Manganese in PDB 7elb: Structure of Machupo Virus L Polymerase in Complex with Z Protein (Dimeric Form)

All present enzymatic activity of Structure of Machupo Virus L Polymerase in Complex with Z Protein (Dimeric Form):
2.7.7.48;

The structure of Structure of Machupo Virus L Polymerase in Complex with Z Protein (Dimeric Form) also contains other interesting chemical elements:

Zinc

(Zn)

8 atoms

The binding sites of Manganese atom in the Structure of Machupo Virus L Polymerase in Complex with Z Protein (Dimeric Form) (pdb code 7elb). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total 2 binding sites of Manganese where determined in the Structure of Machupo Virus L Polymerase in Complex with Z Protein (Dimeric Form), PDB code: 7elb:
Jump to Manganese binding site number: 1; 2;

Manganese binding site 1 out of 2 in the Structure of Machupo Virus L Polymerase in Complex with Z Protein (Dimeric Form)


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of Structure of Machupo Virus L Polymerase in Complex with Z Protein (Dimeric Form) within 5.0Å range: probe atom residue distance (Å) B Occ A:Mn2301 b:185.4 occ:1.00 OD2 A:ASP1330 2.0 117.7 1.0 OD1 A:ASP1188 2.7 117.5 1.0 OE1 A:GLU1381 2.9 88.0 1.0 CG A:ASP1330 3.0 117.7 1.0 CB A:ASP1330 3.4 117.7 1.0 OE2 A:GLU1381 3.4 88.0 1.0 CD A:GLU1381 3.5 88.0 1.0 CG A:ASP1188 3.6 117.5 1.0 OD2 A:ASP1188 3.7 117.5 1.0 OD1 A:ASP1330 4.2 117.7 1.0 N A:LYS1383 4.3 85.4 1.0 CA A:PHE1382 4.7 92.7 1.0 CA A:ASP1330 4.9 117.7 1.0 O A:GLU1381 4.9 88.0 1.0 CB A:ASP1188 5.0 117.5 1.0

Manganese binding site 2 out of 2 in the Structure of Machupo Virus L Polymerase in Complex with Z Protein (Dimeric Form)


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 2 of Structure of Machupo Virus L Polymerase in Complex with Z Protein (Dimeric Form) within 5.0Å range: probe atom residue distance (Å) B Occ C:Mn2301 b:183.8 occ:1.00 OD2 C:ASP1330 2.0 116.5 1.0 OD1 C:ASP1188 2.7 117.9 1.0 OE1 C:GLU1381 2.9 88.9 1.0 CG C:ASP1330 3.0 116.5 1.0 CB C:ASP1330 3.4 116.5 1.0 OE2 C:GLU1381 3.4 88.9 1.0 CD C:GLU1381 3.5 88.9 1.0 CG C:ASP1188 3.6 117.9 1.0 OD2 C:ASP1188 3.7 117.9 1.0 OD1 C:ASP1330 4.2 116.5 1.0 N C:LYS1383 4.3 85.2 1.0 CA C:PHE1382 4.7 92.1 1.0 CA C:ASP1330 4.9 116.5 1.0 O C:GLU1381 4.9 88.9 1.0 CB C:ASP1188 5.0 117.9 1.0

R.Peng, X.Xu, Q.Peng, Y.Shi. Cryo-Em Structures of Lassa and Machupo Virus Polymerases Complexed with Cognate Regulatory Z Proteins Identify Targets For Antivirals. Nat Microbiol 2021.
ISSN: ESSN 2058-5276