Atomistry » Manganese » PDB 6qv9-6ru4 » 6r5e
Atomistry »
  Manganese »
    PDB 6qv9-6ru4 »
      6r5e »

Manganese in PDB 6r5e: Crystal Structure of the PRI1 Subunit of Human Primase Bound to 2F-Atp

Protein crystallography data

The structure of Crystal Structure of the PRI1 Subunit of Human Primase Bound to 2F-Atp, PDB code: 6r5e was solved by M.L.Kilkenny, L.Pellegrini, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 46.41 / 1.85
Space group C 2 2 21
Cell size a, b, c (Å), α, β, γ (°) 110.500, 117.180, 152.090, 90.00, 90.00, 90.00
R / Rfree (%) 17.8 / 20.6

Other elements in 6r5e:

The structure of Crystal Structure of the PRI1 Subunit of Human Primase Bound to 2F-Atp also contains other interesting chemical elements:

Fluorine (F) 2 atoms
Zinc (Zn) 2 atoms

Manganese Binding Sites:

The binding sites of Manganese atom in the Crystal Structure of the PRI1 Subunit of Human Primase Bound to 2F-Atp (pdb code 6r5e). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total 4 binding sites of Manganese where determined in the Crystal Structure of the PRI1 Subunit of Human Primase Bound to 2F-Atp, PDB code: 6r5e:
Jump to Manganese binding site number: 1; 2; 3; 4;

Manganese binding site 1 out of 4 in 6r5e

Go back to Manganese Binding Sites List in 6r5e
Manganese binding site 1 out of 4 in the Crystal Structure of the PRI1 Subunit of Human Primase Bound to 2F-Atp


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of Crystal Structure of the PRI1 Subunit of Human Primase Bound to 2F-Atp within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mn502

b:29.5
occ:1.00
O2B A:JSQ504 2.0 35.6 1.0
OD1 A:ASP111 2.1 40.9 1.0
O A:HOH674 2.2 33.0 1.0
OD1 A:ASP109 2.2 35.3 1.0
O2A A:JSQ504 2.3 32.4 1.0
O2G A:JSQ504 2.3 32.3 1.0
CG A:ASP109 3.0 35.2 1.0
CG A:ASP111 3.1 36.3 1.0
OD2 A:ASP109 3.2 45.9 1.0
PB A:JSQ504 3.2 36.0 1.0
PA A:JSQ504 3.5 40.0 1.0
OD2 A:ASP111 3.5 38.1 1.0
PG A:JSQ504 3.5 32.7 1.0
HE A:ARG163 3.5 55.0 1.0
MN A:MN503 3.6 40.6 1.0
H5'2 A:JSQ504 3.6 63.4 1.0
O3A A:JSQ504 3.6 38.6 1.0
O3B A:JSQ504 3.7 34.7 1.0
HH21 A:ARG163 3.8 58.9 1.0
NE2 A:HIS166 3.9 29.1 1.0
O3G A:JSQ504 4.1 34.5 1.0
HB2 A:SER160 4.2 36.7 1.0
HG3 A:ARG163 4.2 54.7 1.0
O A:ILE110 4.2 30.5 1.0
NE A:ARG163 4.3 45.8 1.0
HD2 A:HIS166 4.3 35.2 1.0
HA A:ASP111 4.3 36.3 1.0
HB3 A:SER160 4.4 36.7 1.0
C5' A:JSQ504 4.4 52.8 1.0
O5' A:JSQ504 4.5 45.5 1.0
O1B A:JSQ504 4.5 31.7 1.0
OG A:SER160 4.5 32.6 1.0
CB A:ASP111 4.5 33.5 1.0
NH2 A:ARG163 4.5 49.0 1.0
O1A A:JSQ504 4.5 42.2 1.0
CD2 A:HIS166 4.5 29.3 1.0
CB A:ASP109 4.5 29.9 1.0
CB A:SER160 4.6 30.6 1.0
H5'1 A:JSQ504 4.6 63.4 1.0
C A:ILE110 4.7 32.8 1.0
O1G A:JSQ504 4.7 35.7 1.0
HB2 A:ASP109 4.8 35.9 1.0
HB3 A:ASP111 4.8 40.1 1.0
CA A:ASP111 4.8 30.3 1.0
HG A:SER160 4.8 39.1 1.0
H A:ILE110 4.8 36.7 1.0
CZ A:ARG163 4.8 48.7 1.0
CG A:ARG163 4.9 45.5 1.0
HG2 A:ARG163 4.9 54.7 1.0
N A:ILE110 4.9 30.6 1.0
HA A:ASP109 5.0 34.0 1.0
N A:ASP111 5.0 31.6 1.0

Manganese binding site 2 out of 4 in 6r5e

Go back to Manganese Binding Sites List in 6r5e
Manganese binding site 2 out of 4 in the Crystal Structure of the PRI1 Subunit of Human Primase Bound to 2F-Atp


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 2 of Crystal Structure of the PRI1 Subunit of Human Primase Bound to 2F-Atp within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mn503

b:40.6
occ:1.00
OD2 A:ASP109 2.2 45.9 1.0
OD2 A:ASP306 2.2 54.6 1.0
OD2 A:ASP111 2.2 38.1 1.0
O2A A:JSQ504 2.4 32.4 1.0
O A:HOH756 2.5 46.0 1.0
O A:HOH686 2.5 51.9 1.0
CG A:ASP111 3.2 36.3 1.0
CG A:ASP109 3.3 35.2 1.0
CG A:ASP306 3.3 50.8 1.0
H5'1 A:JSQ504 3.4 63.4 1.0
HH21 A:ARG163 3.5 58.9 1.0
PA A:JSQ504 3.5 40.0 1.0
OD1 A:ASP111 3.5 40.9 1.0
HB2 A:ASP306 3.6 57.1 1.0
MN A:MN502 3.6 29.5 1.0
O5' A:JSQ504 3.7 45.5 1.0
OD1 A:ASP109 3.8 35.3 1.0
CB A:ASP306 3.8 47.6 1.0
HB3 A:ASP306 3.9 57.1 1.0
HG21 A:VAL309 3.9 59.1 1.0
NH2 A:ARG163 3.9 49.0 1.0
C5' A:JSQ504 3.9 52.8 1.0
HH22 A:ARG163 4.0 58.9 1.0
O A:HOH665 4.0 51.0 1.0
O1A A:JSQ504 4.0 42.2 1.0
O A:HOH670 4.0 62.5 1.0
H5'2 A:JSQ504 4.0 63.4 1.0
O A:HOH680 4.1 45.3 1.0
HB3 A:ASP109 4.4 35.9 1.0
OD1 A:ASP306 4.4 53.2 1.0
CB A:ASP109 4.5 29.9 1.0
CB A:ASP111 4.6 33.5 1.0
HG23 A:VAL309 4.6 59.1 1.0
CG2 A:VAL309 4.6 49.2 1.0
HB2 A:ASP111 4.6 40.1 1.0
O2B A:JSQ504 4.7 35.6 1.0
HG22 A:VAL309 4.8 59.1 1.0
O3A A:JSQ504 4.9 38.6 1.0
CZ A:ARG163 4.9 48.7 1.0
O2G A:JSQ504 5.0 32.3 1.0
HE A:ARG163 5.0 55.0 1.0
HB3 A:ASP111 5.0 40.1 1.0

Manganese binding site 3 out of 4 in 6r5e

Go back to Manganese Binding Sites List in 6r5e
Manganese binding site 3 out of 4 in the Crystal Structure of the PRI1 Subunit of Human Primase Bound to 2F-Atp


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 3 of Crystal Structure of the PRI1 Subunit of Human Primase Bound to 2F-Atp within 5.0Å range:
probe atom residue distance (Å) B Occ
E:Mn502

b:38.5
occ:1.00
OD1 E:ASP111 2.1 51.4 1.0
O2B E:JSQ504 2.1 36.3 1.0
O E:HOH685 2.2 34.6 1.0
OD1 E:ASP109 2.2 43.9 1.0
O2A E:JSQ504 2.3 39.0 1.0
O2G E:JSQ504 2.3 36.5 1.0
CG E:ASP109 3.1 37.0 1.0
CG E:ASP111 3.2 45.6 1.0
PB E:JSQ504 3.2 36.8 1.0
OD2 E:ASP109 3.2 47.7 1.0
PA E:JSQ504 3.5 43.4 1.0
PG E:JSQ504 3.5 37.5 1.0
O3A E:JSQ504 3.6 40.8 1.0
HE E:ARG163 3.6 61.1 1.0
OD2 E:ASP111 3.6 48.7 1.0
O3B E:JSQ504 3.6 37.6 1.0
MN E:MN503 3.6 43.7 1.0
H5'1 E:JSQ504 3.7 64.7 1.0
HH21 E:ARG163 3.7 67.3 1.0
NE2 E:HIS166 3.9 32.6 1.0
O3G E:JSQ504 4.1 36.4 1.0
HB2 E:SER160 4.1 37.4 1.0
HD2 E:HIS166 4.2 39.1 1.0
HA E:ASP111 4.3 38.8 1.0
NE E:ARG163 4.3 50.9 1.0
HB3 E:SER160 4.3 37.4 1.0
HG3 E:ARG163 4.3 58.9 1.0
O E:ILE110 4.4 30.3 1.0
NH2 E:ARG163 4.4 56.1 1.0
C5' E:JSQ504 4.4 53.9 1.0
CD2 E:HIS166 4.4 32.5 1.0
H5'2 E:JSQ504 4.4 64.7 1.0
O5' E:JSQ504 4.4 47.3 1.0
CB E:ASP111 4.5 38.7 1.0
O1A E:JSQ504 4.5 46.1 1.0
CB E:ASP109 4.5 31.0 1.0
O1B E:JSQ504 4.5 35.1 1.0
CB E:SER160 4.5 31.2 1.0
OG E:SER160 4.6 36.3 1.0
C E:ILE110 4.7 30.7 1.0
O1G E:JSQ504 4.7 38.6 1.0
CA E:ASP111 4.8 32.3 1.0
CZ E:ARG163 4.8 53.4 1.0
HB2 E:ASP109 4.8 37.2 1.0
HB3 E:ASP111 4.8 46.4 1.0
H E:ILE110 4.8 33.7 1.0
HA3 E:GLY164 4.9 37.5 1.0
N E:ILE110 4.9 28.1 1.0
N E:ASP111 4.9 30.5 1.0
HA E:ASP109 5.0 33.8 1.0
HG E:SER160 5.0 43.6 1.0
HH22 E:ARG163 5.0 67.3 1.0
CE1 E:HIS166 5.0 32.9 1.0

Manganese binding site 4 out of 4 in 6r5e

Go back to Manganese Binding Sites List in 6r5e
Manganese binding site 4 out of 4 in the Crystal Structure of the PRI1 Subunit of Human Primase Bound to 2F-Atp


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 4 of Crystal Structure of the PRI1 Subunit of Human Primase Bound to 2F-Atp within 5.0Å range:
probe atom residue distance (Å) B Occ
E:Mn503

b:43.7
occ:1.00
OD2 E:ASP109 2.2 47.7 1.0
OD2 E:ASP306 2.2 54.3 1.0
OD2 E:ASP111 2.2 48.7 1.0
O2A E:JSQ504 2.4 39.0 1.0
O E:HOH751 2.5 53.1 1.0
O E:HOH745 3.0 51.0 1.0
CG E:ASP111 3.2 45.6 1.0
CG E:ASP306 3.3 49.8 1.0
CG E:ASP109 3.3 37.0 1.0
HB2 E:ASP306 3.5 53.5 1.0
H5'2 E:JSQ504 3.5 64.7 1.0
PA E:JSQ504 3.5 43.4 1.0
OD1 E:ASP111 3.5 51.4 1.0
MN E:MN502 3.6 38.5 1.0
O5' E:JSQ504 3.7 47.3 1.0
HH21 E:ARG163 3.7 67.3 1.0
CB E:ASP306 3.7 44.6 1.0
HB3 E:ASP306 3.8 53.5 1.0
OD1 E:ASP109 3.8 43.9 1.0
O E:HOH694 3.8 50.0 1.0
HH22 E:ARG163 4.0 67.3 1.0
O1A E:JSQ504 4.0 46.1 1.0
HG21 E:VAL309 4.0 57.0 1.0
C5' E:JSQ504 4.0 53.9 1.0
NH2 E:ARG163 4.0 56.1 1.0
O E:HOH733 4.0 46.9 1.0
H5'1 E:JSQ504 4.3 64.7 1.0
OD1 E:ASP306 4.3 52.4 1.0
HB3 E:ASP109 4.4 37.2 1.0
CB E:ASP109 4.5 31.0 1.0
CB E:ASP111 4.6 38.7 1.0
HG23 E:VAL309 4.6 57.0 1.0
HB2 E:ASP111 4.6 46.4 1.0
CG2 E:VAL309 4.7 47.5 1.0
HG22 E:VAL309 4.8 57.0 1.0
O3A E:JSQ504 4.8 40.8 1.0
O2B E:JSQ504 4.9 36.3 1.0
CZ E:ARG163 4.9 53.4 1.0
O2G E:JSQ504 5.0 36.5 1.0
O E:ASP109 5.0 33.6 1.0

Reference:

S.Holzer, N.J.Rzechorzek, I.R.Short, M.Jenkyn-Bedford, L.Pellegrini, M.L.Kilkenny. Structural Basis For Inhibition of Human Primase By Arabinofuranosyl Nucleoside Analogues Fludarabine and Vidarabine. Acs Chem.Biol. V. 14 1904 2019.
ISSN: ESSN 1554-8937
PubMed: 31479243
DOI: 10.1021/ACSCHEMBIO.9B00367
Page generated: Sun Oct 6 06:59:48 2024

Last articles

Fe in 2YXO
Fe in 2YRS
Fe in 2YXC
Fe in 2YNM
Fe in 2YVJ
Fe in 2YP1
Fe in 2YU2
Fe in 2YU1
Fe in 2YQB
Fe in 2YOO
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy