Atomistry » Manganese » PDB 7ohl-7sck » 7q5v
Atomistry »
  Manganese »
    PDB 7ohl-7sck »
      7q5v »

Manganese in PDB 7q5v: Hif Prolyl Hydroxylase 2 (PHD2/EGLN1) in Complex with N-Oxalylglycine (Nog) and Hif-2 Alpha Codd (523-542)

Enzymatic activity of Hif Prolyl Hydroxylase 2 (PHD2/EGLN1) in Complex with N-Oxalylglycine (Nog) and Hif-2 Alpha Codd (523-542)

All present enzymatic activity of Hif Prolyl Hydroxylase 2 (PHD2/EGLN1) in Complex with N-Oxalylglycine (Nog) and Hif-2 Alpha Codd (523-542):
1.14.11.29;

Protein crystallography data

The structure of Hif Prolyl Hydroxylase 2 (PHD2/EGLN1) in Complex with N-Oxalylglycine (Nog) and Hif-2 Alpha Codd (523-542), PDB code: 7q5v was solved by W.D.Figg Jr, M.A.Mcdonough, R.Chowdhury, Y.Nakashima, C.J.Schofield, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 42.88 / 1.17
Space group P 21 21 2
Cell size a, b, c (Å), α, β, γ (°) 130.914, 38.322, 42.88, 90, 90, 90
R / Rfree (%) 15.7 / 17.9

Other elements in 7q5v:

The structure of Hif Prolyl Hydroxylase 2 (PHD2/EGLN1) in Complex with N-Oxalylglycine (Nog) and Hif-2 Alpha Codd (523-542) also contains other interesting chemical elements:

Chlorine (Cl) 1 atom
Magnesium (Mg) 3 atoms

Manganese Binding Sites:

The binding sites of Manganese atom in the Hif Prolyl Hydroxylase 2 (PHD2/EGLN1) in Complex with N-Oxalylglycine (Nog) and Hif-2 Alpha Codd (523-542) (pdb code 7q5v). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total only one binding site of Manganese was determined in the Hif Prolyl Hydroxylase 2 (PHD2/EGLN1) in Complex with N-Oxalylglycine (Nog) and Hif-2 Alpha Codd (523-542), PDB code: 7q5v:

Manganese binding site 1 out of 1 in 7q5v

Go back to Manganese Binding Sites List in 7q5v
Manganese binding site 1 out of 1 in the Hif Prolyl Hydroxylase 2 (PHD2/EGLN1) in Complex with N-Oxalylglycine (Nog) and Hif-2 Alpha Codd (523-542)


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of Hif Prolyl Hydroxylase 2 (PHD2/EGLN1) in Complex with N-Oxalylglycine (Nog) and Hif-2 Alpha Codd (523-542) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mn501

b:9.3
occ:1.00
 OD1 A:ASP315 2.1 9.9 1.0
O1 A:OGA502 2.2 13.8 1.0
NE2 A:HIS374 2.2 9.8 1.0
O2' A:OGA502 2.2 12.5 1.0
NE2 A:HIS313 2.2 9.4 1.0
O A:HOH654 2.2 11.6 1.0
C2 A:OGA502 2.7 15.7 1.0
C1 A:OGA502 2.8 16.5 1.0
CE1 A:HIS313 3.0 9.5 1.0
CE1 A:HIS374 3.1 9.8 1.0
CG A:ASP315 3.2 9.4 1.0
HE1 A:HIS313 3.2 11.4 1.0
CD2 A:HIS374 3.2 9.7 1.0
CD2 A:HIS313 3.2 9.9 1.0
HE1 A:HIS374 3.3 11.7 1.0
HD2 A:HIS374 3.4 11.6 1.0
HG3 B:PRO531 3.4 14.1 1.0
HD2 A:HIS313 3.5 11.8 1.0
OD2 A:ASP315 3.5 10.1 1.0
N1 A:OGA502 4.0 17.4 1.0
HZ A:PHE366 4.0 13.3 1.0
O2 A:OGA502 4.0 17.5 1.0
HD3 B:PRO531 4.1 13.1 1.0
ND1 A:HIS313 4.2 10.7 1.0
HZ2 A:TRP389 4.2 13.7 1.0
ND1 A:HIS374 4.2 10.5 1.0
O A:HOH717 4.3 14.9 1.0
HA A:ASP315 4.3 11.8 1.0
CG B:PRO531 4.3 11.8 1.0
CG A:HIS374 4.3 10.1 1.0
CG A:HIS313 4.3 11.2 1.0
H4C2 A:OGA502 4.4 21.6 1.0
CB A:ASP315 4.5 10.0 1.0
C4 A:OGA502 4.6 18.0 1.0
HE2 A:TYR310 4.6 12.4 1.0
H4C1 A:OGA502 4.6 21.6 1.0
CD B:PRO531 4.6 10.9 1.0
H1 A:OGA502 4.7 20.9 1.0
CE2 A:TYR310 4.8 10.3 1.0
CA A:ASP315 4.8 9.8 1.0
HG2 B:PRO531 4.8 14.1 1.0
HG21 A:THR325 4.8 12.2 1.0
CZ A:PHE366 4.9 11.1 1.0
HD2 B:PRO531 4.9 13.1 1.0
HB3 B:PRO531 4.9 13.5 1.0
HE1 A:PHE366 4.9 13.5 1.0
HD1 A:HIS313 4.9 12.8 1.0
N A:ASP315 5.0 9.4 1.0
H A:ASP315 5.0 11.3 1.0

Reference:

W.D.Figg Jr, M.A.Mcdonough, R.Chowdhury, Y.Nakashima, C.J.Schofield. Hif Prolyl Hydroxylase 2 (PHD2/EGLN1) in Complex with N-Oxalylglycine (Nog) and Hif-2 Alpha Codd (523-542) To Be Published.
Page generated: Sun Oct 6 10:24:53 2024

Last articles

Zn in 9JYW
Zn in 9IR4
Zn in 9IR3
Zn in 9GMX
Zn in 9GMW
Zn in 9JEJ
Zn in 9ERF
Zn in 9ERE
Zn in 9EGV
Zn in 9EGW
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy