Manganese in PDB 7sck: Cryo-Em Structure of the Human Exostosin-1 and Exostosin-2 Heterodimer in Complex with A 7-Sugar Oligosaccharide Acceptor Analog

Enzymatic activity of Cryo-Em Structure of the Human Exostosin-1 and Exostosin-2 Heterodimer in Complex with A 7-Sugar Oligosaccharide Acceptor Analog

All present enzymatic activity of Cryo-Em Structure of the Human Exostosin-1 and Exostosin-2 Heterodimer in Complex with A 7-Sugar Oligosaccharide Acceptor Analog:
2.4.1.224; 2.4.1.225;

Manganese Binding Sites:

The binding sites of Manganese atom in the Cryo-Em Structure of the Human Exostosin-1 and Exostosin-2 Heterodimer in Complex with A 7-Sugar Oligosaccharide Acceptor Analog (pdb code 7sck). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total only one binding site of Manganese was determined in the Cryo-Em Structure of the Human Exostosin-1 and Exostosin-2 Heterodimer in Complex with A 7-Sugar Oligosaccharide Acceptor Analog, PDB code: 7sck:

Manganese binding site 1 out of 1 in 7sck

Go back to Manganese Binding Sites List in 7sck
Manganese binding site 1 out of 1 in the Cryo-Em Structure of the Human Exostosin-1 and Exostosin-2 Heterodimer in Complex with A 7-Sugar Oligosaccharide Acceptor Analog


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of Cryo-Em Structure of the Human Exostosin-1 and Exostosin-2 Heterodimer in Complex with A 7-Sugar Oligosaccharide Acceptor Analog within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Mn902

b:50.2
occ:1.00
O2A B:UDP901 1.7 59.4 1.0
OD2 B:ASP540 2.5 55.7 1.0
PA B:UDP901 2.6 59.4 1.0
O1A B:UDP901 2.6 59.4 1.0
CG B:ASP540 3.5 55.7 1.0
O3A B:UDP901 3.6 59.4 1.0
OD1 B:ASP540 3.8 55.7 1.0
O5' B:UDP901 3.8 59.4 1.0
C5' B:UDP901 4.2 59.4 1.0
CD B:LYS653 4.4 65.1 1.0
O3B B:UDP901 4.4 59.4 1.0
NZ B:LYS653 4.6 65.1 1.0
PB B:UDP901 4.7 59.4 1.0
O3 D:BDP4 4.8 20.0 1.0
CB B:ASP540 4.8 55.7 1.0
NH2 B:ARG465 4.9 56.5 1.0
CE B:LYS653 4.9 65.1 1.0

Reference:

H.Li, D.Chapla, R.A.Amos, A.Ramiah, K.W.Moremen, H.Li. Structural Basis For Heparan Sulfate Co-Polymerase Action By the EXT1-2 Complex Nat.Chem.Biol. 2022.
ISSN: ESSN 1552-4469
Page generated: Fri Apr 7 12:22:12 2023

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