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Atomistry » Manganese » PDB 8kfj-8q1k » 8ppj | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Manganese » PDB 8kfj-8q1k » 8ppj » |
Manganese in PDB 8ppj: Human Inositol 1,4,5-Trisphosphate 3-Kinase A (IP3K) Catalytic Domain in Complex with Beta-D-Glucopyranosylmethanol 3,4,6,1'- Tetrakisphosphate/Adp/Mn After ReactionEnzymatic activity of Human Inositol 1,4,5-Trisphosphate 3-Kinase A (IP3K) Catalytic Domain in Complex with Beta-D-Glucopyranosylmethanol 3,4,6,1'- Tetrakisphosphate/Adp/Mn After Reaction
All present enzymatic activity of Human Inositol 1,4,5-Trisphosphate 3-Kinase A (IP3K) Catalytic Domain in Complex with Beta-D-Glucopyranosylmethanol 3,4,6,1'- Tetrakisphosphate/Adp/Mn After Reaction:
2.7.1.127; Protein crystallography data
The structure of Human Inositol 1,4,5-Trisphosphate 3-Kinase A (IP3K) Catalytic Domain in Complex with Beta-D-Glucopyranosylmethanol 3,4,6,1'- Tetrakisphosphate/Adp/Mn After Reaction, PDB code: 8ppj
was solved by
M.A.Marquez-Monino,
B.Gonzalez,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Manganese Binding Sites:
The binding sites of Manganese atom in the Human Inositol 1,4,5-Trisphosphate 3-Kinase A (IP3K) Catalytic Domain in Complex with Beta-D-Glucopyranosylmethanol 3,4,6,1'- Tetrakisphosphate/Adp/Mn After Reaction
(pdb code 8ppj). This binding sites where shown within
5.0 Angstroms radius around Manganese atom.
In total 4 binding sites of Manganese where determined in the Human Inositol 1,4,5-Trisphosphate 3-Kinase A (IP3K) Catalytic Domain in Complex with Beta-D-Glucopyranosylmethanol 3,4,6,1'- Tetrakisphosphate/Adp/Mn After Reaction, PDB code: 8ppj: Jump to Manganese binding site number: 1; 2; 3; 4; Manganese binding site 1 out of 4 in 8ppjGo back to Manganese Binding Sites List in 8ppj
Manganese binding site 1 out
of 4 in the Human Inositol 1,4,5-Trisphosphate 3-Kinase A (IP3K) Catalytic Domain in Complex with Beta-D-Glucopyranosylmethanol 3,4,6,1'- Tetrakisphosphate/Adp/Mn After Reaction
Mono view Stereo pair view
Manganese binding site 2 out of 4 in 8ppjGo back to Manganese Binding Sites List in 8ppj
Manganese binding site 2 out
of 4 in the Human Inositol 1,4,5-Trisphosphate 3-Kinase A (IP3K) Catalytic Domain in Complex with Beta-D-Glucopyranosylmethanol 3,4,6,1'- Tetrakisphosphate/Adp/Mn After Reaction
Mono view Stereo pair view
Manganese binding site 3 out of 4 in 8ppjGo back to Manganese Binding Sites List in 8ppj
Manganese binding site 3 out
of 4 in the Human Inositol 1,4,5-Trisphosphate 3-Kinase A (IP3K) Catalytic Domain in Complex with Beta-D-Glucopyranosylmethanol 3,4,6,1'- Tetrakisphosphate/Adp/Mn After Reaction
Mono view Stereo pair view
Manganese binding site 4 out of 4 in 8ppjGo back to Manganese Binding Sites List in 8ppj
Manganese binding site 4 out
of 4 in the Human Inositol 1,4,5-Trisphosphate 3-Kinase A (IP3K) Catalytic Domain in Complex with Beta-D-Glucopyranosylmethanol 3,4,6,1'- Tetrakisphosphate/Adp/Mn After Reaction
Mono view Stereo pair view
Reference:
M.A.Marquez-Monino,
R.Ortega-Garcia,
H.Whitfield,
A.M.Riley,
L.Infantes,
S.W.Garrett,
M.L.Shipton,
C.A.Brearley,
B.V.L.Potter,
B.Gonzalez.
Substrate Promiscuity of Inositol 1,4,5-Trisphosphate Kinase Driven By Structurally-Modified Ligands and Active Site Plasticity Nat Commun V. 15 1502 2024.
Page generated: Sun Oct 6 13:34:25 2024
ISSN: ESSN 2041-1723 DOI: 10.1038/S41467-024-45917-5 |
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