystallography data
The structure of Linked KDM5A Jmj Domain Bound to the Inhibitor 2-((2-Chlorophenyl)((4, 4-Difluorocyclohexyl)Methoxy)Methyl)-1H-Pyrrolo[3,2-B]Pyridine-7- Carboxylic Acid(Compound N42), PDB code: 6bgx
was solved by
J.R.Horton,
X.Cheng,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 6bgx:
The structure of Linked KDM5A Jmj Domain Bound to the Inhibitor 2-((2-Chlorophenyl)((4, 4-Difluorocyclohexyl)Methoxy)Methyl)-1H-Pyrrolo[3,2-B]Pyridine-7- Carboxylic Acid(Compound N42) also contains other interesting chemical elements:
Manganese Binding Sites:
The binding sites of Manganese atom in the Linked KDM5A Jmj Domain Bound to the Inhibitor 2-((2-Chlorophenyl)((4, 4-Difluorocyclohexyl)Methoxy)Methyl)-1H-Pyrrolo[3,2-B]Pyridine-7- Carboxylic Acid(Compound N42)
(pdb code 6bgx). This binding sites where shown within
5.0 Angstroms radius around Manganese atom.
In total only one binding site of Manganese was determined in the Linked KDM5A Jmj Domain Bound to the Inhibitor 2-((2-Chlorophenyl)((4, 4-Difluorocyclohexyl)Methoxy)Methyl)-1H-Pyrrolo[3,2-B]Pyridine-7- Carboxylic Acid(Compound N42), PDB code: 6bgx: Manganese binding site 1 out of 1 in 6bgxGo back to![]() ![]()
Manganese binding site 1 out
of 1 in the Linked KDM5A Jmj Domain Bound to the Inhibitor 2-((2-Chlorophenyl)((4, 4-Difluorocyclohexyl)Methoxy)Methyl)-1H-Pyrrolo[3,2-B]Pyridine-7- Carboxylic Acid(Compound N42)
![]() Mono view ![]() Stereo pair view
Reference:
J.R.Horton,
X.Liu,
L.Wu,
K.Zhang,
J.Shanks,
X.Zhang,
G.Rai,
B.T.Mott,
D.J.Jansen,
S.C.Kales,
M.J.Henderson,
K.Pohida,
Y.Fang,
X.Hu,
A.Jadhav,
D.J.Maloney,
M.D.Hall,
A.Simeonov,
H.Fu,
P.M.Vertino,
Q.Yan,
X.Cheng.
Insights Into the Action of Inhibitor Enantiomers Against Histone Lysine Demethylase 5A. J. Med. Chem. V. 61 3193 2018.
Page generated: Sun Oct 6 03:55:23 2024
ISSN: ISSN 1520-4804 PubMed: 29537847 DOI: 10.1021/ACS.JMEDCHEM.8B00261 |
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