Manganese in PDB 7ojn: Lassa Virus L Protein in An Elongation Conformation [Elongation]

All present enzymatic activity of Lassa Virus L Protein in An Elongation Conformation [Elongation]:
2.7.7.48;

The structure of Lassa Virus L Protein in An Elongation Conformation [Elongation] also contains other interesting chemical elements:

Zinc

(Zn)

1 atom

The binding sites of Manganese atom in the Lassa Virus L Protein in An Elongation Conformation [Elongation] (pdb code 7ojn). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total 5 binding sites of Manganese where determined in the Lassa Virus L Protein in An Elongation Conformation [Elongation], PDB code: 7ojn:
Jump to Manganese binding site number: 1; 2; 3; 4; 5;

Manganese binding site 1 out of 5 in the Lassa Virus L Protein in An Elongation Conformation [Elongation]


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of Lassa Virus L Protein in An Elongation Conformation [Elongation] within 5.0Å range: probe atom residue distance (Å) B Occ L:Mn2302 b:14.2 occ:1.00 O2B L:2KH2301 1.9 30.7 1.0 OD2 L:ASP1190 2.0 22.5 1.0 O2G L:2KH2301 2.0 30.7 1.0 O L:HIS1191 2.2 31.2 1.0 O1A L:2KH2301 2.4 30.7 1.0 OD2 L:ASP1331 2.8 23.9 1.0 PB L:2KH2301 2.9 30.7 1.0 CG L:ASP1190 3.1 22.5 1.0 PG L:2KH2301 3.3 30.7 1.0 C L:HIS1191 3.4 31.2 1.0 PA L:2KH2301 3.4 30.7 1.0 N3A L:2KH2301 3.4 30.7 1.0 O3B L:2KH2301 3.4 30.7 1.0 OD1 L:ASP1190 3.5 22.5 1.0 N L:HIS1191 3.8 31.2 1.0 MN L:MN2303 3.8 31.2 1.0 CG L:ASP1331 4.0 23.9 1.0 CA L:HIS1191 4.2 31.2 1.0 O1G L:2KH2301 4.2 30.7 1.0 O1B L:2KH2301 4.2 30.7 1.0 O3G L:2KH2301 4.3 30.7 1.0 CB L:ASP1190 4.3 22.5 1.0 N L:SER1192 4.4 19.2 1.0 NZ L:LYS1373 4.4 16.5 1.0 C5' L:2KH2301 4.4 30.7 1.0 O2A L:2KH2301 4.5 30.7 1.0 OD1 L:ASP1331 4.5 23.9 1.0 O5' L:2KH2301 4.5 30.7 1.0 CA L:SER1192 4.6 19.2 1.0 N L:LYS1193 4.6 22.6 1.0 C L:ASP1190 4.7 22.5 1.0 CB L:HIS1191 4.8 31.2 1.0 C L:SER1192 4.9 19.2 1.0 N L:TRP1194 5.0 31.2 1.0 CA L:ASP1190 5.0 22.5 1.0

Manganese binding site 2 out of 5 in the Lassa Virus L Protein in An Elongation Conformation [Elongation]


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 2 of Lassa Virus L Protein in An Elongation Conformation [Elongation] within 5.0Å range: probe atom residue distance (Å) B Occ L:Mn2303 b:31.2 occ:1.00 OD1 L:ASP1332 2.1 21.1 1.0 OD1 L:ASP1190 2.1 22.5 1.0 O1A L:2KH2301 2.2 30.7 1.0 O3' M:G26 2.3 31.2 1.0 OD1 L:ASP1331 2.5 23.9 1.0 OD2 L:ASP1331 3.1 23.9 1.0 CG L:ASP1331 3.1 23.9 1.0 CG L:ASP1190 3.2 22.5 1.0 PA L:2KH2301 3.3 30.7 1.0 CG L:ASP1332 3.3 21.1 1.0 O2A L:2KH2301 3.5 30.7 1.0 OD2 L:ASP1190 3.6 22.5 1.0 C3' M:G26 3.6 31.2 1.0 MN L:MN2302 3.8 14.2 1.0 O5' L:2KH2301 3.8 30.7 1.0 OD2 L:ASP1332 4.0 21.1 1.0 C5' L:2KH2301 4.1 30.7 1.0 N L:ASP1332 4.2 21.1 1.0 C4' M:G26 4.3 31.2 1.0 CB L:ASP1332 4.5 21.1 1.0 CB L:ASP1190 4.5 22.5 1.0 C5' M:G26 4.5 31.2 1.0 CB L:ASP1331 4.6 23.9 1.0 O2' M:G26 4.6 31.2 1.0 CA L:ASP1332 4.7 21.1 1.0 C2' M:G26 4.7 31.2 1.0 C L:ASP1331 4.7 23.9 1.0 O2B L:2KH2301 4.7 30.7 1.0 N3A L:2KH2301 4.7 30.7 1.0

Manganese binding site 3 out of 5 in the Lassa Virus L Protein in An Elongation Conformation [Elongation]


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 3 of Lassa Virus L Protein in An Elongation Conformation [Elongation] within 5.0Å range: probe atom residue distance (Å) B Occ L:Mn2304 b:44.7 occ:1.00 OD1 L:ASP89 3.0 47.0 1.0 OE2 L:GLU188 3.0 138.3 1.0 MN L:MN2305 3.4 39.3 1.0 O L:VAL87 3.7 40.5 1.0 CG L:ASP89 3.9 47.0 1.0 CD L:GLU188 3.9 138.3 1.0 OD2 L:ASP89 4.1 47.0 1.0 CG L:GLU188 4.3 138.3 1.0 OD2 L:ASP1765 4.7 58.3 1.0 OE1 L:GLU188 4.9 138.3 1.0 C L:VAL87 4.9 40.5 1.0

Manganese binding site 4 out of 5 in the Lassa Virus L Protein in An Elongation Conformation [Elongation]


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 4 of Lassa Virus L Protein in An Elongation Conformation [Elongation] within 5.0Å range: probe atom residue distance (Å) B Occ L:Mn2305 b:39.3 occ:1.00 O L:CYS103 2.9 57.9 1.0 OD2 L:ASP89 3.0 47.0 1.0 MN L:MN2304 3.4 44.7 1.0 OE2 L:GLU188 3.5 138.3 1.0 OD1 L:ASP89 3.6 47.0 1.0 CD L:GLU188 3.7 138.3 1.0 CG L:ASP89 3.7 47.0 1.0 OE1 L:GLU188 3.8 138.3 1.0 C L:CYS103 4.0 57.9 1.0 N L:CYS103 4.4 57.9 1.0 OE1 L:GLU51 4.4 58.1 1.0 CG L:GLU188 4.5 138.3 1.0 CA L:CYS103 4.8 57.9 1.0 N L:PHE104 4.9 59.1 1.0 CB L:PHE104 4.9 59.1 1.0 CA L:PHE104 5.0 59.1 1.0

Manganese binding site 5 out of 5 in the Lassa Virus L Protein in An Elongation Conformation [Elongation]


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 5 of Lassa Virus L Protein in An Elongation Conformation [Elongation] within 5.0Å range: probe atom residue distance (Å) B Occ L:Mn2306 b:14.5 occ:1.00 OE1 L:GLU1152 2.4 17.4 1.0 CD L:GLU1152 3.3 17.4 1.0 OE2 L:GLU1152 3.6 17.4 1.0 OP1 R:G20 4.1 31.2 1.0 OD1 L:ASP1149 4.1 17.0 1.0 CG L:GLU1152 4.7 17.4 1.0 O3' R:U19 4.7 31.2 1.0 OD1 L:ASN1164 4.8 18.2 1.0 NH2 L:ARG1145 4.9 15.8 1.0

T.Kouba, D.Vogel, S.Thorkelsson, E.Quemin, H.William, M.Milewski, C.Busch, S.Gunther, K.Grunewald, M.Rosenthal, S.Cusack. Conformational Changes in Lassa Virus L Protein Associated with Promoter Binding and Rna Synthesis Activity To Be Published.