Manganese in PDB 7uqx: Cryo-Em Structure of the Human Exostosin-1 and Exostosin-2 Heterodimer in Complex with Udp-Glcnac

All present enzymatic activity of Cryo-Em Structure of the Human Exostosin-1 and Exostosin-2 Heterodimer in Complex with Udp-Glcnac:
2.4.1.224; 2.4.1.225;

The binding sites of Manganese atom in the Cryo-Em Structure of the Human Exostosin-1 and Exostosin-2 Heterodimer in Complex with Udp-Glcnac (pdb code 7uqx). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total only one binding site of Manganese was determined in the Cryo-Em Structure of the Human Exostosin-1 and Exostosin-2 Heterodimer in Complex with Udp-Glcnac, PDB code: 7uqx:

Manganese binding site 1 out of 1 in the Cryo-Em Structure of the Human Exostosin-1 and Exostosin-2 Heterodimer in Complex with Udp-Glcnac


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of Cryo-Em Structure of the Human Exostosin-1 and Exostosin-2 Heterodimer in Complex with Udp-Glcnac within 5.0Å range: probe atom residue distance (Å) B Occ B:Mn802 b:20.0 occ:1.00 O1A B:UDP801 1.8 73.0 1.0 O2B B:UDP801 2.6 73.0 1.0 PA B:UDP801 2.8 73.0 1.0 OD1 B:ASP540 2.8 75.2 1.0 O2A B:UDP801 3.1 73.0 1.0 CG B:ASP540 3.1 75.2 1.0 OD2 B:ASP540 3.4 75.2 1.0 O3A B:UDP801 3.7 73.0 1.0 PB B:UDP801 3.8 73.0 1.0 CB B:ASP540 4.0 75.2 1.0 O5' B:UDP801 4.1 73.0 1.0 O1B B:UDP801 4.8 73.0 1.0 O3B B:UDP801 4.8 73.0 1.0

H.Li, D.Chapla, R.A.Amos, A.Ramiah, K.W.Moremen, H.Li. Structural Basis For Heparan Sulfate Co-Polymerase Action By the EXT1-2 Complex Nat.Chem.Biol. 2022.
ISSN: ESSN 1552-4469