Manganese in PDB 7ne6: Human TET2 in Complex with Unfavourable Dna Substrate.

The structure of Human TET2 in Complex with Unfavourable Dna Substrate., PDB code: 7ne6 was solved by D.Rafalski, M.Bochtler, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	43.97 / 2.30
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	47.858, 87.943, 261.988, 90, 90, 90
R / Rfree (%)	19.5 / 22.7

The structure of Human TET2 in Complex with Unfavourable Dna Substrate. also contains other interesting chemical elements:

Zinc

(Zn)

3 atoms

The binding sites of Manganese atom in the Human TET2 in Complex with Unfavourable Dna Substrate. (pdb code 7ne6). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total only one binding site of Manganese was determined in the Human TET2 in Complex with Unfavourable Dna Substrate., PDB code: 7ne6:

Manganese binding site 1 out of 1 in the Human TET2 in Complex with Unfavourable Dna Substrate.


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of Human TET2 in Complex with Unfavourable Dna Substrate. within 5.0Å range: probe atom residue distance (Å) B Occ A:Mn2007 b:29.4 occ:1.00 O2' A:OGA2004 2.1 39.6 1.0 NE2 A:HIS1382 2.4 34.5 1.0 NE2 A:HIS1881 2.4 34.6 1.0 O1 A:OGA2004 2.5 45.2 1.0 O A:HOH2189 2.6 41.5 1.0 OD2 A:ASP1384 2.6 41.2 1.0 OD1 A:ASP1384 2.8 42.6 1.0 C2 A:OGA2004 2.9 38.9 1.0 CG A:ASP1384 3.0 41.0 1.0 C1 A:OGA2004 3.1 42.7 1.0 CE1 A:HIS1382 3.1 34.9 1.0 CD2 A:HIS1881 3.2 33.7 1.0 CD2 A:HIS1382 3.4 35.2 1.0 CE1 A:HIS1881 3.4 35.0 1.0 O A:HOH2158 4.1 35.1 1.0 ND1 A:HIS1382 4.2 35.9 1.0 NH2 A:ARG1261 4.2 40.5 1.0 N1 A:OGA2004 4.3 36.8 1.0 O2 A:OGA2004 4.3 45.0 1.0 CG A:HIS1382 4.4 36.2 1.0 CG A:HIS1881 4.4 34.9 1.0 O A:HOH2105 4.4 39.9 1.0 ND1 A:HIS1881 4.4 35.9 1.0 CB A:ASP1384 4.4 38.2 1.0 CB A:ALA1876 4.6 32.3 1.0 C4 A:OGA2004 4.8 34.1 1.0 C5A B:5CM6 4.9 33.2 1.0 N A:ASP1384 4.9 35.5 1.0

M.Ravichandran, D.Rafalski, C.I.Davies, O.Ortega-Recalde, X.Nan, C.R.Glanfield, A.Kotter, K.Misztal, A.H.Wang, M.Wojciechowski, M.Razew, I.M.Mayyas, O.Kardailsky, U.Schwartz, K.Zembrzycki, I.M.Morison, M.Helm, D.Weichenhan, R.Z.Jurkowska, F.Krueger, C.Plass, M.Zacharias, M.Bochtler, T.A.Hore, T.P.Jurkowski. Pronounced Sequence Specificity of the Tet Enzyme Catalytic Domain Guides Its Cellular Function. Sci Adv V. 8 M2427 2022.
ISSN: ESSN 2375-2548
PubMed: 36070377
DOI: 10.1126/SCIADV.ABM2427