Atomistry » Manganese » PDB 6oe2-6q9f » 6p1o
Atomistry »
  Manganese »
    PDB 6oe2-6q9f »
      6p1o »

Manganese in PDB 6p1o: Post-Catalytic Nicked Complex of Human Dna Polymerase Mu with 1-Nt Gapped Substrate Containing Template 8OG and Newly Incorporated Damp

Enzymatic activity of Post-Catalytic Nicked Complex of Human Dna Polymerase Mu with 1-Nt Gapped Substrate Containing Template 8OG and Newly Incorporated Damp

All present enzymatic activity of Post-Catalytic Nicked Complex of Human Dna Polymerase Mu with 1-Nt Gapped Substrate Containing Template 8OG and Newly Incorporated Damp:
2.7.7.7;

Protein crystallography data

The structure of Post-Catalytic Nicked Complex of Human Dna Polymerase Mu with 1-Nt Gapped Substrate Containing Template 8OG and Newly Incorporated Damp, PDB code: 6p1o was solved by A.M.Kaminski, L.C.Pedersen, K.Bebenek, K.K.Chiruvella, D.A.Ramsden, T.A.Kunkel, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 25.15 / 1.65
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 59.947, 68.713, 110.724, 90.00, 90.00, 90.00
R / Rfree (%) 16.7 / 18.7

Other elements in 6p1o:

The structure of Post-Catalytic Nicked Complex of Human Dna Polymerase Mu with 1-Nt Gapped Substrate Containing Template 8OG and Newly Incorporated Damp also contains other interesting chemical elements:

Magnesium (Mg) 1 atom
Chlorine (Cl) 3 atoms
Sodium (Na) 1 atom

Manganese Binding Sites:

The binding sites of Manganese atom in the Post-Catalytic Nicked Complex of Human Dna Polymerase Mu with 1-Nt Gapped Substrate Containing Template 8OG and Newly Incorporated Damp (pdb code 6p1o). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total only one binding site of Manganese was determined in the Post-Catalytic Nicked Complex of Human Dna Polymerase Mu with 1-Nt Gapped Substrate Containing Template 8OG and Newly Incorporated Damp, PDB code: 6p1o:

Manganese binding site 1 out of 1 in 6p1o

Go back to Manganese Binding Sites List in 6p1o
Manganese binding site 1 out of 1 in the Post-Catalytic Nicked Complex of Human Dna Polymerase Mu with 1-Nt Gapped Substrate Containing Template 8OG and Newly Incorporated Damp


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of Post-Catalytic Nicked Complex of Human Dna Polymerase Mu with 1-Nt Gapped Substrate Containing Template 8OG and Newly Incorporated Damp within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mn501

b:14.9
occ:0.73
 OD1 A:ASP332 1.8 18.6 1.0
OD2 A:ASP330 1.8 22.4 1.0
OD2 A:ASP418 2.0 19.9 1.0
OP1 P:DA5 2.1 21.1 1.0
CG A:ASP330 2.8 24.4 1.0
CG A:ASP332 2.8 17.4 1.0
O3' P:DA4 3.0 24.5 1.0
CG A:ASP418 3.0 19.2 1.0
OD1 A:ASP330 3.0 18.2 1.0
P P:DA5 3.1 21.6 1.0
OD2 A:ASP332 3.2 17.3 1.0
MG A:MG502 3.4 19.6 1.0
CB A:ASP418 3.6 16.3 1.0
OD1 A:ASP418 4.0 19.5 1.0
C3' P:DA4 4.2 22.2 1.0
CB A:ASP332 4.2 13.7 1.0
CB A:ASP330 4.2 19.7 1.0
O5' P:DA5 4.2 16.1 1.0
OP2 P:DA5 4.2 21.6 1.0
C5' P:DA5 4.2 16.2 1.0
C4' P:DA4 4.2 20.1 1.0
C5' P:DA4 4.3 20.1 1.0
CE1 A:HIS329 4.5 26.1 0.5
O A:VAL331 4.6 16.5 1.0
NH2 A:ARG416 4.6 21.0 1.0
CA A:ASP332 4.7 14.1 1.0
O32 A:PPV507 4.7 35.2 0.6
CZ3 A:TRP434 4.7 22.1 1.0
N A:ASP418 4.7 17.0 1.0
C A:VAL331 4.8 15.6 1.0
O2B P:ATP701 4.8 35.2 0.4
CA A:ASP418 4.8 15.8 1.0
N A:ASP332 4.9 13.8 1.0
O2G P:ATP701 5.0 19.2 0.4

Reference:

A.M.Kaminski, K.K.Chiruvella, D.A.Ramsden, T.A.Kunkel, K.Bebenek, L.C.Pedersen. Unexpected Behavior of Dna Polymerase Mu Opposite Template 8-Oxo-7,8-Dihydro-2'-Guanosine. Nucleic Acids Res. V. 47 9410 2019.
ISSN: ESSN 1362-4962
PubMed: 31435651
DOI: 10.1093/NAR/GKZ680
Page generated: Sun Oct 6 05:48:17 2024

Last articles

Zn in 9JYW
Zn in 9IR4
Zn in 9IR3
Zn in 9GMX
Zn in 9GMW
Zn in 9JEJ
Zn in 9ERF
Zn in 9ERE
Zn in 9EGV
Zn in 9EGW
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy