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Manganese in PDB 7u75: Human Dna Polymerase Eta-Dna Ternary Mismatch Complex:Reaction with 0.5 Mm MN2+ For 1800S Then with 10 Mm MN2+ For 90S
Enzymatic activity of Human Dna Polymerase Eta-Dna Ternary Mismatch Complex:Reaction with 0.5 Mm MN2+ For 1800S Then with 10 Mm MN2+ For 90S
All present enzymatic activity of Human Dna Polymerase Eta-Dna Ternary Mismatch Complex:Reaction with 0.5 Mm MN2+ For 1800S Then with 10 Mm MN2+ For 90S:
2.7.7.7;
2.7.7.7;
Protein crystallography data
The structure of Human Dna Polymerase Eta-Dna Ternary Mismatch Complex:Reaction with 0.5 Mm MN2+ For 1800S Then with 10 Mm MN2+ For 90S, PDB code: 7u75
was solved by
C.Chang,
Y.Gao,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 37.88 / 1.55 |
| Space group | P 61 |
| Cell size a, b, c (Å), α, β, γ (°) | 98.616, 98.616, 82.057, 90, 90, 120 |
| R / Rfree (%) | 18.7 / 22.2 |
Manganese Binding Sites:
The binding sites of Manganese atom in the Human Dna Polymerase Eta-Dna Ternary Mismatch Complex:Reaction with 0.5 Mm MN2+ For 1800S Then with 10 Mm MN2+ For 90S
(pdb code 7u75). This binding sites where shown within
5.0 Angstroms radius around Manganese atom.
In total 3 binding sites of Manganese where determined in the Human Dna Polymerase Eta-Dna Ternary Mismatch Complex:Reaction with 0.5 Mm MN2+ For 1800S Then with 10 Mm MN2+ For 90S, PDB code: 7u75:
Jump to Manganese binding site number: 1; 2; 3;
In total 3 binding sites of Manganese where determined in the Human Dna Polymerase Eta-Dna Ternary Mismatch Complex:Reaction with 0.5 Mm MN2+ For 1800S Then with 10 Mm MN2+ For 90S, PDB code: 7u75:
Jump to Manganese binding site number: 1; 2; 3;
Manganese binding site 1 out of 3 in 7u75
Go back to
Manganese Binding Sites List in 7u75
Manganese binding site 1 out
of 3 in the Human Dna Polymerase Eta-Dna Ternary Mismatch Complex:Reaction with 0.5 Mm MN2+ For 1800S Then with 10 Mm MN2+ For 90S
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Manganese with other atoms in the Mn binding
site number 1 of Human Dna Polymerase Eta-Dna Ternary Mismatch Complex:Reaction with 0.5 Mm MN2+ For 1800S Then with 10 Mm MN2+ For 90S within 5.0Å range:
|
Manganese binding site 2 out of 3 in 7u75
Go back to
Manganese Binding Sites List in 7u75
Manganese binding site 2 out
of 3 in the Human Dna Polymerase Eta-Dna Ternary Mismatch Complex:Reaction with 0.5 Mm MN2+ For 1800S Then with 10 Mm MN2+ For 90S
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Manganese with other atoms in the Mn binding
site number 2 of Human Dna Polymerase Eta-Dna Ternary Mismatch Complex:Reaction with 0.5 Mm MN2+ For 1800S Then with 10 Mm MN2+ For 90S within 5.0Å range:
|
Manganese binding site 3 out of 3 in 7u75
Go back to
Manganese Binding Sites List in 7u75
Manganese binding site 3 out
of 3 in the Human Dna Polymerase Eta-Dna Ternary Mismatch Complex:Reaction with 0.5 Mm MN2+ For 1800S Then with 10 Mm MN2+ For 90S
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Manganese with other atoms in the Mn binding
site number 3 of Human Dna Polymerase Eta-Dna Ternary Mismatch Complex:Reaction with 0.5 Mm MN2+ For 1800S Then with 10 Mm MN2+ For 90S within 5.0Å range:
|
Reference:
C.Chang,
C.Lee Luo,
Y.Gao.
In Crystallo Observation of Three Metal Ion Promoted Dna Polymerase Misincorporation. Nat Commun V. 13 2346 2022.
ISSN: ESSN 2041-1723
PubMed: 35487947
DOI: 10.1038/S41467-022-30005-3
Page generated: Sun Oct 6 10:41:38 2024
ISSN: ESSN 2041-1723
PubMed: 35487947
DOI: 10.1038/S41467-022-30005-3
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