Manganese in PDB 7yzk: Structure of Mycobacterium Tuberculosis Adenylyl Cyclase RV1625C / Cya

All present enzymatic activity of Structure of Mycobacterium Tuberculosis Adenylyl Cyclase RV1625C / Cya:
4.6.1.1;

The binding sites of Manganese atom in the Structure of Mycobacterium Tuberculosis Adenylyl Cyclase RV1625C / Cya (pdb code 7yzk). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total 4 binding sites of Manganese where determined in the Structure of Mycobacterium Tuberculosis Adenylyl Cyclase RV1625C / Cya, PDB code: 7yzk:
Jump to Manganese binding site number: 1; 2; 3; 4;

Manganese binding site 1 out of 4 in the Structure of Mycobacterium Tuberculosis Adenylyl Cyclase RV1625C / Cya


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of Structure of Mycobacterium Tuberculosis Adenylyl Cyclase RV1625C / Cya within 5.0Å range: probe atom residue distance (Å) B Occ A:Mn502 b:53.8 occ:1.00 O3B A:ONM501 1.7 38.9 1.0 O A:ILE257 2.3 36.3 1.0 OD2 A:ASP256 2.3 36.8 1.0 OD2 A:ASP300 2.5 33.9 1.0 O2G A:ONM501 2.5 38.9 1.0 PB A:ONM501 2.7 38.9 1.0 PG A:ONM501 2.8 38.9 0.5 O1B A:ONM501 2.8 38.9 1.0 O3G A:ONM501 2.8 38.9 1.0 C A:ILE257 3.4 36.3 1.0 O1A A:ONM501 3.5 38.9 1.0 CG A:ASP256 3.5 36.8 1.0 HH21 A:ARG344 3.5 37.6 1.0 CG A:ASP300 3.7 33.9 1.0 H A:ILE257 3.7 36.3 1.0 H5'1 A:ONM501 3.8 36.5 1.0 MN A:MN503 3.8 63.7 1.0 HA A:VAL258 3.9 38.8 1.0 HB A:ILE257 3.9 36.3 1.0 HH22 A:ARG344 3.9 37.6 1.0 NH2 A:ARG344 3.9 37.6 1.0 O2B A:ONM501 3.9 38.9 1.0 O2A A:ONM501 4.0 38.9 1.0 HB2 A:ASP300 4.1 33.9 1.0 N A:ILE257 4.1 36.3 1.0 OD1 A:ASP256 4.1 36.8 1.0 H A:PHE260 4.2 37.9 1.0 HB3 A:PHE260 4.2 37.9 1.0 HB2 A:PHE260 4.2 37.9 1.0 CA A:ILE257 4.2 36.3 1.0 O1G A:ONM501 4.3 38.9 1.0 CB A:ASP300 4.3 33.9 1.0 N A:VAL258 4.4 38.8 1.0 PA A:ONM501 4.4 38.9 1.0 HB3 A:ASP300 4.4 33.9 1.0 HB3 A:ASP256 4.5 36.8 1.0 CA A:VAL258 4.5 38.8 1.0 CB A:ILE257 4.6 36.3 1.0 H A:GLY259 4.6 42.5 1.0 C5' A:ONM501 4.6 38.9 1.0 CB A:ASP256 4.7 36.8 1.0 OD1 A:ASP300 4.7 33.9 1.0 CB A:PHE260 4.7 37.9 1.0 H5'2 A:ONM501 4.7 36.5 1.0 CZ A:ARG344 4.9 37.6 1.0 C A:ASP256 5.0 36.8 1.0 N A:GLY259 5.0 42.5 1.0 N A:PHE260 5.0 37.9 1.0

Manganese binding site 2 out of 4 in the Structure of Mycobacterium Tuberculosis Adenylyl Cyclase RV1625C / Cya


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 2 of Structure of Mycobacterium Tuberculosis Adenylyl Cyclase RV1625C / Cya within 5.0Å range: probe atom residue distance (Å) B Occ A:Mn503 b:63.7 occ:0.99 O2A A:ONM501 1.9 38.9 1.0 OD2 A:ASP300 2.2 33.9 1.0 OD1 A:ASP300 2.2 33.9 1.0 CG A:ASP300 2.4 33.9 1.0 OD1 A:ASP256 2.5 36.8 1.0 CG A:ASP256 3.2 36.8 1.0 OD2 A:ASP256 3.3 36.8 1.0 PA A:ONM501 3.3 38.9 1.0 H5'1 A:ONM501 3.8 36.5 1.0 MN A:MN502 3.8 53.8 1.0 O1A A:ONM501 3.9 38.9 1.0 HB2 A:SER301 3.9 31.5 1.0 CB A:ASP300 3.9 33.9 1.0 O3B A:ONM501 4.0 38.9 1.0 O3G A:ONM501 4.0 38.9 1.0 H A:SER301 4.0 31.5 1.0 O3A A:ONM501 4.1 38.9 1.0 H A:ASP300 4.2 33.9 1.0 HB2 A:ASP300 4.3 33.9 1.0 N A:SER301 4.3 31.5 1.0 O5' A:ONM501 4.4 38.9 1.0 HB3 A:ASP300 4.4 33.9 1.0 C5' A:ONM501 4.5 38.9 1.0 O4' A:ONM501 4.6 38.9 1.0 PB A:ONM501 4.6 38.9 1.0 CB A:SER301 4.6 31.5 1.0 HB3 A:SER301 4.6 31.5 1.0 H8 A:ONM501 4.7 36.5 1.0 CB A:ASP256 4.7 36.8 1.0 CA A:ASP300 4.7 33.9 1.0 N A:ASP300 4.7 33.9 1.0 C A:ASP300 4.8 33.9 1.0 HA A:SER301 4.8 31.5 1.0 HB2 A:ASP256 4.8 36.8 1.0 CA A:SER301 4.9 31.5 1.0 H A:ILE257 5.0 36.3 1.0

Manganese binding site 3 out of 4 in the Structure of Mycobacterium Tuberculosis Adenylyl Cyclase RV1625C / Cya


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 3 of Structure of Mycobacterium Tuberculosis Adenylyl Cyclase RV1625C / Cya within 5.0Å range: probe atom residue distance (Å) B Occ B:Mn502 b:53.5 occ:1.00 O3B B:ONM501 1.7 38.9 1.0 O B:ILE257 2.3 36.4 1.0 OD2 B:ASP256 2.3 37.0 1.0 OD2 B:ASP300 2.5 33.9 1.0 O2G B:ONM501 2.5 38.9 1.0 PB B:ONM501 2.7 38.9 1.0 PG B:ONM501 2.8 38.9 0.5 O1B B:ONM501 2.8 38.9 1.0 O3G B:ONM501 2.8 38.9 1.0 C B:ILE257 3.4 36.4 1.0 O1A B:ONM501 3.5 38.9 1.0 CG B:ASP256 3.5 37.0 1.0 HH21 B:ARG344 3.5 37.8 1.0 CG B:ASP300 3.7 33.9 1.0 H B:ILE257 3.7 36.4 1.0 H5'1 B:ONM501 3.8 36.6 1.0 MN B:MN503 3.8 64.9 1.0 HA B:VAL258 3.9 38.8 1.0 HB B:ILE257 3.9 36.4 1.0 HH22 B:ARG344 3.9 37.8 1.0 NH2 B:ARG344 3.9 37.8 1.0 O2B B:ONM501 3.9 38.9 1.0 O2A B:ONM501 4.0 38.9 1.0 HB2 B:ASP300 4.1 33.9 1.0 N B:ILE257 4.1 36.4 1.0 OD1 B:ASP256 4.1 37.0 1.0 H B:PHE260 4.2 37.9 1.0 HB3 B:PHE260 4.2 37.9 1.0 HB2 B:PHE260 4.2 37.9 1.0 CA B:ILE257 4.2 36.4 1.0 O1G B:ONM501 4.3 38.9 1.0 CB B:ASP300 4.3 33.9 1.0 N B:VAL258 4.4 38.8 1.0 PA B:ONM501 4.4 38.9 1.0 HB3 B:ASP300 4.4 33.9 1.0 HB3 B:ASP256 4.5 37.0 1.0 CA B:VAL258 4.5 38.8 1.0 CB B:ILE257 4.6 36.4 1.0 H B:GLY259 4.6 42.7 1.0 C5' B:ONM501 4.6 38.9 1.0 CB B:ASP256 4.7 37.0 1.0 OD1 B:ASP300 4.7 33.9 1.0 CB B:PHE260 4.7 37.9 1.0 H5'2 B:ONM501 4.7 36.6 1.0 CZ B:ARG344 4.9 37.8 1.0 C B:ASP256 5.0 37.0 1.0 N B:GLY259 5.0 42.7 1.0 N B:PHE260 5.0 37.9 1.0

Manganese binding site 4 out of 4 in the Structure of Mycobacterium Tuberculosis Adenylyl Cyclase RV1625C / Cya


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 4 of Structure of Mycobacterium Tuberculosis Adenylyl Cyclase RV1625C / Cya within 5.0Å range: probe atom residue distance (Å) B Occ B:Mn503 b:64.9 occ:0.99 O2A B:ONM501 1.9 38.9 1.0 OD2 B:ASP300 2.2 33.9 1.0 OD1 B:ASP300 2.2 33.9 1.0 CG B:ASP300 2.4 33.9 1.0 OD1 B:ASP256 2.5 37.0 1.0 CG B:ASP256 3.2 37.0 1.0 OD2 B:ASP256 3.3 37.0 1.0 PA B:ONM501 3.3 38.9 1.0 H5'1 B:ONM501 3.8 36.6 1.0 MN B:MN502 3.8 53.5 1.0 O1A B:ONM501 3.9 38.9 1.0 HB2 B:SER301 3.9 31.5 1.0 CB B:ASP300 3.9 33.9 1.0 O3B B:ONM501 4.0 38.9 1.0 O3G B:ONM501 4.0 38.9 1.0 H B:SER301 4.0 31.5 1.0 O3A B:ONM501 4.1 38.9 1.0 H B:ASP300 4.2 33.9 1.0 HB2 B:ASP300 4.3 33.9 1.0 N B:SER301 4.3 31.5 1.0 O5' B:ONM501 4.4 38.9 1.0 HB3 B:ASP300 4.4 33.9 1.0 C5' B:ONM501 4.5 38.9 1.0 O4' B:ONM501 4.6 38.9 1.0 PB B:ONM501 4.6 38.9 1.0 CB B:SER301 4.6 31.5 1.0 HB3 B:SER301 4.6 31.5 1.0 H8 B:ONM501 4.7 36.6 1.0 CB B:ASP256 4.7 37.0 1.0 CA B:ASP300 4.7 33.9 1.0 N B:ASP300 4.7 33.9 1.0 C B:ASP300 4.8 33.9 1.0 HA B:SER301 4.8 31.5 1.0 HB2 B:ASP256 4.8 37.0 1.0 CA B:SER301 4.9 31.5 1.0 H B:ILE257 5.0 36.4 1.0

V.Mehta, B.Khanppnavar, D.Schuster, I.Kantarci, I.Vercellino, A.Kosturanova, T.Iype, S.Stefanic, P.Picotti, V.M.Korkhov. Structure of Mycobacterium Tuberculosis Cya, An Evolutionary Ancestor of the Mammalian Membrane Adenylyl Cyclases. Elife V. 11 2022.
ISSN: ESSN 2050-084X
PubMed: 35980026
DOI: 10.7554/ELIFE.77032