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Manganese in PDB 1pj3: Crystal Structure of Human Mitochondrial Nad(P)+-Dependent Malic Enzyme in A Pentary Complex with Natural Substrate Pyruvate, Cofactor Nad+, Mn++, and Allosteric Activator Fumarate.
Enzymatic activity of Crystal Structure of Human Mitochondrial Nad(P)+-Dependent Malic Enzyme in A Pentary Complex with Natural Substrate Pyruvate, Cofactor Nad+, Mn++, and Allosteric Activator Fumarate.
All present enzymatic activity of Crystal Structure of Human Mitochondrial Nad(P)+-Dependent Malic Enzyme in A Pentary Complex with Natural Substrate Pyruvate, Cofactor Nad+, Mn++, and Allosteric Activator Fumarate.:
1.1.1.39;
1.1.1.39;
Protein crystallography data
The structure of Crystal Structure of Human Mitochondrial Nad(P)+-Dependent Malic Enzyme in A Pentary Complex with Natural Substrate Pyruvate, Cofactor Nad+, Mn++, and Allosteric Activator Fumarate., PDB code: 1pj3
was solved by
X.Tao,
Z.Yang,
L.Tong,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 20.00 / 2.10 |
| Space group | C 1 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 225.828, 117.050, 111.847, 90.00, 109.57, 90.00 |
| R / Rfree (%) | 19.2 / 23.6 |
Manganese Binding Sites:
The binding sites of Manganese atom in the Crystal Structure of Human Mitochondrial Nad(P)+-Dependent Malic Enzyme in A Pentary Complex with Natural Substrate Pyruvate, Cofactor Nad+, Mn++, and Allosteric Activator Fumarate.
(pdb code 1pj3). This binding sites where shown within
5.0 Angstroms radius around Manganese atom.
In total 4 binding sites of Manganese where determined in the Crystal Structure of Human Mitochondrial Nad(P)+-Dependent Malic Enzyme in A Pentary Complex with Natural Substrate Pyruvate, Cofactor Nad+, Mn++, and Allosteric Activator Fumarate., PDB code: 1pj3:
Jump to Manganese binding site number: 1; 2; 3; 4;
In total 4 binding sites of Manganese where determined in the Crystal Structure of Human Mitochondrial Nad(P)+-Dependent Malic Enzyme in A Pentary Complex with Natural Substrate Pyruvate, Cofactor Nad+, Mn++, and Allosteric Activator Fumarate., PDB code: 1pj3:
Jump to Manganese binding site number: 1; 2; 3; 4;
Manganese binding site 1 out of 4 in 1pj3
Go back to
Manganese Binding Sites List in 1pj3
Manganese binding site 1 out
of 4 in the Crystal Structure of Human Mitochondrial Nad(P)+-Dependent Malic Enzyme in A Pentary Complex with Natural Substrate Pyruvate, Cofactor Nad+, Mn++, and Allosteric Activator Fumarate.
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Manganese with other atoms in the Mn binding
site number 1 of Crystal Structure of Human Mitochondrial Nad(P)+-Dependent Malic Enzyme in A Pentary Complex with Natural Substrate Pyruvate, Cofactor Nad+, Mn++, and Allosteric Activator Fumarate. within 5.0Å range:
|
Manganese binding site 2 out of 4 in 1pj3
Go back to
Manganese Binding Sites List in 1pj3
Manganese binding site 2 out
of 4 in the Crystal Structure of Human Mitochondrial Nad(P)+-Dependent Malic Enzyme in A Pentary Complex with Natural Substrate Pyruvate, Cofactor Nad+, Mn++, and Allosteric Activator Fumarate.
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Manganese with other atoms in the Mn binding
site number 2 of Crystal Structure of Human Mitochondrial Nad(P)+-Dependent Malic Enzyme in A Pentary Complex with Natural Substrate Pyruvate, Cofactor Nad+, Mn++, and Allosteric Activator Fumarate. within 5.0Å range:
|
Manganese binding site 3 out of 4 in 1pj3
Go back to
Manganese Binding Sites List in 1pj3
Manganese binding site 3 out
of 4 in the Crystal Structure of Human Mitochondrial Nad(P)+-Dependent Malic Enzyme in A Pentary Complex with Natural Substrate Pyruvate, Cofactor Nad+, Mn++, and Allosteric Activator Fumarate.
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Manganese with other atoms in the Mn binding
site number 3 of Crystal Structure of Human Mitochondrial Nad(P)+-Dependent Malic Enzyme in A Pentary Complex with Natural Substrate Pyruvate, Cofactor Nad+, Mn++, and Allosteric Activator Fumarate. within 5.0Å range:
|
Manganese binding site 4 out of 4 in 1pj3
Go back to
Manganese Binding Sites List in 1pj3
Manganese binding site 4 out
of 4 in the Crystal Structure of Human Mitochondrial Nad(P)+-Dependent Malic Enzyme in A Pentary Complex with Natural Substrate Pyruvate, Cofactor Nad+, Mn++, and Allosteric Activator Fumarate.
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Manganese with other atoms in the Mn binding
site number 4 of Crystal Structure of Human Mitochondrial Nad(P)+-Dependent Malic Enzyme in A Pentary Complex with Natural Substrate Pyruvate, Cofactor Nad+, Mn++, and Allosteric Activator Fumarate. within 5.0Å range:
|
Reference:
X.Tao,
Z.Yang,
L.Tong.
Crystal Structures of Substrate Complexes of Malic Enzyme and Insights Into the Catalytic Mechanism. Structure V. 11 1141 2003.
ISSN: ISSN 0969-2126
PubMed: 12962632
DOI: 10.1016/S0969-2126(03)00168-0
Page generated: Sat Oct 5 12:06:37 2024
ISSN: ISSN 0969-2126
PubMed: 12962632
DOI: 10.1016/S0969-2126(03)00168-0
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