Manganese in PDB 7n7g: Crystal Structure of Fosb From Enterococcus Faecium with Fosfomycin

The structure of Crystal Structure of Fosb From Enterococcus Faecium with Fosfomycin, PDB code: 7n7g was solved by M.R.Shay, Z.Simmons, M.K.Thompson, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	23.80 / 2.00
Space group	P 41 21 2
Cell size a, b, c (Å), α, β, γ (°)	79.874, 79.874, 95.639, 90, 90, 90
R / Rfree (%)	21.4 / 25.4

The binding sites of Manganese atom in the Crystal Structure of Fosb From Enterococcus Faecium with Fosfomycin (pdb code 7n7g). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total 2 binding sites of Manganese where determined in the Crystal Structure of Fosb From Enterococcus Faecium with Fosfomycin, PDB code: 7n7g:
Jump to Manganese binding site number: 1; 2;

Manganese binding site 1 out of 2 in the Crystal Structure of Fosb From Enterococcus Faecium with Fosfomycin


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of Crystal Structure of Fosb From Enterococcus Faecium with Fosfomycin within 5.0Å range: probe atom residue distance (Å) B Occ A:Mn201 b:31.3 occ:1.00 OE1 A:GLU115 2.0 20.4 1.0 O2P A:FCN207 2.1 39.5 1.0 NE2 B:HIS7 2.2 22.3 1.0 O A:FCN207 2.3 35.5 1.0 NE2 A:HIS66 2.3 21.4 1.0 CD A:GLU115 3.0 22.8 1.0 CE1 B:HIS7 3.1 24.1 1.0 P A:FCN207 3.2 46.6 1.0 C1 A:FCN207 3.2 44.5 1.0 CE1 A:HIS66 3.2 21.7 1.0 CD2 B:HIS7 3.2 22.5 1.0 CD2 A:HIS66 3.3 24.4 1.0 OE2 A:GLU115 3.5 22.0 1.0 C2 A:FCN207 3.7 43.0 1.0 O1P A:FCN207 3.9 43.0 1.0 OH A:TYR105 4.0 28.8 1.0 OG1 B:THR9 4.0 21.1 1.0 CE2 A:TYR105 4.0 29.1 1.0 C3 A:FCN207 4.2 40.3 1.0 ND1 B:HIS7 4.2 23.9 1.0 CG A:GLU115 4.3 22.3 1.0 CG B:HIS7 4.3 23.4 1.0 ND1 A:HIS66 4.4 21.3 1.0 CB A:ALA68 4.4 18.5 1.0 O3P A:FCN207 4.4 42.7 1.0 CG A:HIS66 4.4 22.8 1.0 CZ A:TYR105 4.5 31.6 1.0 CB A:GLU115 4.5 21.6 1.0 CB B:THR9 4.9 22.6 1.0

Manganese binding site 2 out of 2 in the Crystal Structure of Fosb From Enterococcus Faecium with Fosfomycin


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 2 of Crystal Structure of Fosb From Enterococcus Faecium with Fosfomycin within 5.0Å range: probe atom residue distance (Å) B Occ B:Mn201 b:36.6 occ:1.00 O B:FCN203 2.0 64.0 1.0 OE1 B:GLU115 2.0 27.9 1.0 NE2 A:HIS7 2.1 23.1 1.0 NE2 B:HIS66 2.2 24.0 1.0 O3P B:FCN203 2.3 50.9 1.0 C1 B:FCN203 2.9 56.4 1.0 CD B:GLU115 3.0 31.3 1.0 CE1 A:HIS7 3.1 22.7 1.0 CE1 B:HIS66 3.1 23.6 1.0 P B:FCN203 3.1 59.4 1.0 CD2 A:HIS7 3.2 22.2 1.0 CD2 B:HIS66 3.2 25.8 1.0 C2 B:FCN203 3.4 63.7 1.0 OE2 B:GLU115 3.4 29.2 1.0 O1P B:FCN203 3.8 48.0 1.0 OH B:TYR105 4.1 31.9 1.0 OG1 A:THR9 4.1 24.5 1.0 ND1 A:HIS7 4.2 21.9 1.0 CE1 B:TYR105 4.2 32.2 1.0 ND1 B:HIS66 4.2 25.9 1.0 CG A:HIS7 4.3 21.2 1.0 CG B:HIS66 4.3 27.5 1.0 CB B:ALA68 4.3 22.7 1.0 C3 B:FCN203 4.3 59.6 1.0 O2P B:FCN203 4.4 51.2 1.0 CG B:GLU115 4.4 29.6 1.0 CB B:GLU115 4.6 30.9 1.0 CZ B:TYR105 4.7 31.3 1.0 CB A:THR9 4.9 23.7 1.0 OH B:TYR64 4.9 46.7 1.0

V.Wiltsie, S.Travis, M.R.Shay, Z.Simmons, P.Frantom, M.K.Thompson. Structural and Functional Characterization of Fosfomycin Resistance Conferred By Fosb From Enterococcus Faecium. Protein Sci. V. 31 580 2022.
ISSN: ESSN 1469-896X
PubMed: 34882867
DOI: 10.1002/PRO.4253