Atomistry » Manganese » PDB 6wj4-6z6r » 6yyu
Atomistry »
  Manganese »
    PDB 6wj4-6z6r »
      6yyu »

Manganese in PDB 6yyu: Aspartyl/Asparaginyl Beta-Hydroxylase (Asph) Oxygenase and Tpr Domains in Complex with Manganese and 2-Oxoglutarate

Enzymatic activity of Aspartyl/Asparaginyl Beta-Hydroxylase (Asph) Oxygenase and Tpr Domains in Complex with Manganese and 2-Oxoglutarate

All present enzymatic activity of Aspartyl/Asparaginyl Beta-Hydroxylase (Asph) Oxygenase and Tpr Domains in Complex with Manganese and 2-Oxoglutarate:
1.14.11.16;

Protein crystallography data

The structure of Aspartyl/Asparaginyl Beta-Hydroxylase (Asph) Oxygenase and Tpr Domains in Complex with Manganese and 2-Oxoglutarate, PDB code: 6yyu was solved by Y.Nakashima, L.Brewitz, C.J.Schofield, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 85.44 / 2.11
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 48.791, 70.003, 170.87, 90, 90, 90
R / Rfree (%) 20.2 / 23.1

Manganese Binding Sites:

The binding sites of Manganese atom in the Aspartyl/Asparaginyl Beta-Hydroxylase (Asph) Oxygenase and Tpr Domains in Complex with Manganese and 2-Oxoglutarate (pdb code 6yyu). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total only one binding site of Manganese was determined in the Aspartyl/Asparaginyl Beta-Hydroxylase (Asph) Oxygenase and Tpr Domains in Complex with Manganese and 2-Oxoglutarate, PDB code: 6yyu:

Manganese binding site 1 out of 1 in 6yyu

Go back to Manganese Binding Sites List in 6yyu
Manganese binding site 1 out of 1 in the Aspartyl/Asparaginyl Beta-Hydroxylase (Asph) Oxygenase and Tpr Domains in Complex with Manganese and 2-Oxoglutarate


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of Aspartyl/Asparaginyl Beta-Hydroxylase (Asph) Oxygenase and Tpr Domains in Complex with Manganese and 2-Oxoglutarate within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mn801

b:35.2
occ:1.00
 O1 A:AKG802 1.6 72.0 1.0
NE2 A:HIS725 2.1 36.9 1.0
O A:HOH905 2.1 34.2 1.0
NE2 A:HIS679 2.3 44.2 1.0
C1 A:AKG802 2.3 66.7 1.0
O A:HOH937 2.4 48.9 1.0
O5 A:AKG802 2.5 70.2 1.0
C2 A:AKG802 2.8 57.6 1.0
CE1 A:HIS679 3.0 42.1 1.0
HE1 A:HIS679 3.0 61.0 1.0
CD2 A:HIS725 3.1 37.7 1.0
CE1 A:HIS725 3.1 31.7 1.0
HD2 A:HIS725 3.2 58.3 1.0
HE1 A:HIS725 3.3 45.9 1.0
CD2 A:HIS679 3.4 31.6 1.0
O2 A:AKG802 3.5 28.4 1.0
HH11 A:ARG688 3.5 44.6 1.0
HD2 A:HIS679 3.7 37.9 1.0
HH12 A:ARG688 3.8 44.6 1.0
NH1 A:ARG688 4.0 30.5 1.0
ND1 A:HIS679 4.2 34.6 1.0
ND1 A:HIS725 4.2 37.8 1.0
HB2 A:ASP721 4.2 42.6 1.0
CG A:HIS725 4.2 28.4 1.0
C3 A:AKG802 4.3 52.6 1.0
CG A:HIS679 4.4 32.8 1.0
OD2 A:ASP721 4.6 31.0 1.0
H32 A:AKG802 4.6 63.2 1.0
HD13 A:LEU619 4.6 83.1 1.0
H31 A:AKG802 4.8 63.2 1.0
HZ A:PHE719 4.8 37.2 1.0
HD2 A:ARG688 4.9 66.0 1.0
HD1 A:HIS679 4.9 43.6 1.0
HE2 A:PHE719 5.0 50.8 1.0
H42 A:AKG802 5.0 64.5 1.0
HH2 A:TRP625 5.0 80.5 1.0
HD1 A:HIS725 5.0 58.0 1.0

Reference:

L.Brewitz, Y.Nakashima, C.J.Schofield. Synthesis of 2-Oxoglutarate Derivatives and Their Evaluation As Cosubstrates and Inhibitors of Human Aspartate/Asparagine-Beta-Hydroxylase Chem Sci V. 12 1327 2021.
ISSN: ESSN 2041-6539
DOI: 10.1039/D0SC04301J
Page generated: Sun Oct 6 07:56:10 2024

Last articles

Zn in 9JPJ
Zn in 9JP7
Zn in 9JPK
Zn in 9JPL
Zn in 9GN6
Zn in 9GN7
Zn in 9GKU
Zn in 9GKW
Zn in 9GKX
Zn in 9GL0
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy