Manganese »
PDB 6zbn-7bm0 »
7a14 »
Manganese in PDB 7a14: Crystal Structure of Human Methionine Aminopeptidase-2 in Complex with An Inhibitor GSK2218325A (Compound 32)
Enzymatic activity of Crystal Structure of Human Methionine Aminopeptidase-2 in Complex with An Inhibitor GSK2218325A (Compound 32)
All present enzymatic activity of Crystal Structure of Human Methionine Aminopeptidase-2 in Complex with An Inhibitor GSK2218325A (Compound 32):
3.4.11.18;
3.4.11.18;
Protein crystallography data
The structure of Crystal Structure of Human Methionine Aminopeptidase-2 in Complex with An Inhibitor GSK2218325A (Compound 32), PDB code: 7a14
was solved by
J.H.Thorpe,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 29.90 / 2.14 |
| Space group | C 2 2 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 87.343, 100.812, 99.047, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 17.9 / 21.5 |
Other elements in 7a14:
The structure of Crystal Structure of Human Methionine Aminopeptidase-2 in Complex with An Inhibitor GSK2218325A (Compound 32) also contains other interesting chemical elements:
| Fluorine | (F) | 1 atom |
| Chlorine | (Cl) | 1 atom |
Manganese Binding Sites:
The binding sites of Manganese atom in the Crystal Structure of Human Methionine Aminopeptidase-2 in Complex with An Inhibitor GSK2218325A (Compound 32)
(pdb code 7a14). This binding sites where shown within
5.0 Angstroms radius around Manganese atom.
In total 2 binding sites of Manganese where determined in the Crystal Structure of Human Methionine Aminopeptidase-2 in Complex with An Inhibitor GSK2218325A (Compound 32), PDB code: 7a14:
Jump to Manganese binding site number: 1; 2;
In total 2 binding sites of Manganese where determined in the Crystal Structure of Human Methionine Aminopeptidase-2 in Complex with An Inhibitor GSK2218325A (Compound 32), PDB code: 7a14:
Jump to Manganese binding site number: 1; 2;
Manganese binding site 1 out of 2 in 7a14
Go back to
Manganese Binding Sites List in 7a14
Manganese binding site 1 out
of 2 in the Crystal Structure of Human Methionine Aminopeptidase-2 in Complex with An Inhibitor GSK2218325A (Compound 32)
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Manganese with other atoms in the Mn binding
site number 1 of Crystal Structure of Human Methionine Aminopeptidase-2 in Complex with An Inhibitor GSK2218325A (Compound 32) within 5.0Å range:
|
Manganese binding site 2 out of 2 in 7a14
Go back to
Manganese Binding Sites List in 7a14
Manganese binding site 2 out
of 2 in the Crystal Structure of Human Methionine Aminopeptidase-2 in Complex with An Inhibitor GSK2218325A (Compound 32)
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Manganese with other atoms in the Mn binding
site number 2 of Crystal Structure of Human Methionine Aminopeptidase-2 in Complex with An Inhibitor GSK2218325A (Compound 32) within 5.0Å range:
|
Reference:
D.J.Hirst,
M.Brandt,
G.Bruton,
E.Christodoulou,
L.Cutler,
N.Deeks,
J.D.Goodacre,
T.Jack,
M.Lindon,
A.Miah,
K.Page,
N.Parr,
L.Shukla,
M.Sims,
P.Thomas,
J.Thorpe,
D.S.Holmes.
Structure-Based Optimisation of Orally Active & Reversible Metap-2 Inhibitors Maintaining A Tight 'Molecular Budget'. Bioorg.Med.Chem.Lett. V. 30 27533 2020.
ISSN: ESSN 1464-3405
PubMed: 32919012
DOI: 10.1016/J.BMCL.2020.127533
Page generated: Sun Oct 6 08:02:34 2024
ISSN: ESSN 1464-3405
PubMed: 32919012
DOI: 10.1016/J.BMCL.2020.127533
Last articles
Zn in 9JPJZn in 9JP7
Zn in 9JPK
Zn in 9JPL
Zn in 9GN6
Zn in 9GN7
Zn in 9GKU
Zn in 9GKW
Zn in 9GKX
Zn in 9GL0
