Manganese in PDB 8gw1: A Mechanism For Sars-Cov-2 Rna Capping and Its Inhibition By Nucleotide Analogue Inhibitors

All present enzymatic activity of A Mechanism For Sars-Cov-2 Rna Capping and Its Inhibition By Nucleotide Analogue Inhibitors:
2.7.7.48; 3.4.19.12; 3.4.22.69; 3.6.4.12; 3.6.4.13;

The structure of A Mechanism For Sars-Cov-2 Rna Capping and Its Inhibition By Nucleotide Analogue Inhibitors also contains other interesting chemical elements:

Zinc

(Zn)

8 atoms

The binding sites of Manganese atom in the A Mechanism For Sars-Cov-2 Rna Capping and Its Inhibition By Nucleotide Analogue Inhibitors (pdb code 8gw1). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total 2 binding sites of Manganese where determined in the A Mechanism For Sars-Cov-2 Rna Capping and Its Inhibition By Nucleotide Analogue Inhibitors, PDB code: 8gw1:
Jump to Manganese binding site number: 1; 2;

Manganese binding site 1 out of 2 in the A Mechanism For Sars-Cov-2 Rna Capping and Its Inhibition By Nucleotide Analogue Inhibitors


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of A Mechanism For Sars-Cov-2 Rna Capping and Its Inhibition By Nucleotide Analogue Inhibitors within 5.0Å range: probe atom residue distance (Å) B Occ A:Mn1003 b:69.3 occ:1.00 OD2 A:ASP218 2.4 70.3 1.0 OD1 A:ASP218 2.5 69.1 1.0 OP2 G:U0 2.7 89.9 1.0 CG A:ASP218 2.8 69.7 1.0 OD2 A:ASP221 4.0 65.9 1.0 MN A:MN1004 4.0 131.4 1.0 P G:U0 4.2 90.0 1.0 CB A:ASP218 4.3 71.3 1.0 CA A:GLY220 4.5 45.2 1.0 O A:HOH1101 4.5 63.2 1.0 N A:GLY220 4.8 48.1 1.0 N G:ASN1 4.8 48.5 1.0 O A:ASP218 4.9 70.2 1.0 OP1 G:U0 5.0 92.6 1.0

Manganese binding site 2 out of 2 in the A Mechanism For Sars-Cov-2 Rna Capping and Its Inhibition By Nucleotide Analogue Inhibitors


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 2 of A Mechanism For Sars-Cov-2 Rna Capping and Its Inhibition By Nucleotide Analogue Inhibitors within 5.0Å range: probe atom residue distance (Å) B Occ A:Mn1004 b:131.4 occ:1.00 OD2 A:ASP218 2.0 70.3 1.0 OD1 A:ASN209 2.0 74.4 1.0 ND2 A:ASN209 2.1 75.0 1.0 CG A:ASN209 2.3 73.6 1.0 CG A:ASP218 2.9 69.7 1.0 OP1 G:U0 3.1 92.6 1.0 CB A:ASP218 3.2 71.3 1.0 O A:HOH1101 3.5 63.2 1.0 OD2 A:ASP208 3.6 69.9 1.0 OP2 G:U0 3.8 89.9 1.0 CB A:ASN209 3.8 75.2 1.0 MN A:MN1003 4.0 69.3 1.0 OD1 A:ASP218 4.0 69.1 1.0 P G:U0 4.1 90.0 1.0 O A:ASP208 4.6 69.1 1.0 CA A:ASN209 4.7 77.7 1.0 CG A:ASP208 4.7 69.6 1.0 O A:ASP218 4.7 70.2 1.0 CA A:ASP218 4.7 70.4 1.0 OG1 A:THR206 4.9 53.8 1.0 C A:ASP208 5.0 66.9 1.0 N A:ASN209 5.0 75.0 1.0

L.Yan, Y.Huang, J.Ge, Z.Liu, P.Lu, B.Huang, S.Gao, J.Wang, L.Tan, S.Ye, F.Yu, W.Lan, S.Xu, F.Zhou, L.Shi, L.W.Guddat, Y.Gao, Z.Rao, Z.Lou. A Mechanism For Sars-Cov-2 Rna Capping and Its Inhibition By Nucleotide Analog Inhibitors. Cell V. 185 4347 2022.
ISSN: ISSN 1097-4172
PubMed: 36335936
DOI: 10.1016/J.CELL.2022.09.037