Manganese in PDB 7ela: Structure of Lassa Virus Polymerase in Complex with 3'-Vrna and Z Mutant (F36A)

All present enzymatic activity of Structure of Lassa Virus Polymerase in Complex with 3'-Vrna and Z Mutant (F36A):
2.7.7.48;

The structure of Structure of Lassa Virus Polymerase in Complex with 3'-Vrna and Z Mutant (F36A) also contains other interesting chemical elements:

Zinc

(Zn)

2 atoms

The binding sites of Manganese atom in the Structure of Lassa Virus Polymerase in Complex with 3'-Vrna and Z Mutant (F36A) (pdb code 7ela). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total only one binding site of Manganese was determined in the Structure of Lassa Virus Polymerase in Complex with 3'-Vrna and Z Mutant (F36A), PDB code: 7ela:

Manganese binding site 1 out of 1 in the Structure of Lassa Virus Polymerase in Complex with 3'-Vrna and Z Mutant (F36A)


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of Structure of Lassa Virus Polymerase in Complex with 3'-Vrna and Z Mutant (F36A) within 5.0Å range: probe atom residue distance (Å) B Occ A:Mn2400 b:31.1 occ:1.00 OE1 A:GLU1384 2.4 35.9 1.0 OD1 A:ASP1192 2.6 30.7 1.0 CD A:GLU1384 3.1 35.9 1.0 CB A:ASP1334 3.1 31.7 1.0 OE2 A:GLU1384 3.2 35.9 1.0 OD1 A:ASP1334 3.4 31.7 1.0 CG A:ASP1334 3.5 31.7 1.0 O A:MET1191 3.7 35.9 1.0 CG A:ASP1192 3.7 30.7 1.0 O A:GLU1384 3.8 35.9 1.0 OD2 A:ASP1192 4.2 30.7 1.0 O A:GLN1335 4.2 35.9 1.0 CA A:PHE1385 4.2 35.9 1.0 CA A:ASP1334 4.3 31.7 1.0 C A:GLU1384 4.4 35.9 1.0 N A:GLN1335 4.4 35.9 1.0 OD2 A:ASP1334 4.4 31.7 1.0 C A:MET1191 4.5 35.9 1.0 N A:LYS1386 4.5 35.9 1.0 CG A:GLU1384 4.5 35.9 1.0 C A:ASP1334 4.5 31.7 1.0 N A:PHE1385 4.6 35.9 1.0 CD1 A:PHE1385 4.7 35.9 1.0 C A:PHE1385 4.9 35.9 1.0 N A:MET1191 4.9 35.9 1.0 C A:GLN1335 4.9 35.9 1.0 CB A:GLU1384 5.0 35.9 1.0 N A:ASP1192 5.0 30.7 1.0

R.Peng, X.Xu, Q.Peng, Y.Shi. Cryo-Em Structures of Lassa and Machupo Virus Polymerases Complexed with Cognate Regulatory Z Proteins Identify Targets For Antivirals. Nat Microbiol 2021.
ISSN: ESSN 2058-5276