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Manganese in PDB 2evm: Crystal Structure of Methionine Aminopeptidase in Complex with 5-(2,5-Dichlorophenyl)Furan-2-Carboxylic Acid

Enzymatic activity of Crystal Structure of Methionine Aminopeptidase in Complex with 5-(2,5-Dichlorophenyl)Furan-2-Carboxylic Acid

All present enzymatic activity of Crystal Structure of Methionine Aminopeptidase in Complex with 5-(2,5-Dichlorophenyl)Furan-2-Carboxylic Acid:
3.4.11.18;

Protein crystallography data

The structure of Crystal Structure of Methionine Aminopeptidase in Complex with 5-(2,5-Dichlorophenyl)Furan-2-Carboxylic Acid, PDB code: 2evm was solved by W.-J.Huang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 20.00 / 1.70
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 37.800, 60.200, 50.400, 90.00, 104.50, 90.00
R / Rfree (%) 21.5 / 24.8

Other elements in 2evm:

The structure of Crystal Structure of Methionine Aminopeptidase in Complex with 5-(2,5-Dichlorophenyl)Furan-2-Carboxylic Acid also contains other interesting chemical elements:

Chlorine (Cl) 2 atoms
Sodium (Na) 1 atom

Manganese Binding Sites:

The binding sites of Manganese atom in the Crystal Structure of Methionine Aminopeptidase in Complex with 5-(2,5-Dichlorophenyl)Furan-2-Carboxylic Acid (pdb code 2evm). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total 2 binding sites of Manganese where determined in the Crystal Structure of Methionine Aminopeptidase in Complex with 5-(2,5-Dichlorophenyl)Furan-2-Carboxylic Acid, PDB code: 2evm:
Jump to Manganese binding site number: 1; 2;

Manganese binding site 1 out of 2 in 2evm

Go back to Manganese Binding Sites List in 2evm
Manganese binding site 1 out of 2 in the Crystal Structure of Methionine Aminopeptidase in Complex with 5-(2,5-Dichlorophenyl)Furan-2-Carboxylic Acid


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of Crystal Structure of Methionine Aminopeptidase in Complex with 5-(2,5-Dichlorophenyl)Furan-2-Carboxylic Acid within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mn901

b:8.3
occ:1.00
 OXT A:FC2999 2.1 9.2 1.0
OD1 A:ASP97 2.1 10.1 1.0
OD1 A:ASP108 2.1 10.1 1.0
OE1 A:GLU235 2.2 8.9 1.0
O A:HOH1000 2.2 10.1 1.0
OD2 A:ASP97 2.3 11.3 1.0
CG A:ASP97 2.5 9.0 1.0
CG A:ASP108 3.1 8.1 1.0
CD A:GLU235 3.1 3.9 1.0
C A:FC2999 3.1 11.2 1.0
OD2 A:ASP108 3.3 6.4 1.0
OE2 A:GLU235 3.4 6.1 1.0
MN A:MN902 3.5 9.2 1.0
O A:HOH1009 3.7 11.7 1.0
CB A:FC2999 3.8 9.8 1.0
CA A:FC2999 3.8 12.6 1.0
OG1 A:THR99 3.8 12.0 1.0
CB A:ASP97 4.0 6.8 1.0
OB A:FC2999 4.1 10.2 1.0
O A:VAL98 4.2 7.8 1.0
N A:THR109 4.3 7.4 1.0
OE1 A:GLU204 4.4 15.1 1.0
O A:HOH1028 4.4 17.4 1.0
CG A:GLU235 4.4 8.0 1.0
CB A:ASP108 4.4 8.9 1.0
O A:HOH1007 4.5 11.2 1.0
O A:THR109 4.6 7.9 1.0
C A:THR109 4.7 7.5 1.0
C A:ASP108 4.7 7.2 1.0
N A:VAL98 4.7 8.0 1.0
CA A:ASP97 4.8 6.4 1.0
CA A:ASP108 4.8 9.6 1.0
C A:ASP97 4.8 6.2 1.0
C A:VAL98 4.8 6.8 1.0
CA A:THR109 4.9 8.2 1.0
CB A:GLU235 4.9 7.0 1.0
O A:HOH1013 4.9 13.8 1.0
CB A:SER110 4.9 7.1 1.0

Manganese binding site 2 out of 2 in 2evm

Go back to Manganese Binding Sites List in 2evm
Manganese binding site 2 out of 2 in the Crystal Structure of Methionine Aminopeptidase in Complex with 5-(2,5-Dichlorophenyl)Furan-2-Carboxylic Acid


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 2 of Crystal Structure of Methionine Aminopeptidase in Complex with 5-(2,5-Dichlorophenyl)Furan-2-Carboxylic Acid within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mn902

b:9.2
occ:1.00
 OE2 A:GLU235 2.2 6.1 1.0
OE2 A:GLU204 2.2 9.1 1.0
NE2 A:HIS171 2.2 10.3 1.0
OD2 A:ASP108 2.2 6.4 1.0
OB A:FC2999 2.2 10.2 1.0
OXT A:FC2999 2.3 9.2 1.0
C A:FC2999 2.6 11.2 1.0
CD A:GLU204 2.9 12.8 1.0
OE1 A:GLU204 3.0 15.1 1.0
CD2 A:HIS171 3.1 11.4 1.0
CG A:ASP108 3.2 8.1 1.0
CD A:GLU235 3.2 3.9 1.0
CE1 A:HIS171 3.3 12.9 1.0
OE1 A:GLU235 3.5 8.9 1.0
MN A:MN901 3.5 8.3 1.0
OD1 A:ASP108 3.6 10.1 1.0
OG1 A:THR202 3.7 10.9 1.0
CA A:FC2999 4.1 12.6 1.0
CG2 A:THR202 4.1 11.6 1.0
CB A:THR202 4.2 11.7 1.0
CG A:GLU204 4.3 10.3 1.0
CB A:ASP108 4.3 8.9 1.0
CG A:HIS171 4.3 11.3 1.0
ND1 A:HIS171 4.3 10.0 1.0
NE2 A:HIS178 4.4 16.8 1.0
CG A:GLU235 4.5 8.0 1.0
CE1 A:PHE177 4.6 9.1 1.0
O A:HOH1000 4.7 10.1 1.0
O A:HOH1013 4.7 13.8 1.0
CD2 A:HIS178 4.8 19.8 1.0
OA A:FC2999 4.9 13.1 1.0
CB A:GLU204 4.9 9.3 1.0

Reference:

S.X.Xie, W.J.Huang, Z.Q.Ma, M.Huang, R.P.Hanzlik, Q.Z.Ye. Structural Analysis of Metalloform-Selective Inhibition of Methionine Aminopeptidase. Acta Crystallogr.,Sect.D V. 62 425 2006.
ISSN: ISSN 0907-4449
PubMed: 16552144
DOI: 10.1107/S0907444906003878
Page generated: Sat Oct 5 14:00:45 2024

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