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PDB 4z8b-5a56 »
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Manganese in PDB 4zvz: Co-Crystal Structures of PP5 in Complex with 5-Methyl-7- Oxabicyclo[2.2.1]Heptane-2,3-Dicarboxylic Acid
Enzymatic activity of Co-Crystal Structures of PP5 in Complex with 5-Methyl-7- Oxabicyclo[2.2.1]Heptane-2,3-Dicarboxylic Acid
All present enzymatic activity of Co-Crystal Structures of PP5 in Complex with 5-Methyl-7- Oxabicyclo[2.2.1]Heptane-2,3-Dicarboxylic Acid:
3.1.3.16;
3.1.3.16;
Protein crystallography data
The structure of Co-Crystal Structures of PP5 in Complex with 5-Methyl-7- Oxabicyclo[2.2.1]Heptane-2,3-Dicarboxylic Acid, PDB code: 4zvz
was solved by
D.Chattopadhyay,
M.R.Swingle,
E.A.Salter,
A.Wierzbicki,
R.E.Honkanen,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 91.03 / 2.00 |
| Space group | P 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 40.858, 80.520, 91.165, 88.15, 87.33, 86.71 |
| R / Rfree (%) | 20.4 / 23.5 |
Other elements in 4zvz:
The structure of Co-Crystal Structures of PP5 in Complex with 5-Methyl-7- Oxabicyclo[2.2.1]Heptane-2,3-Dicarboxylic Acid also contains other interesting chemical elements:
| Sodium | (Na) | 1 atom |
Manganese Binding Sites:
The binding sites of Manganese atom in the Co-Crystal Structures of PP5 in Complex with 5-Methyl-7- Oxabicyclo[2.2.1]Heptane-2,3-Dicarboxylic Acid
(pdb code 4zvz). This binding sites where shown within
5.0 Angstroms radius around Manganese atom.
In total 8 binding sites of Manganese where determined in the Co-Crystal Structures of PP5 in Complex with 5-Methyl-7- Oxabicyclo[2.2.1]Heptane-2,3-Dicarboxylic Acid, PDB code: 4zvz:
Jump to Manganese binding site number: 1; 2; 3; 4; 5; 6; 7; 8;
In total 8 binding sites of Manganese where determined in the Co-Crystal Structures of PP5 in Complex with 5-Methyl-7- Oxabicyclo[2.2.1]Heptane-2,3-Dicarboxylic Acid, PDB code: 4zvz:
Jump to Manganese binding site number: 1; 2; 3; 4; 5; 6; 7; 8;
Manganese binding site 1 out of 8 in 4zvz
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Manganese Binding Sites List in 4zvz
Manganese binding site 1 out
of 8 in the Co-Crystal Structures of PP5 in Complex with 5-Methyl-7- Oxabicyclo[2.2.1]Heptane-2,3-Dicarboxylic Acid
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Manganese with other atoms in the Mn binding
site number 1 of Co-Crystal Structures of PP5 in Complex with 5-Methyl-7- Oxabicyclo[2.2.1]Heptane-2,3-Dicarboxylic Acid within 5.0Å range:
|
Manganese binding site 2 out of 8 in 4zvz
Go back to
Manganese Binding Sites List in 4zvz
Manganese binding site 2 out
of 8 in the Co-Crystal Structures of PP5 in Complex with 5-Methyl-7- Oxabicyclo[2.2.1]Heptane-2,3-Dicarboxylic Acid
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Manganese with other atoms in the Mn binding
site number 2 of Co-Crystal Structures of PP5 in Complex with 5-Methyl-7- Oxabicyclo[2.2.1]Heptane-2,3-Dicarboxylic Acid within 5.0Å range:
|
Manganese binding site 3 out of 8 in 4zvz
Go back to
Manganese Binding Sites List in 4zvz
Manganese binding site 3 out
of 8 in the Co-Crystal Structures of PP5 in Complex with 5-Methyl-7- Oxabicyclo[2.2.1]Heptane-2,3-Dicarboxylic Acid
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Manganese with other atoms in the Mn binding
site number 3 of Co-Crystal Structures of PP5 in Complex with 5-Methyl-7- Oxabicyclo[2.2.1]Heptane-2,3-Dicarboxylic Acid within 5.0Å range:
|
Manganese binding site 4 out of 8 in 4zvz
Go back to
Manganese Binding Sites List in 4zvz
Manganese binding site 4 out
of 8 in the Co-Crystal Structures of PP5 in Complex with 5-Methyl-7- Oxabicyclo[2.2.1]Heptane-2,3-Dicarboxylic Acid
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Manganese with other atoms in the Mn binding
site number 4 of Co-Crystal Structures of PP5 in Complex with 5-Methyl-7- Oxabicyclo[2.2.1]Heptane-2,3-Dicarboxylic Acid within 5.0Å range:
|
Manganese binding site 5 out of 8 in 4zvz
Go back to
Manganese Binding Sites List in 4zvz
Manganese binding site 5 out
of 8 in the Co-Crystal Structures of PP5 in Complex with 5-Methyl-7- Oxabicyclo[2.2.1]Heptane-2,3-Dicarboxylic Acid
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Manganese with other atoms in the Mn binding
site number 5 of Co-Crystal Structures of PP5 in Complex with 5-Methyl-7- Oxabicyclo[2.2.1]Heptane-2,3-Dicarboxylic Acid within 5.0Å range:
|
Manganese binding site 6 out of 8 in 4zvz
Go back to
Manganese Binding Sites List in 4zvz
Manganese binding site 6 out
of 8 in the Co-Crystal Structures of PP5 in Complex with 5-Methyl-7- Oxabicyclo[2.2.1]Heptane-2,3-Dicarboxylic Acid
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Manganese with other atoms in the Mn binding
site number 6 of Co-Crystal Structures of PP5 in Complex with 5-Methyl-7- Oxabicyclo[2.2.1]Heptane-2,3-Dicarboxylic Acid within 5.0Å range:
|
Manganese binding site 7 out of 8 in 4zvz
Go back to
Manganese Binding Sites List in 4zvz
Manganese binding site 7 out
of 8 in the Co-Crystal Structures of PP5 in Complex with 5-Methyl-7- Oxabicyclo[2.2.1]Heptane-2,3-Dicarboxylic Acid
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Manganese with other atoms in the Mn binding
site number 7 of Co-Crystal Structures of PP5 in Complex with 5-Methyl-7- Oxabicyclo[2.2.1]Heptane-2,3-Dicarboxylic Acid within 5.0Å range:
|
Manganese binding site 8 out of 8 in 4zvz
Go back to
Manganese Binding Sites List in 4zvz
Manganese binding site 8 out
of 8 in the Co-Crystal Structures of PP5 in Complex with 5-Methyl-7- Oxabicyclo[2.2.1]Heptane-2,3-Dicarboxylic Acid
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Manganese with other atoms in the Mn binding
site number 8 of Co-Crystal Structures of PP5 in Complex with 5-Methyl-7- Oxabicyclo[2.2.1]Heptane-2,3-Dicarboxylic Acid within 5.0Å range:
|
Reference:
D.Chattopadhyay,
M.R.Swingle,
E.A.Salter,
E.Wood,
B.D'arcy,
C.Zivanov,
K.Abney,
A.Musiyenko,
S.F.Rusin,
A.Kettenbach,
L.Yet,
C.E.Schroeder,
J.E.Golden,
W.H.Dunham,
A.C.Gingras,
S.Banerjee,
D.Forbes,
A.Wierzbicki,
R.E.Honkanen.
Crystal Structures and Mutagenesis of Ppp-Family Ser/Thr Protein Phosphatases Elucidate the Selectivity of Cantharidin and Novel Norcantharidin-Based Inhibitors of PP5C. Biochem. Pharmacol. V. 109 14 2016.
ISSN: ISSN 1873-2968
PubMed: 27002182
DOI: 10.1016/J.BCP.2016.03.011
Page generated: Sat Oct 5 23:15:41 2024
ISSN: ISSN 1873-2968
PubMed: 27002182
DOI: 10.1016/J.BCP.2016.03.011
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