Manganese in PDB 6w5x: Crystal Structure of Human Polymerase Eta Complexed with N7- Benzylguanine and Dctp*

All present enzymatic activity of Crystal Structure of Human Polymerase Eta Complexed with N7- Benzylguanine and Dctp*:
2.7.7.7;

The structure of Crystal Structure of Human Polymerase Eta Complexed with N7- Benzylguanine and Dctp*, PDB code: 6w5x was solved by H.Jung, S.Lee, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	49.16 / 2.59
Space group	P 61
Cell size a, b, c (Å), α, β, γ (°)	98.329, 98.329, 81.312, 90, 90, 120
R / Rfree (%)	18.4 / 25.6

The structure of Crystal Structure of Human Polymerase Eta Complexed with N7- Benzylguanine and Dctp* also contains other interesting chemical elements:

Fluorine

(F)

1 atom

The binding sites of Manganese atom in the Crystal Structure of Human Polymerase Eta Complexed with N7- Benzylguanine and Dctp* (pdb code 6w5x). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total 2 binding sites of Manganese where determined in the Crystal Structure of Human Polymerase Eta Complexed with N7- Benzylguanine and Dctp*, PDB code: 6w5x:
Jump to Manganese binding site number: 1; 2;

Manganese binding site 1 out of 2 in the Crystal Structure of Human Polymerase Eta Complexed with N7- Benzylguanine and Dctp*


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of Crystal Structure of Human Polymerase Eta Complexed with N7- Benzylguanine and Dctp* within 5.0Å range: probe atom residue distance (Å) B Occ A:Mn503 b:40.0 occ:1.00 OE1 A:GLU116 2.0 44.8 1.0 O A:HOH609 2.1 39.1 1.0 OD2 A:ASP13 2.1 37.2 1.0 OD1 A:ASP115 2.3 47.3 1.0 O2A A:0KX502 2.3 38.9 1.0 O3' P:DG8 2.4 44.9 1.0 OD2 A:ASP115 2.8 43.4 1.0 CG A:ASP115 2.9 44.0 1.0 C3' P:DG8 3.0 45.2 1.0 CD A:GLU116 3.1 40.4 1.0 CG A:ASP13 3.2 37.4 1.0 PA A:0KX502 3.3 38.5 1.0 O1A A:0KX502 3.5 44.8 1.0 MN A:MN504 3.6 39.7 1.0 OD1 A:ASP13 3.7 41.9 1.0 OE2 A:GLU116 3.7 40.4 1.0 O5' A:0KX502 3.8 40.1 1.0 OG A:SER113 3.8 38.1 1.0 C4' P:DG8 3.8 46.9 1.0 C5' A:0KX502 4.1 39.6 1.0 CG A:GLU116 4.1 40.3 1.0 O A:HOH611 4.2 38.9 1.0 CB A:GLU116 4.2 39.2 1.0 C2' P:DG8 4.3 49.9 1.0 CB A:ASP115 4.4 39.7 1.0 C5' P:DG8 4.4 51.6 1.0 CB A:ASP13 4.5 37.0 1.0 C A:ASP115 4.6 45.7 1.0 O A:ASP115 4.6 45.9 1.0 O3G A:0KX502 4.8 38.3 1.0 CB A:SER113 4.8 37.4 1.0 N3A A:0KX502 4.8 42.7 1.0 O1B A:0KX502 4.8 39.1 1.0 N A:GLU116 4.8 44.1 1.0 CA A:ASP115 4.9 42.6 1.0

Manganese binding site 2 out of 2 in the Crystal Structure of Human Polymerase Eta Complexed with N7- Benzylguanine and Dctp*


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 2 of Crystal Structure of Human Polymerase Eta Complexed with N7- Benzylguanine and Dctp* within 5.0Å range: probe atom residue distance (Å) B Occ A:Mn504 b:39.7 occ:1.00 O2A A:0KX502 2.0 38.9 1.0 O1B A:0KX502 2.0 39.1 1.0 OD2 A:ASP115 2.1 43.4 1.0 OD1 A:ASP13 2.1 41.9 1.0 O A:MET14 2.2 37.4 1.0 O3G A:0KX502 2.2 38.3 1.0 PB A:0KX502 3.0 41.2 1.0 CG A:ASP13 3.1 37.4 1.0 PA A:0KX502 3.3 38.5 1.0 OD2 A:ASP13 3.3 37.2 1.0 C A:MET14 3.3 39.5 1.0 CG A:ASP115 3.4 44.0 1.0 PG A:0KX502 3.4 40.6 1.0 N3A A:0KX502 3.5 42.7 1.0 O3B A:0KX502 3.5 37.9 1.0 MN A:MN503 3.6 40.0 1.0 NZ A:LYS231 3.8 40.1 1.0 N A:MET14 3.8 41.9 1.0 C5' A:0KX502 3.9 39.6 1.0 O1G A:0KX502 4.0 39.6 1.0 O5' A:0KX502 4.1 40.1 1.0 O A:HOH611 4.1 38.9 1.0 OD1 A:ASP115 4.1 47.3 1.0 CA A:MET14 4.1 39.9 1.0 C A:ASP13 4.3 38.5 1.0 CB A:ASP13 4.4 37.0 1.0 CB A:ASP115 4.4 39.7 1.0 O A:HOH609 4.4 39.1 1.0 O2B A:0KX502 4.4 42.2 1.0 N A:ASP15 4.4 42.3 1.0 O1A A:0KX502 4.4 44.8 1.0 N A:CYS16 4.4 40.7 1.0 O2G A:0KX502 4.6 42.5 1.0 CB A:MET14 4.6 38.9 1.0 N A:PHE17 4.6 38.9 1.0 CE A:LYS231 4.6 43.9 1.0 CA A:ASP15 4.6 42.2 1.0 C A:ASP15 4.7 40.0 1.0 O A:ASP13 4.8 45.0 1.0 CB A:PHE17 4.8 35.2 1.0 CA A:ASP13 4.8 36.9 1.0 O A:ASP115 4.9 45.9 1.0

H.Jung, S.Lee. Crystal Structure of Human Polymerase Eta Complexed with N7-Benzylguanine and Dctp* To Be Published.