Manganese in PDB 8gwb: A Mechanism For Sars-Cov-2 Rna Capping and Its Inhibition By Nucleotide Analogue Inhibitors

All present enzymatic activity of A Mechanism For Sars-Cov-2 Rna Capping and Its Inhibition By Nucleotide Analogue Inhibitors:
2.7.7.48;

The structure of A Mechanism For Sars-Cov-2 Rna Capping and Its Inhibition By Nucleotide Analogue Inhibitors also contains other interesting chemical elements:

Zinc

(Zn)

8 atoms

The binding sites of Manganese atom in the A Mechanism For Sars-Cov-2 Rna Capping and Its Inhibition By Nucleotide Analogue Inhibitors (pdb code 8gwb). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total 2 binding sites of Manganese where determined in the A Mechanism For Sars-Cov-2 Rna Capping and Its Inhibition By Nucleotide Analogue Inhibitors, PDB code: 8gwb:
Jump to Manganese binding site number: 1; 2;

Manganese binding site 1 out of 2 in the A Mechanism For Sars-Cov-2 Rna Capping and Its Inhibition By Nucleotide Analogue Inhibitors


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of A Mechanism For Sars-Cov-2 Rna Capping and Its Inhibition By Nucleotide Analogue Inhibitors within 5.0Å range: probe atom residue distance (Å) B Occ A:Mn1003 b:73.1 occ:1.00 O M:HOH102 2.1 51.7 1.0 OD1 A:ASN209 2.3 51.2 1.0 OD2 A:ASP218 2.3 40.0 1.0 OP1 M:A1 2.4 78.6 1.0 OD2 A:ASP208 3.2 57.5 1.0 CG A:ASN209 3.3 48.2 1.0 CG A:ASP218 3.4 36.7 1.0 ND2 A:ASN209 3.7 52.9 1.0 MN A:MN1004 3.9 65.4 1.0 O A:HOH1101 3.9 30.0 1.0 P M:A1 4.0 76.9 1.0 CB A:ASP218 4.0 30.5 1.0 CG A:ASP208 4.1 53.5 1.0 OD1 A:ASP218 4.4 43.4 1.0 O A:ASP208 4.5 56.4 1.0 N G:ASN1 4.5 38.6 1.0 CB A:ASN209 4.5 47.6 1.0 C A:ASP208 4.6 48.6 1.0 N A:ASN209 4.6 49.3 1.0 O5' M:A1 4.6 78.8 1.0 O M:HOH103 4.7 23.8 1.0 CA A:ASN209 4.7 43.2 1.0 CB A:ASP208 4.8 50.2 1.0 OP2 M:A1 4.8 75.2 1.0 O A:HOH1102 4.8 42.4 1.0 OD1 A:ASP208 4.8 53.7 1.0

Manganese binding site 2 out of 2 in the A Mechanism For Sars-Cov-2 Rna Capping and Its Inhibition By Nucleotide Analogue Inhibitors


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 2 of A Mechanism For Sars-Cov-2 Rna Capping and Its Inhibition By Nucleotide Analogue Inhibitors within 5.0Å range: probe atom residue distance (Å) B Occ A:Mn1004 b:65.4 occ:1.00 O A:HOH1103 2.1 24.4 1.0 OD1 A:ASP218 2.2 43.4 1.0 OD2 A:ASP218 2.3 40.0 1.0 CG A:ASP218 2.5 36.7 1.0 O M:HOH103 2.9 23.8 1.0 OP1 M:A1 3.5 78.6 1.0 OP2 M:A1 3.5 75.2 1.0 MN A:MN1003 3.9 73.1 1.0 P M:A1 3.9 76.9 1.0 CB A:ASP218 4.0 30.5 1.0 N G:ASN1 4.3 38.6 1.0 O A:ASP218 4.5 39.4 1.0 O M:HOH102 4.5 51.7 1.0 N A:GLY220 4.7 33.1 1.0 CA A:GLY220 4.8 34.3 1.0 CA A:ASP218 4.8 35.4 1.0 OD1 A:ASN209 4.8 51.2 1.0 C A:ASP218 4.9 38.5 1.0 C A:GLY220 5.0 36.3 1.0

L.Yan, Y.Huang, J.Ge, Z.Liu, P.Lu, B.Huang, S.Gao, J.Wang, L.Tan, S.Ye, F.Yu, W.Lan, S.Xu, F.Zhou, L.Shi, L.W.Guddat, Y.Gao, Z.Rao, Z.Lou. A Mechanism For Sars-Cov-2 Rna Capping and Its Inhibition By Nucleotide Analog Inhibitors. Cell V. 185 4347 2022.
ISSN: ISSN 1097-4172
PubMed: 36335936
DOI: 10.1016/J.CELL.2022.09.037