Manganese in PDB 9mip: Cryoem Structure of the Protein Phasphatase 2A (Aalpha-B56GAMMA- Calpha) Holoenzyme Complex

All present enzymatic activity of Cryoem Structure of the Protein Phasphatase 2A (Aalpha-B56GAMMA- Calpha) Holoenzyme Complex:
3.1.3.16;

The binding sites of Manganese atom in the Cryoem Structure of the Protein Phasphatase 2A (Aalpha-B56GAMMA- Calpha) Holoenzyme Complex (pdb code 9mip). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total 2 binding sites of Manganese where determined in the Cryoem Structure of the Protein Phasphatase 2A (Aalpha-B56GAMMA- Calpha) Holoenzyme Complex, PDB code: 9mip:
Jump to Manganese binding site number: 1; 2;

Manganese binding site 1 out of 2 in the Cryoem Structure of the Protein Phasphatase 2A (Aalpha-B56GAMMA- Calpha) Holoenzyme Complex


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of Cryoem Structure of the Protein Phasphatase 2A (Aalpha-B56GAMMA- Calpha) Holoenzyme Complex within 5.0Å range: probe atom residue distance (Å) B Occ C:Mn401 b:188.2 occ:1.00 OD1 C:ASN117 1.8 170.8 1.0 OD2 C:ASP85 2.1 181.5 1.0 ND1 C:HIS241 2.3 155.8 1.0 NE2 C:HIS167 2.6 171.9 1.0 CE1 C:HIS241 2.9 155.9 1.0 CG C:ASN117 2.9 170.6 1.0 CG C:ASP85 3.0 181.2 1.0 CG C:HIS241 3.1 155.4 1.0 MN C:MN402 3.2 221.8 1.0 CE1 C:HIS167 3.2 172.1 1.0 OD1 C:ASP85 3.3 181.2 1.0 ND2 C:ASN117 3.5 170.7 1.0 CB C:HIS241 3.6 155.2 1.0 CA C:HIS241 3.6 155.2 1.0 CD2 C:HIS167 3.8 171.8 1.0 NE2 C:HIS241 3.9 155.5 1.0 CD2 C:HIS241 3.9 155.3 1.0 O C:HIS241 4.1 155.4 1.0 CB C:ASN117 4.2 170.8 1.0 C C:HIS241 4.3 155.2 1.0 N C:ASN117 4.4 170.8 1.0 OD2 C:ASP57 4.4 175.5 1.0 CB C:ASP85 4.4 180.8 1.0 ND1 C:HIS167 4.5 171.9 1.0 N C:HIS241 4.7 155.2 1.0 CE1 C:HIS118 4.8 153.7 1.0 CG C:HIS167 4.8 171.6 1.0 CA C:ASN117 4.8 170.7 1.0 O C:LEU199 4.8 180.3 1.0 NE2 C:HIS118 4.9 153.7 1.0 ND1 C:HIS118 4.9 153.8 1.0

Manganese binding site 2 out of 2 in the Cryoem Structure of the Protein Phasphatase 2A (Aalpha-B56GAMMA- Calpha) Holoenzyme Complex


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 2 of Cryoem Structure of the Protein Phasphatase 2A (Aalpha-B56GAMMA- Calpha) Holoenzyme Complex within 5.0Å range: probe atom residue distance (Å) B Occ C:Mn402 b:221.8 occ:1.00 OD2 C:ASP57 2.4 175.5 1.0 NE2 C:HIS59 2.4 175.5 1.0 OD2 C:ASP85 2.4 181.5 1.0 CE1 C:HIS59 2.8 174.8 1.0 MN C:MN401 3.2 188.2 1.0 CG C:ASP85 3.5 181.2 1.0 CG C:ASP57 3.5 175.1 1.0 CD2 C:HIS59 3.7 175.5 1.0 O C:HIS241 3.8 155.4 1.0 CB C:ASP85 3.9 180.8 1.0 CE1 C:HIS118 3.9 153.7 1.0 ND1 C:HIS59 4.0 174.2 1.0 CB C:ASP57 4.1 174.9 1.0 ND1 C:HIS118 4.2 153.8 1.0 ND1 C:HIS241 4.2 155.8 1.0 CG C:HIS59 4.4 174.7 1.0 OD1 C:ASP57 4.6 175.2 1.0 OD1 C:ASN117 4.6 170.8 1.0 OD1 C:ASP85 4.6 181.2 1.0 C C:HIS241 4.7 155.2 1.0 CA C:HIS241 4.7 155.2 1.0 CE1 C:PHE260 4.8 174.8 1.0 NE2 C:HIS118 4.8 153.7 1.0 CE1 C:HIS241 4.8 155.9 1.0 CE1 C:HIS167 4.8 172.1 1.0 N C:ASP85 4.8 180.9 1.0 O C:ALA240 4.9 167.2 1.0 CA C:ASP85 4.9 180.7 1.0

A.Day, W.Huang, D.Leonard, C.M.O'connor, G.Narla, E.Ogris, D.J.Taylor. Regulatory Mechanisms of PP2A Complex Assembly Driven By Physiochemical Differences in A-Subunit Isoforms To Be Published.