Manganese in PDB 9mf5: Cryoem Structure of the Protein Phosphatase 2A (Abeta-B56GAMMA-Calpha) Holoenzyme Complex

All present enzymatic activity of Cryoem Structure of the Protein Phosphatase 2A (Abeta-B56GAMMA-Calpha) Holoenzyme Complex:
3.1.3.16;

The binding sites of Manganese atom in the Cryoem Structure of the Protein Phosphatase 2A (Abeta-B56GAMMA-Calpha) Holoenzyme Complex (pdb code 9mf5). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total 2 binding sites of Manganese where determined in the Cryoem Structure of the Protein Phosphatase 2A (Abeta-B56GAMMA-Calpha) Holoenzyme Complex, PDB code: 9mf5:
Jump to Manganese binding site number: 1; 2;

Manganese binding site 1 out of 2 in the Cryoem Structure of the Protein Phosphatase 2A (Abeta-B56GAMMA-Calpha) Holoenzyme Complex


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of Cryoem Structure of the Protein Phosphatase 2A (Abeta-B56GAMMA-Calpha) Holoenzyme Complex within 5.0Å range: probe atom residue distance (Å) B Occ C:Mn401 b:193.6 occ:1.00 OD2 C:ASP85 2.1 158.5 1.0 OD2 C:ASP57 2.2 152.6 1.0 NE2 C:HIS59 2.3 144.4 1.0 CE1 C:HIS59 3.1 142.4 1.0 CG C:ASP85 3.2 156.6 1.0 CG C:ASP57 3.3 147.3 1.0 CD2 C:HIS59 3.4 138.4 1.0 CB C:ASP85 3.6 154.8 1.0 MN C:MN402 3.7 152.4 1.0 CB C:ASP57 3.9 136.3 1.0 O C:HIS241 4.0 133.4 1.0 CE1 C:PHE260 4.0 140.9 1.0 CD2 C:HIS118 4.1 125.1 1.0 CZ C:PHE260 4.1 136.8 1.0 OD1 C:ASP57 4.2 152.6 1.0 NE2 C:HIS167 4.2 144.5 1.0 NE2 C:HIS118 4.3 124.7 1.0 ND1 C:HIS59 4.3 136.1 1.0 OD1 C:ASP85 4.3 156.6 1.0 CG C:HIS59 4.5 129.9 1.0 OH C:TYR265 4.6 157.1 1.0 OD1 C:ASN117 4.6 143.5 1.0 O C:ALA240 4.7 138.6 1.0 CD2 C:HIS241 4.7 143.7 1.0 C C:HIS241 4.8 137.0 1.0 CA C:HIS241 4.8 136.3 1.0

Manganese binding site 2 out of 2 in the Cryoem Structure of the Protein Phosphatase 2A (Abeta-B56GAMMA-Calpha) Holoenzyme Complex


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 2 of Cryoem Structure of the Protein Phosphatase 2A (Abeta-B56GAMMA-Calpha) Holoenzyme Complex within 5.0Å range: probe atom residue distance (Å) B Occ C:Mn402 b:152.4 occ:1.00 OD1 C:ASN117 1.9 143.5 1.0 CD2 C:HIS241 2.1 143.7 1.0 CE1 C:HIS167 2.4 146.6 1.0 NE2 C:HIS167 2.5 144.5 1.0 CG C:ASN117 2.6 152.4 1.0 OD2 C:ASP85 2.7 158.5 1.0 NE2 C:HIS241 2.9 144.3 1.0 CG C:HIS241 3.0 140.4 1.0 ND2 C:ASN117 3.1 156.0 1.0 CG C:ASP85 3.5 156.6 1.0 CB C:HIS241 3.6 140.1 1.0 OD1 C:ASP85 3.6 156.6 1.0 MN C:MN401 3.7 193.6 1.0 ND1 C:HIS167 3.7 151.4 1.0 CB C:ASN117 3.7 151.7 1.0 CA C:HIS241 3.8 136.3 1.0 CD2 C:HIS167 3.9 146.1 1.0 CE1 C:HIS241 4.0 135.3 1.0 ND1 C:HIS241 4.0 135.6 1.0 O C:HIS241 4.1 133.4 1.0 CD2 C:HIS118 4.1 125.1 1.0 N C:ASN117 4.2 149.5 1.0 O C:LEU199 4.4 135.3 1.0 C C:HIS241 4.4 137.0 1.0 CG C:HIS167 4.5 145.8 1.0 OD2 C:ASP57 4.5 152.6 1.0 CA C:ASN117 4.5 148.5 1.0 N C:HIS118 4.8 127.4 1.0 NE2 C:HIS118 4.8 124.7 1.0 CB C:ASP85 5.0 154.8 1.0 N C:HIS241 5.0 132.9 1.0

A.Day, W.Huang, D.Leonard, C.M.O'connor, G.Narla, E.Ogris, D.J.Taylor. Regulatory Mechanisms of PP2A Complex Assembly Driven By Physiochemical Differences in A-Subunit Isoforms To Be Published.