Manganese in PDB 5n62: Human Ttr Crystals Soaked in Manganese Chloride.

The structure of Human Ttr Crystals Soaked in Manganese Chloride., PDB code: 5n62 was solved by L.Ciccone, M.Savko, W.Shepard, E.A.Stura, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	38.64 / 1.80
Space group	P 21 21 2
Cell size a, b, c (Å), α, β, γ (°)	43.270, 85.830, 63.900, 90.00, 90.00, 90.00
R / Rfree (%)	19.5 / 24.5

The binding sites of Manganese atom in the Human Ttr Crystals Soaked in Manganese Chloride. (pdb code 5n62). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total 2 binding sites of Manganese where determined in the Human Ttr Crystals Soaked in Manganese Chloride., PDB code: 5n62:
Jump to Manganese binding site number: 1; 2;

Manganese binding site 1 out of 2 in the Human Ttr Crystals Soaked in Manganese Chloride.


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of Human Ttr Crystals Soaked in Manganese Chloride. within 5.0Å range: probe atom residue distance (Å) B Occ A:Mn201 b:87.5 occ:1.00 OE2 A:GLU66 2.1 83.9 1.0 OD1 A:ASP99 2.2 48.3 1.0 O A:HOH416 2.2 61.6 1.0 O A:HOH320 2.2 59.1 1.0 O A:HOH339 2.2 47.3 1.0 O A:ASP99 2.4 34.6 1.0 CG A:ASP99 3.2 48.0 1.0 CD A:GLU66 3.3 43.2 1.0 C A:ASP99 3.3 41.8 1.0 CA A:ASP99 3.6 31.7 1.0 OE1 A:GLU66 3.8 33.8 1.0 CB A:ASP99 4.0 36.4 1.0 OD2 A:ASP99 4.1 60.7 1.0 O A:HOH312 4.2 52.4 1.0 CG A:GLU66 4.5 39.5 1.0 N A:SER100 4.6 38.5 1.0 O A:ASN98 4.9 29.2 1.0 N A:ASP99 4.9 22.4 1.0 O A:HOH414 4.9 46.2 1.0

Manganese binding site 2 out of 2 in the Human Ttr Crystals Soaked in Manganese Chloride.


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 2 of Human Ttr Crystals Soaked in Manganese Chloride. within 5.0Å range: probe atom residue distance (Å) B Occ B:Mn201 b:87.0 occ:1.00 O B:HOH323 2.2 0.9 1.0 O B:HOH328 2.3 48.8 1.0 OD1 B:ASN98 2.3 93.0 1.0 OE2 B:GLU66 2.3 56.1 1.0 CD B:GLU66 3.3 44.3 1.0 CG B:ASN98 3.6 62.0 1.0 OE1 B:GLU66 3.6 31.5 1.0 O B:ASP99 4.1 65.4 1.0 O B:HOH390 4.2 44.7 1.0 ND2 B:ASN98 4.3 70.6 1.0 N B:ASP99 4.4 47.4 1.0 CG B:GLU66 4.7 27.5 1.0 CB B:ASN98 4.7 51.5 1.0 CA B:ASN98 4.9 41.8 1.0 O B:HOH379 4.9 57.8 1.0

L.Ciccone, C.Fruchart-Gaillard, G.Mourier, M.Savko, S.Nencetti, E.Orlandini, D.Servent, E.A.Stura, W.Shepard. Copper Mediated Amyloid-Beta Binding to Transthyretin. Sci Rep V. 8 13744 2018.
ISSN: ESSN 2045-2322
PubMed: 30213975
DOI: 10.1038/S41598-018-31808-5