Manganese in PDB 7a14: Crystal Structure of Human Methionine Aminopeptidase-2 in Complex with An Inhibitor GSK2218325A (Compound 32)
Enzymatic activity of Crystal Structure of Human Methionine Aminopeptidase-2 in Complex with An Inhibitor GSK2218325A (Compound 32)
All present enzymatic activity of Crystal Structure of Human Methionine Aminopeptidase-2 in Complex with An Inhibitor GSK2218325A (Compound 32):
3.4.11.18;
3.4.11.18;
Protein crystallography data
The structure of Crystal Structure of Human Methionine Aminopeptidase-2 in Complex with An Inhibitor GSK2218325A (Compound 32), PDB code: 7a14
was solved by
J.H.Thorpe,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 29.90 / 2.14 |
| Space group | C 2 2 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 87.343, 100.812, 99.047, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 17.9 / 21.5 |
Other elements in 7a14:
The structure of Crystal Structure of Human Methionine Aminopeptidase-2 in Complex with An Inhibitor GSK2218325A (Compound 32) also contains other interesting chemical elements:
| Fluorine | (F) | 1 atom |
| Chlorine | (Cl) | 1 atom |
Manganese Binding Sites:
The binding sites of Manganese atom in the Crystal Structure of Human Methionine Aminopeptidase-2 in Complex with An Inhibitor GSK2218325A (Compound 32)
(pdb code 7a14). This binding sites where shown within
5.0 Angstroms radius around Manganese atom.
In total 2 binding sites of Manganese where determined in the Crystal Structure of Human Methionine Aminopeptidase-2 in Complex with An Inhibitor GSK2218325A (Compound 32), PDB code: 7a14:
Jump to Manganese binding site number: 1; 2;
In total 2 binding sites of Manganese where determined in the Crystal Structure of Human Methionine Aminopeptidase-2 in Complex with An Inhibitor GSK2218325A (Compound 32), PDB code: 7a14:
Jump to Manganese binding site number: 1; 2;
Manganese binding site 1 out of 2 in 7a14
Go back to
Manganese Binding Sites List in 7a14
Manganese binding site 1 out
of 2 in the Crystal Structure of Human Methionine Aminopeptidase-2 in Complex with An Inhibitor GSK2218325A (Compound 32)
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Manganese with other atoms in the Mn binding
site number 1 of Crystal Structure of Human Methionine Aminopeptidase-2 in Complex with An Inhibitor GSK2218325A (Compound 32) within 5.0Å range:
|
Manganese binding site 2 out of 2 in 7a14
Go back to
Manganese Binding Sites List in 7a14
Manganese binding site 2 out
of 2 in the Crystal Structure of Human Methionine Aminopeptidase-2 in Complex with An Inhibitor GSK2218325A (Compound 32)
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Manganese with other atoms in the Mn binding
site number 2 of Crystal Structure of Human Methionine Aminopeptidase-2 in Complex with An Inhibitor GSK2218325A (Compound 32) within 5.0Å range:
|
Reference:
D.J.Hirst,
M.Brandt,
G.Bruton,
E.Christodoulou,
L.Cutler,
N.Deeks,
J.D.Goodacre,
T.Jack,
M.Lindon,
A.Miah,
K.Page,
N.Parr,
L.Shukla,
M.Sims,
P.Thomas,
J.Thorpe,
D.S.Holmes.
Structure-Based Optimisation of Orally Active & Reversible Metap-2 Inhibitors Maintaining A Tight 'Molecular Budget'. Bioorg.Med.Chem.Lett. V. 30 27533 2020.
ISSN: ESSN 1464-3405
PubMed: 32919012
DOI: 10.1016/J.BMCL.2020.127533
Page generated: Tue Dec 15 05:11:36 2020
ISSN: ESSN 1464-3405
PubMed: 32919012
DOI: 10.1016/J.BMCL.2020.127533
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