Manganese in PDB 7yxu: Crystal Structure of Agonistic Antibody 1618 Fab Domain Bound to Human 4-1BB.

The structure of Crystal Structure of Agonistic Antibody 1618 Fab Domain Bound to Human 4-1BB., PDB code: 7yxu was solved by M.Hakansson, N.Rose, J.Petersson, K.Enell Smith, M.Thorolfsson, L.Vonschantz, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	41.56 / 2.31
Space group	P 21 21 2
Cell size a, b, c (Å), α, β, γ (°)	65.064, 213.465, 54.012, 90, 90, 90
R / Rfree (%)	20.5 / 25.2

The binding sites of Manganese atom in the Crystal Structure of Agonistic Antibody 1618 Fab Domain Bound to Human 4-1BB. (pdb code 7yxu). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total only one binding site of Manganese was determined in the Crystal Structure of Agonistic Antibody 1618 Fab Domain Bound to Human 4-1BB., PDB code: 7yxu:

Manganese binding site 1 out of 1 in the Crystal Structure of Agonistic Antibody 1618 Fab Domain Bound to Human 4-1BB.


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of Crystal Structure of Agonistic Antibody 1618 Fab Domain Bound to Human 4-1BB. within 5.0Å range: probe atom residue distance (Å) B Occ L:Mn301 b:46.4 occ:1.00 O H:HOH502 2.0 43.1 1.0 ND2 L:ASN137 2.1 35.5 1.0 OD1 L:ASN138 2.1 58.2 1.0 NE2 H:HIS172 2.2 43.6 1.0 CD2 H:HIS172 3.1 43.9 1.0 CG L:ASN137 3.1 49.6 1.0 CG L:ASN138 3.2 69.9 1.0 CE1 H:HIS172 3.3 43.2 1.0 OD1 L:ASN137 3.4 42.9 1.0 ND2 L:ASN138 3.7 66.1 1.0 OG L:SER174 4.1 45.6 1.0 OG1 H:THR191 4.1 44.5 1.0 CG H:HIS172 4.2 42.6 1.0 CB L:ASN138 4.3 47.1 1.0 ND1 H:HIS172 4.4 44.1 1.0 O H:GLY170 4.4 46.1 1.0 CB L:ASN137 4.4 36.5 1.0 N L:ASN138 4.5 45.1 1.0 O H:HOH595 4.7 56.9 1.0 CA H:GLY170 4.7 45.3 1.0 O L:HOH446 4.7 45.1 1.0 C H:GLY170 4.8 47.0 1.0 CA L:ASN138 4.9 46.0 1.0 CG2 H:THR191 4.9 42.3 1.0 CA L:ASN137 5.0 40.4 1.0

M.H.Nelson, S.Fritzell, R.Miller, D.Werchau, D.Van Citters, A.Nilsson, L.Misher, L.Ljung, R.Bader, A.Deronic, A.G.Chunyk, L.Schultz, L.A.Varas, N.Rose, M.Hakansson, J.Gross, C.Furebring, P.Pavlik, A.Sundstedt, N.Veitonmaki, H.J.Ramos, A.Sall, A.Dahlman, D.Bienvenue, L.Von Schantz, C.J.Mcmahan, M.Askmyr, G.Hernandez-Hoyos, P.Ellmark. The Bispecific Tumor Antigen-Conditional 4-1BB X 5T4 Agonist, Alg.Apv-527, Mediates Strong T-Cell Activation and Potent Antitumor Activity in Preclinical Studies. Mol.Cancer Ther. V. 22 89 2023.
ISSN: ESSN 1538-8514
PubMed: 36343381
DOI: 10.1158/1535-7163.MCT-22-0395