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Manganese in PDB 4nii: Crystal Structure of Alkb D135I Mutant Protein with Cofactors Bound to Dsdna Containing M6A/A

Enzymatic activity of Crystal Structure of Alkb D135I Mutant Protein with Cofactors Bound to Dsdna Containing M6A/A

All present enzymatic activity of Crystal Structure of Alkb D135I Mutant Protein with Cofactors Bound to Dsdna Containing M6A/A:
1.14.11.33;

Protein crystallography data

The structure of Crystal Structure of Alkb D135I Mutant Protein with Cofactors Bound to Dsdna Containing M6A/A, PDB code: 4nii was solved by C.Q.Yi, C.X.Zhu, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 37.06 / 1.62
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 41.374, 75.902, 52.285, 90.00, 108.60, 90.00
R / Rfree (%) 17.4 / 20.9

Manganese Binding Sites:

The binding sites of Manganese atom in the Crystal Structure of Alkb D135I Mutant Protein with Cofactors Bound to Dsdna Containing M6A/A (pdb code 4nii). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total only one binding site of Manganese was determined in the Crystal Structure of Alkb D135I Mutant Protein with Cofactors Bound to Dsdna Containing M6A/A, PDB code: 4nii:

Manganese binding site 1 out of 1 in 4nii

Go back to Manganese Binding Sites List in 4nii
Manganese binding site 1 out of 1 in the Crystal Structure of Alkb D135I Mutant Protein with Cofactors Bound to Dsdna Containing M6A/A


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of Crystal Structure of Alkb D135I Mutant Protein with Cofactors Bound to Dsdna Containing M6A/A within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mn301

b:13.4
occ:1.00
 OD1 A:ASP133 2.2 15.1 1.0
O1 A:AKG302 2.2 18.7 1.0
NE2 A:HIS131 2.2 11.9 1.0
NE2 A:HIS187 2.3 12.3 1.0
O A:HOH449 2.4 14.8 1.0
O5 A:AKG302 2.4 17.3 1.0
C1 A:AKG302 3.0 21.3 1.0
CG A:ASP133 3.1 16.4 1.0
C2 A:AKG302 3.1 19.3 1.0
CE1 A:HIS131 3.1 12.1 1.0
CE1 A:HIS187 3.2 12.1 1.0
CD2 A:HIS131 3.2 11.8 1.0
CD2 A:HIS187 3.3 12.4 1.0
OD2 A:ASP133 3.3 17.9 1.0
O A:HOH415 3.8 16.2 1.0
O A:HOH452 4.1 20.9 1.0
O2 A:AKG302 4.3 22.5 1.0
ND1 A:HIS131 4.3 12.0 1.0
ND1 A:HIS187 4.3 12.7 1.0
N1 B:6MA8 4.3 13.8 1.0
CG A:HIS131 4.3 11.8 1.0
CG A:HIS187 4.4 11.7 1.0
CB A:ASP133 4.4 15.9 1.0
C2 B:6MA8 4.4 13.6 1.0
C3 A:AKG302 4.6 16.8 1.0
C6 B:6MA8 4.7 13.7 1.0
CZ2 A:TRP178 4.7 13.6 1.0
N A:ASP133 4.9 15.3 1.0
CA A:ASP133 4.9 16.8 1.0
N3 B:6MA8 5.0 12.7 1.0

Reference:

C.Zhu, C.Yi. Switching Demethylation Activities Between Alkb Family Rna/Dna Demethylases Through Exchange of Active-Site Residues. Angew.Chem.Int.Ed.Engl. V. 53 3659 2014.
ISSN: ISSN 1433-7851
PubMed: 24596302
DOI: 10.1002/ANIE.201310050
Page generated: Sat Oct 5 20:33:37 2024

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