Manganese in PDB 9cah: Human TOP3B-TDRD3 Complex

All present enzymatic activity of Human TOP3B-TDRD3 Complex:
5.6.2.1;

The structure of Human TOP3B-TDRD3 Complex also contains other interesting chemical elements:

Zinc

(Zn)

3 atoms

The binding sites of Manganese atom in the Human TOP3B-TDRD3 Complex (pdb code 9cah). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total only one binding site of Manganese was determined in the Human TOP3B-TDRD3 Complex, PDB code: 9cah:

Manganese binding site 1 out of 1 in the Human TOP3B-TDRD3 Complex


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of Human TOP3B-TDRD3 Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Mn801 b:78.8 occ:1.00 OE2 A:GLU9 2.0 67.3 1.0 OD2 A:ASP117 2.1 67.3 1.0 CG A:ASP117 3.2 67.3 1.0 CD A:GLU9 3.2 67.3 1.0 OE1 A:GLU9 3.7 67.3 1.0 OD1 A:ASP117 3.8 67.3 1.0 OH A:TYR336 4.0 67.3 1.0 OD2 A:ASP119 4.0 67.5 1.0 OE2 A:GLU326 4.2 67.3 1.0 CB A:ASP117 4.2 67.3 1.0 CG A:GLU9 4.4 67.3 1.0 OD1 A:ASP119 4.7 67.5 1.0 CG A:ASP119 4.8 67.5 1.0 NH2 A:ARG338 5.0 67.3 1.0

X.Yang, X.Chen, W.Yang, Y.Pommier. Structural Insights Into Human Topoisomerase 3 Beta Dna and Rna Catalysis and Nucleic Acid Gate Dynamics. Nat Commun V. 16 834 2025.
ISSN: ESSN 2041-1723
PubMed: 39828754
DOI: 10.1038/S41467-025-55959-Y