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Manganese in PDB 8d3l: Type I-C CAS4-CAS1-CAS2 Complex Bound to A Pam/Pam Prespacer

Enzymatic activity of Type I-C CAS4-CAS1-CAS2 Complex Bound to A Pam/Pam Prespacer

All present enzymatic activity of Type I-C CAS4-CAS1-CAS2 Complex Bound to A Pam/Pam Prespacer:
3.1.12.1;

Other elements in 8d3l:

The structure of Type I-C CAS4-CAS1-CAS2 Complex Bound to A Pam/Pam Prespacer also contains other interesting chemical elements:

Iron (Fe) 8 atoms

Manganese Binding Sites:

The binding sites of Manganese atom in the Type I-C CAS4-CAS1-CAS2 Complex Bound to A Pam/Pam Prespacer (pdb code 8d3l). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total 2 binding sites of Manganese where determined in the Type I-C CAS4-CAS1-CAS2 Complex Bound to A Pam/Pam Prespacer, PDB code: 8d3l:
Jump to Manganese binding site number: 1; 2;

Manganese binding site 1 out of 2 in 8d3l

Go back to Manganese Binding Sites List in 8d3l
Manganese binding site 1 out of 2 in the Type I-C CAS4-CAS1-CAS2 Complex Bound to A Pam/Pam Prespacer


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of Type I-C CAS4-CAS1-CAS2 Complex Bound to A Pam/Pam Prespacer within 5.0Å range:
probe atom residue distance (Å) B Occ
I:Mn302

b:54.3
occ:1.00
OP1 H:DG29 1.8 13.5 1.0
OD2 I:ASP82 2.0 29.8 1.0
O I:TYR109 2.4 29.2 1.0
P H:DG29 3.0 13.5 1.0
CG I:ASP82 3.1 29.8 1.0
C I:TYR109 3.4 29.2 1.0
OE1 I:GLU108 3.5 28.1 1.0
OD1 I:ASP82 3.6 29.8 1.0
N I:TYR109 3.7 29.2 1.0
O3' H:DT28 3.7 12.1 1.0
OP2 H:DG29 3.7 13.5 1.0
CA I:TYR109 4.1 29.2 1.0
O5' H:DG29 4.3 13.5 1.0
ND1 I:HIS47 4.4 15.5 1.0
CB I:GLU108 4.4 28.1 1.0
CB I:ASP82 4.4 29.8 1.0
C I:GLU108 4.5 28.1 1.0
N I:LYS110 4.5 19.4 1.0
CB I:TYR109 4.6 29.2 1.0
C5' H:DG29 4.7 13.5 1.0
CD I:GLU108 4.7 28.1 1.0
CA I:GLU108 4.8 28.1 1.0
NZ I:LYS110 4.8 19.4 1.0
CA I:LYS110 4.9 19.4 1.0
C3' H:DT28 4.9 12.1 1.0

Manganese binding site 2 out of 2 in 8d3l

Go back to Manganese Binding Sites List in 8d3l
Manganese binding site 2 out of 2 in the Type I-C CAS4-CAS1-CAS2 Complex Bound to A Pam/Pam Prespacer


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 2 of Type I-C CAS4-CAS1-CAS2 Complex Bound to A Pam/Pam Prespacer within 5.0Å range:
probe atom residue distance (Å) B Occ
J:Mn302

b:50.0
occ:1.00
OP1 G:DG29 2.1 29.1 1.0
O J:TYR109 2.2 5.0 1.0
C J:TYR109 3.4 5.0 1.0
P G:DG29 3.6 29.1 1.0
OD1 J:ASP82 3.6 9.1 1.0
N J:TYR109 3.9 5.0 1.0
CA J:TYR109 4.0 5.0 1.0
CB J:TYR109 4.0 5.0 1.0
CG J:ASP82 4.1 9.1 1.0
O5' G:DG29 4.1 29.1 1.0
ND1 J:HIS47 4.2 11.2 1.0
O3' G:DT28 4.3 35.6 1.0
CG J:GLU108 4.4 5.7 1.0
N J:LYS110 4.5 3.7 1.0
OD2 J:ASP82 4.6 9.1 1.0
OP2 G:DG29 4.7 29.1 1.0
CE1 J:HIS47 4.7 11.2 1.0
CB J:ASP82 4.7 9.1 1.0
CG J:LYS110 4.8 3.7 1.0
CA J:LYS110 4.8 3.7 1.0
C J:GLU108 4.9 5.7 1.0
CD J:GLU108 5.0 5.7 1.0

Reference:

Y.Dhingra, S.K.Suresh, P.Juneja, D.G.Sashital. Pam Binding Ensures Orientational Integration During CAS4-CAS1-CAS2-Mediated Crispr Adaptation. Mol.Cell V. 82 4353 2022.
ISSN: ISSN 1097-2765
PubMed: 36272411
DOI: 10.1016/J.MOLCEL.2022.09.030
Page generated: Sun Oct 6 11:29:29 2024

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