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Manganese in PDB 3v0l: Crystal Structure of the Fucosylgalactoside Alpha N- Acetylgalactosaminyltransferase (Gta, Cisab Mutant L266G, G268A) in Complex with A Novel Udp-Gal Derived Inhibitor (2GW)

Enzymatic activity of Crystal Structure of the Fucosylgalactoside Alpha N- Acetylgalactosaminyltransferase (Gta, Cisab Mutant L266G, G268A) in Complex with A Novel Udp-Gal Derived Inhibitor (2GW)

All present enzymatic activity of Crystal Structure of the Fucosylgalactoside Alpha N- Acetylgalactosaminyltransferase (Gta, Cisab Mutant L266G, G268A) in Complex with A Novel Udp-Gal Derived Inhibitor (2GW):
2.4.1.37; 2.4.1.40;

Protein crystallography data

The structure of Crystal Structure of the Fucosylgalactoside Alpha N- Acetylgalactosaminyltransferase (Gta, Cisab Mutant L266G, G268A) in Complex with A Novel Udp-Gal Derived Inhibitor (2GW), PDB code: 3v0l was solved by M.M.Palcic, R.Jorgensen, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 19.70 / 1.75
Space group C 2 2 21
Cell size a, b, c (Å), α, β, γ (°) 52.430, 148.580, 78.800, 90.00, 90.00, 90.00
R / Rfree (%) 14.7 / 17.8

Manganese Binding Sites:

The binding sites of Manganese atom in the Crystal Structure of the Fucosylgalactoside Alpha N- Acetylgalactosaminyltransferase (Gta, Cisab Mutant L266G, G268A) in Complex with A Novel Udp-Gal Derived Inhibitor (2GW) (pdb code 3v0l). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total only one binding site of Manganese was determined in the Crystal Structure of the Fucosylgalactoside Alpha N- Acetylgalactosaminyltransferase (Gta, Cisab Mutant L266G, G268A) in Complex with A Novel Udp-Gal Derived Inhibitor (2GW), PDB code: 3v0l:

Manganese binding site 1 out of 1 in 3v0l

Go back to Manganese Binding Sites List in 3v0l
Manganese binding site 1 out of 1 in the Crystal Structure of the Fucosylgalactoside Alpha N- Acetylgalactosaminyltransferase (Gta, Cisab Mutant L266G, G268A) in Complex with A Novel Udp-Gal Derived Inhibitor (2GW)


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of Crystal Structure of the Fucosylgalactoside Alpha N- Acetylgalactosaminyltransferase (Gta, Cisab Mutant L266G, G268A) in Complex with A Novel Udp-Gal Derived Inhibitor (2GW) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mn1

b:26.1
occ:1.00
 O A:HOH1144 2.0 27.5 1.0
OAK A:2GW450 2.2 19.5 1.0
OD1 A:ASP213 2.3 16.7 1.0
OAL A:2GW450 2.4 23.3 1.0
OD2 A:ASP211 2.4 19.2 1.0
OD2 A:ASP213 2.5 24.8 1.0
CG A:ASP213 2.8 18.8 1.0
CG A:ASP211 3.3 16.0 1.0
PBP A:2GW450 3.4 25.2 1.0
O A:HOH1182 3.5 43.9 1.0
PBO A:2GW450 3.5 19.3 1.0
CB A:ASP211 3.6 10.3 1.0
O3' A:2GW450 3.7 13.6 1.0
OAZ A:2GW450 3.8 20.5 1.0
O2 A:2GW450 3.9 29.2 1.0
O1 A:2GW450 4.0 24.9 1.0
C5' A:2GW450 4.3 11.8 1.0
CB A:ASP213 4.3 15.0 1.0
O5' A:2GW450 4.4 15.2 1.0
OD1 A:ASP211 4.5 17.9 1.0
OAC A:2GW450 4.5 24.3 1.0
C3' A:2GW450 4.6 16.7 1.0
OAD A:2GW450 4.7 36.0 1.0
C1 A:2GW450 4.8 36.1 1.0
C4' A:2GW450 4.8 17.5 1.0
SD A:MET214 4.8 20.1 1.0
C2 A:2GW450 4.9 30.9 1.0
N A:ASP213 5.0 11.5 1.0
O A:HOH1189 5.0 39.2 1.0
O A:ASP213 5.0 14.0 1.0

Reference:

R.Jrgensen, T.Pesnot, H.J.Lee, M.M.Palcic, G.K.Wagner. Base-Modified Donor Analogues Reveal Novel Dynamic Features of A Glycosyltransferase. J.Biol.Chem. V. 288 26201 2013.
ISSN: ISSN 0021-9258
PubMed: 23836908
DOI: 10.1074/JBC.M113.465963
Page generated: Sat Oct 5 18:15:31 2024

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