Manganese in PDB 8jyh: Crystal Structure of Engineered Hiv-1 Reverse Transcriptase Rnase H Domain Complexed with Laccaic Acid C

All present enzymatic activity of Crystal Structure of Engineered Hiv-1 Reverse Transcriptase Rnase H Domain Complexed with Laccaic Acid C:
3.1.26.13;

The structure of Crystal Structure of Engineered Hiv-1 Reverse Transcriptase Rnase H Domain Complexed with Laccaic Acid C, PDB code: 8jyh was solved by Y.Ito, H.Lu, M.Kitajima, H.Ishikawa, Y.Nakata, Y.Iwatani, T.Hoshino, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	43.73 / 2.21
Space group	P 41 21 2
Cell size a, b, c (Å), α, β, γ (°)	61.85, 61.85, 82.337, 90, 90, 90
R / Rfree (%)	22.8 / 28.2

The structure of Crystal Structure of Engineered Hiv-1 Reverse Transcriptase Rnase H Domain Complexed with Laccaic Acid C also contains other interesting chemical elements:

Zinc

(Zn)

2 atoms

The binding sites of Manganese atom in the Crystal Structure of Engineered Hiv-1 Reverse Transcriptase Rnase H Domain Complexed with Laccaic Acid C (pdb code 8jyh). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total 2 binding sites of Manganese where determined in the Crystal Structure of Engineered Hiv-1 Reverse Transcriptase Rnase H Domain Complexed with Laccaic Acid C, PDB code: 8jyh:
Jump to Manganese binding site number: 1; 2;

Manganese binding site 1 out of 2 in the Crystal Structure of Engineered Hiv-1 Reverse Transcriptase Rnase H Domain Complexed with Laccaic Acid C


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of Crystal Structure of Engineered Hiv-1 Reverse Transcriptase Rnase H Domain Complexed with Laccaic Acid C within 5.0Å range: probe atom residue distance (Å) B Occ A:Mn201 b:51.8 occ:1.00 OAY A:V96203 1.8 200.2 1.0 OAX A:V96203 1.8 198.5 1.0 OD1 A:ASP23 2.1 53.6 1.0 OE2 A:GLU58 2.1 84.1 1.0 OD1 A:ASP78 2.2 78.7 1.0 CAG A:V96203 2.8 197.1 1.0 CAK A:V96203 2.9 199.4 1.0 CG A:ASP78 2.9 83.0 1.0 CD A:GLU58 3.0 72.5 1.0 CG A:ASP23 3.1 63.0 1.0 OD2 A:ASP78 3.1 82.5 1.0 MN A:MN202 3.1 87.4 1.0 CAH A:V96203 3.2 197.6 1.0 OE1 A:GLU58 3.2 67.1 1.0 OD2 A:ASP23 3.4 71.6 1.0 O A:GLY24 3.6 69.2 1.0 CAD A:V96203 4.0 195.3 1.0 O A:HOH301 4.0 59.8 1.0 CAL A:V96203 4.1 199.8 1.0 CAC A:V96203 4.2 195.3 1.0 CB A:ASP78 4.3 74.0 1.0 N A:GLY24 4.3 55.6 1.0 OAZ A:V96203 4.3 201.1 1.0 CG A:GLU58 4.4 58.7 1.0 CB A:ASP23 4.4 56.8 1.0 CAI A:V96203 4.6 210.8 1.0 CA A:ASP23 4.7 52.2 1.0 C A:GLY24 4.7 63.1 1.0 C A:ASP78 4.8 66.0 1.0 O A:ASP78 4.9 69.8 1.0 CA A:ASP78 4.9 60.4 1.0

Manganese binding site 2 out of 2 in the Crystal Structure of Engineered Hiv-1 Reverse Transcriptase Rnase H Domain Complexed with Laccaic Acid C


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 2 of Crystal Structure of Engineered Hiv-1 Reverse Transcriptase Rnase H Domain Complexed with Laccaic Acid C within 5.0Å range: probe atom residue distance (Å) B Occ A:Mn202 b:87.4 occ:1.00 OAY A:V96203 1.8 200.2 1.0 OAZ A:V96203 2.0 201.1 1.0 OD2 A:ASP23 2.0 71.6 1.0 OD1 A:ASP139 2.4 96.2 1.0 CAK A:V96203 2.6 199.4 1.0 OD2 A:ASP78 2.7 82.5 1.0 CAL A:V96203 2.7 199.8 1.0 CG A:ASP23 2.9 63.0 1.0 MN A:MN201 3.1 51.8 1.0 CG A:ASP139 3.2 87.8 1.0 OD1 A:ASP23 3.2 53.6 1.0 CB A:ASP139 3.7 69.3 1.0 CG A:ASP78 3.7 83.0 1.0 CAH A:V96203 4.0 197.6 1.0 OD1 A:ASP78 4.0 78.7 1.0 CA A:ASP139 4.0 70.9 1.0 CAM A:V96203 4.1 207.6 1.0 OD2 A:ASP139 4.1 103.7 1.0 OAX A:V96203 4.2 198.5 1.0 CB A:ASP23 4.3 56.8 1.0 ND2 A:ASN135 4.4 58.0 1.0 CAG A:V96203 4.6 197.1 1.0 CD1 A:V96203 4.6 202.7 1.0 OD1 A:ASN135 4.7 57.9 1.0 O A:GLY24 4.9 69.2 1.0 CBA A:V96203 4.9 208.4 1.0 N A:ASP139 4.9 61.9 1.0 CB A:ALA128 4.9 111.1 1.0 CB A:ASP78 5.0 74.0 1.0 CAN A:V96203 5.0 215.1 1.0 CAI A:V96203 5.0 210.8 1.0 CG A:ASN135 5.0 60.6 1.0 OE2 A:GLU58 5.0 84.1 1.0

Y.Ito, H.Lu, M.Kitajima, H.Ishikawa, Y.Nakata, Y.Iwatani, T.Hoshino. Crystal Structure of Engineered Hiv-1 Reverse Transcriptase Rnase H Domain Complexed with Laccaic Acid C To Be Published.