Manganese in PDB 8coh: Structure of the Complement C5 Specific Nanobody Tpp-3444

The structure of Structure of the Complement C5 Specific Nanobody Tpp-3444, PDB code: 8coh was solved by D.V.Pedersen, G.R.Andersen, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	36.44 / 1.30
Space group	P 41 21 2
Cell size a, b, c (Å), α, β, γ (°)	81.489, 81.489, 36.601, 90, 90, 90
R / Rfree (%)	14.6 / 17.5

The binding sites of Manganese atom in the Structure of the Complement C5 Specific Nanobody Tpp-3444 (pdb code 8coh). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total only one binding site of Manganese was determined in the Structure of the Complement C5 Specific Nanobody Tpp-3444, PDB code: 8coh:

Manganese binding site 1 out of 1 in the Structure of the Complement C5 Specific Nanobody Tpp-3444


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of Structure of the Complement C5 Specific Nanobody Tpp-3444 within 5.0Å range: probe atom residue distance (Å) B Occ A:Mn202 b:8.9 occ:1.00 O2 A:CIT201 2.1 11.0 1.0 O7 A:CIT201 2.1 10.4 1.0 O A:HOH360 2.1 11.9 1.0 O6 A:CIT201 2.1 11.5 1.0 NE2 A:HIS127 2.1 10.4 1.0 NE2 A:HIS129 2.1 11.8 1.0 HO7 A:CIT201 2.4 12.5 1.0 C6 A:CIT201 2.8 11.4 1.0 C3 A:CIT201 2.9 11.0 1.0 C1 A:CIT201 3.0 10.9 1.0 CE1 A:HIS127 3.1 9.2 1.0 CD2 A:HIS129 3.1 12.3 1.0 CE1 A:HIS129 3.1 12.7 1.0 CD2 A:HIS127 3.2 10.2 1.0 HE1 A:HIS127 3.2 11.1 1.0 HD2 A:HIS129 3.3 14.8 1.0 HE1 A:HIS129 3.3 15.3 1.0 HD2 A:HIS127 3.4 12.2 1.0 C2 A:CIT201 3.4 10.8 1.0 HE21 A:GLN13 3.5 13.2 1.0 HG2 A:GLN13 3.6 12.7 1.0 H22 A:CIT201 3.9 13.0 1.0 O A:HOH322 4.0 15.3 1.0 O5 A:CIT201 4.0 11.3 1.0 NE2 A:GLN13 4.1 11.0 1.0 O1 A:CIT201 4.1 10.9 1.0 ND1 A:HIS127 4.2 10.5 1.0 ND1 A:HIS129 4.2 14.2 1.0 O A:HOH440 4.2 23.1 1.0 CG A:HIS129 4.2 12.9 1.0 O A:LEU11 4.2 11.1 1.0 C4 A:CIT201 4.2 12.6 1.0 CG A:HIS127 4.3 10.8 1.0 O4 A:CIT201 4.3 13.4 1.0 H21 A:CIT201 4.4 13.0 1.0 HA A:VAL12 4.4 16.0 0.5 CG A:GLN13 4.4 10.6 1.0 HA A:VAL12 4.5 10.4 0.5 HG A:LEU11 4.5 13.8 1.0 O A:HOH500 4.5 21.7 1.0 HG3 A:GLN13 4.6 12.7 1.0 HE22 A:GLN13 4.6 13.2 1.0 H A:GLN13 4.6 12.8 1.0 H41 A:CIT201 4.7 15.1 1.0 HD23 A:LEU11 4.7 14.9 1.0 CD A:GLN13 4.7 10.8 1.0 C5 A:CIT201 4.7 13.0 1.0 O A:HOH375 4.8 14.3 1.0 HB3 A:LEU11 4.9 14.2 1.0 H42 A:CIT201 5.0 15.1 1.0 HD1 A:HIS127 5.0 12.6 1.0 HD1 A:HIS129 5.0 17.0 1.0 C A:LEU11 5.0 10.0 1.0

S.Jindal, D.V.Pedersen, N.Gera, J.Chandler, R.Patel, A.Neill, J.Cone, Y.Zhang, C.X.Yuan, E.E.Millman, D.Carlin, B.Puffer, D.Sheridan, G.R.Andersen, P.Tamburini. Characterization of the Bispecific Vhh Antibody Gefurulimab (ALXN1720) Targeting Complement Component 5, and Designed For Low Volume Subcutaneous Administration. Mol.Immunol. V. 165 29 2023.
ISSN: ISSN 0161-5890
PubMed: 38142486
DOI: 10.1016/J.MOLIMM.2023.12.004