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Manganese in PDB 7utt: Structure of Non-Hydrolyzable Atp (Apcpp) Binds to Cyclic Gmp Amp Synthase (Cgas) Through Mn Coordination

Enzymatic activity of Structure of Non-Hydrolyzable Atp (Apcpp) Binds to Cyclic Gmp Amp Synthase (Cgas) Through Mn Coordination

All present enzymatic activity of Structure of Non-Hydrolyzable Atp (Apcpp) Binds to Cyclic Gmp Amp Synthase (Cgas) Through Mn Coordination:
2.7.7.86;

Protein crystallography data

The structure of Structure of Non-Hydrolyzable Atp (Apcpp) Binds to Cyclic Gmp Amp Synthase (Cgas) Through Mn Coordination, PDB code: 7utt was solved by S.Wu, S.B.Gabelli, J.Sohn, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 29.67 / 2.04
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 77.093, 97.882, 142.271, 90, 90, 90
R / Rfree (%) 18.1 / 21

Other elements in 7utt:

The structure of Structure of Non-Hydrolyzable Atp (Apcpp) Binds to Cyclic Gmp Amp Synthase (Cgas) Through Mn Coordination also contains other interesting chemical elements:

Zinc (Zn) 2 atoms

Manganese Binding Sites:

The binding sites of Manganese atom in the Structure of Non-Hydrolyzable Atp (Apcpp) Binds to Cyclic Gmp Amp Synthase (Cgas) Through Mn Coordination (pdb code 7utt). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total 4 binding sites of Manganese where determined in the Structure of Non-Hydrolyzable Atp (Apcpp) Binds to Cyclic Gmp Amp Synthase (Cgas) Through Mn Coordination, PDB code: 7utt:
Jump to Manganese binding site number: 1; 2; 3; 4;

Manganese binding site 1 out of 4 in 7utt

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Manganese binding site 1 out of 4 in the Structure of Non-Hydrolyzable Atp (Apcpp) Binds to Cyclic Gmp Amp Synthase (Cgas) Through Mn Coordination


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of Structure of Non-Hydrolyzable Atp (Apcpp) Binds to Cyclic Gmp Amp Synthase (Cgas) Through Mn Coordination within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mn603

b:28.6
occ:1.00
 OE2 A:GLU211 2.1 29.4 1.0
O A:HOH768 2.1 32.4 1.0
OD1 A:ASP213 2.1 27.6 1.0
O A:HOH732 2.2 25.1 1.0
O1A A:APC601 2.2 26.1 1.0
OD2 A:ASP307 2.3 29.4 1.0
CG A:ASP213 3.1 25.4 1.0
CD A:GLU211 3.1 29.5 1.0
CG A:ASP307 3.3 31.4 1.0
PA A:APC601 3.3 30.9 1.0
OE1 A:GLU211 3.5 27.5 1.0
OD2 A:ASP213 3.5 26.1 1.0
MN A:MN604 3.6 26.6 1.0
O2A A:APC601 3.6 30.5 1.0
O A:HOH794 3.8 49.9 1.0
CB A:ASP307 3.9 27.7 1.0
O5' A:APC601 4.0 27.3 1.0
O A:HOH776 4.2 42.9 1.0
OD1 A:ASP307 4.3 32.9 1.0
C5' A:APC601 4.3 27.6 1.0
CB A:ASP213 4.4 27.4 1.0
CG A:GLU211 4.5 29.2 1.0
C3A A:APC601 4.6 28.6 1.0
O3G A:APC601 4.8 27.8 1.0

Manganese binding site 2 out of 4 in 7utt

Go back to Manganese Binding Sites List in 7utt
Manganese binding site 2 out of 4 in the Structure of Non-Hydrolyzable Atp (Apcpp) Binds to Cyclic Gmp Amp Synthase (Cgas) Through Mn Coordination


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 2 of Structure of Non-Hydrolyzable Atp (Apcpp) Binds to Cyclic Gmp Amp Synthase (Cgas) Through Mn Coordination within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mn604

b:26.6
occ:1.00
 OE1 A:GLU211 2.2 27.5 1.0
OD2 A:ASP213 2.2 26.1 1.0
O3G A:APC601 2.2 27.8 1.0
O1B A:APC601 2.3 20.0 1.0
O1A A:APC601 2.3 26.1 1.0
O A:HOH717 2.3 24.8 1.0
CD A:GLU211 3.2 29.5 1.0
CG A:ASP213 3.2 25.4 1.0
C3A A:APC601 3.3 28.6 1.0
PB A:APC601 3.3 26.0 1.0
PA A:APC601 3.4 30.9 1.0
PG A:APC601 3.4 27.6 1.0
OE2 A:GLU211 3.5 29.4 1.0
OD1 A:ASP213 3.5 27.6 1.0
MN A:MN603 3.6 28.6 1.0
O3B A:APC601 3.7 27.8 1.0
O A:HOH794 3.7 49.9 1.0
OG A:SER199 3.9 26.2 1.0
C5' A:APC601 4.2 27.6 1.0
O A:HOH749 4.2 26.0 1.0
N A:SER199 4.2 25.3 1.0
O5' A:APC601 4.3 27.3 1.0
O A:GLU211 4.3 30.4 1.0
O1G A:APC601 4.3 28.0 1.0
CG A:GLU211 4.4 29.2 1.0
CB A:ASP213 4.5 27.4 1.0
O2G A:APC601 4.6 26.3 1.0
O2B A:APC601 4.6 23.4 1.0
O2A A:APC601 4.6 30.5 1.0
O A:HOH732 4.6 25.1 1.0
C A:GLU211 4.7 31.3 1.0
CB A:GLU211 4.7 33.0 1.0
CA A:GLY198 4.8 27.3 1.0
CB A:SER199 4.8 24.5 1.0
C A:GLY198 5.0 28.0 1.0
N A:ASP213 5.0 23.5 1.0
O A:HOH768 5.0 32.4 1.0

Manganese binding site 3 out of 4 in 7utt

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Manganese binding site 3 out of 4 in the Structure of Non-Hydrolyzable Atp (Apcpp) Binds to Cyclic Gmp Amp Synthase (Cgas) Through Mn Coordination


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 3 of Structure of Non-Hydrolyzable Atp (Apcpp) Binds to Cyclic Gmp Amp Synthase (Cgas) Through Mn Coordination within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Mn603

b:30.5
occ:1.00
 O C:HOH751 2.1 32.9 1.0
OE2 C:GLU211 2.1 30.5 1.0
OD2 C:ASP307 2.1 31.0 1.0
OD1 C:ASP213 2.2 27.7 1.0
O1A C:APC601 2.3 29.3 1.0
O C:HOH720 2.3 31.7 1.0
CD C:GLU211 3.1 33.4 1.0
CG C:ASP213 3.2 29.9 1.0
CG C:ASP307 3.2 34.2 1.0
PA C:APC601 3.4 31.4 1.0
OE1 C:GLU211 3.5 34.0 1.0
OD2 C:ASP213 3.6 30.1 1.0
MN C:MN604 3.6 28.1 1.0
O2A C:APC601 3.6 33.4 1.0
CB C:ASP307 3.8 31.5 1.0
O C:HOH762 3.9 42.3 1.0
O5' C:APC601 4.0 30.6 1.0
OD1 C:ASP307 4.3 34.1 1.0
C5' C:APC601 4.3 30.0 1.0
CB C:ASP213 4.5 28.4 1.0
CG C:GLU211 4.5 33.0 1.0
C3A C:APC601 4.7 31.1 1.0
O C:PHE212 4.9 31.5 1.0
O3G C:APC601 4.9 28.4 1.0

Manganese binding site 4 out of 4 in 7utt

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Manganese binding site 4 out of 4 in the Structure of Non-Hydrolyzable Atp (Apcpp) Binds to Cyclic Gmp Amp Synthase (Cgas) Through Mn Coordination


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 4 of Structure of Non-Hydrolyzable Atp (Apcpp) Binds to Cyclic Gmp Amp Synthase (Cgas) Through Mn Coordination within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Mn604

b:28.1
occ:1.00
 OE1 C:GLU211 2.1 34.0 1.0
OD2 C:ASP213 2.2 30.1 1.0
O3G C:APC601 2.2 28.4 1.0
O1A C:APC601 2.2 29.3 1.0
O1B C:APC601 2.2 27.0 1.0
O C:HOH706 2.4 23.4 1.0
CD C:GLU211 3.1 33.4 1.0
CG C:ASP213 3.2 29.9 1.0
C3A C:APC601 3.3 31.1 1.0
PB C:APC601 3.3 28.9 1.0
PA C:APC601 3.4 31.4 1.0
OE2 C:GLU211 3.5 30.5 1.0
OD1 C:ASP213 3.5 27.7 1.0
PG C:APC601 3.5 29.2 1.0
MN C:MN603 3.6 30.5 1.0
O3B C:APC601 3.8 27.6 1.0
OG C:SER199 4.0 26.7 1.0
C5' C:APC601 4.1 30.0 1.0
O5' C:APC601 4.2 30.6 1.0
N C:SER199 4.2 28.4 1.0
O C:GLU211 4.3 28.6 1.0
O C:HOH716 4.3 26.9 1.0
O1G C:APC601 4.4 25.5 1.0
CG C:GLU211 4.4 33.0 1.0
CB C:ASP213 4.5 28.4 1.0
O2A C:APC601 4.6 33.4 1.0
O2G C:APC601 4.6 29.8 1.0
O2B C:APC601 4.6 25.0 1.0
O C:HOH720 4.7 31.7 1.0
CB C:GLU211 4.7 31.0 1.0
C C:GLU211 4.7 30.2 1.0
CA C:GLY198 4.8 28.1 1.0
CB C:SER199 4.8 23.9 1.0
O C:HOH751 4.9 32.9 1.0
N C:ASP213 5.0 28.5 1.0
C C:GLY198 5.0 28.0 1.0

Reference:

S.Wu, S.B.Gabelli, J.S.Sohn. Structure of Non-Hydrolyzable Atp (Apcpp) Binds to Cyclic Gmp Amp Synthase (Cgas) Through Mn Coordination To Be Published.
Page generated: Sun Oct 6 10:57:04 2024

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