|
Atomistry » Manganese » PDB 5nha-5raa » 5ox6 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Manganese » PDB 5nha-5raa » 5ox6 » |
Manganese in PDB 5ox6: Hif Prolyl Hydroxylase 2 (PHD2/ EGLN1) in Complex with VadadustatEnzymatic activity of Hif Prolyl Hydroxylase 2 (PHD2/ EGLN1) in Complex with Vadadustat
All present enzymatic activity of Hif Prolyl Hydroxylase 2 (PHD2/ EGLN1) in Complex with Vadadustat:
1.14.11.29; Protein crystallography data
The structure of Hif Prolyl Hydroxylase 2 (PHD2/ EGLN1) in Complex with Vadadustat, PDB code: 5ox6
was solved by
R.Chowdhury,
D.Zhang,
C.J.Schofield,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 5ox6:
The structure of Hif Prolyl Hydroxylase 2 (PHD2/ EGLN1) in Complex with Vadadustat also contains other interesting chemical elements:
Manganese Binding Sites:
The binding sites of Manganese atom in the Hif Prolyl Hydroxylase 2 (PHD2/ EGLN1) in Complex with Vadadustat
(pdb code 5ox6). This binding sites where shown within
5.0 Angstroms radius around Manganese atom.
In total only one binding site of Manganese was determined in the Hif Prolyl Hydroxylase 2 (PHD2/ EGLN1) in Complex with Vadadustat, PDB code: 5ox6: Manganese binding site 1 out of 1 in 5ox6Go back to![]() ![]()
Manganese binding site 1 out
of 1 in the Hif Prolyl Hydroxylase 2 (PHD2/ EGLN1) in Complex with Vadadustat
![]() Mono view ![]() Stereo pair view
Reference:
T.L.Yeh,
T.M.Leissing,
M.I.Abboud,
C.C.Thinnes,
O.Atasoylu,
J.P.Holt-Martyn,
D.Zhang,
A.Tumber,
K.Lippl,
C.T.Lohans,
I.K.H.Leung,
H.Morcrette,
I.J.Clifton,
T.D.W.Claridge,
A.Kawamura,
E.Flashman,
X.Lu,
P.J.Ratcliffe,
R.Chowdhury,
C.W.Pugh,
C.J.Schofield.
Molecular and Cellular Mechanisms of Hif Prolyl Hydroxylase Inhibitors in Clinical Trials. Chem Sci V. 8 7651 2017.
Page generated: Sun Oct 6 02:25:39 2024
ISSN: ISSN 2041-6520 PubMed: 29435217 DOI: 10.1039/C7SC02103H |
Last articlesFe in 2YXOFe in 2YRS Fe in 2YXC Fe in 2YNM Fe in 2YVJ Fe in 2YP1 Fe in 2YU2 Fe in 2YU1 Fe in 2YQB Fe in 2YOO |
© Copyright 2008-2020 by atomistry.com | ||
Home | Site Map | Copyright | Contact us | Privacy |