Manganese in PDB 6nts: Protein Phosphatase 2A (Aalpha-B56ALPHA-Calpha) Holoenzyme in Complex with A Small Molecule Activator of PP2A (Smap)

All present enzymatic activity of Protein Phosphatase 2A (Aalpha-B56ALPHA-Calpha) Holoenzyme in Complex with A Small Molecule Activator of PP2A (Smap):
3.1.3.16;

The structure of Protein Phosphatase 2A (Aalpha-B56ALPHA-Calpha) Holoenzyme in Complex with A Small Molecule Activator of PP2A (Smap) also contains other interesting chemical elements:

Fluorine

(F)

3 atoms

The binding sites of Manganese atom in the Protein Phosphatase 2A (Aalpha-B56ALPHA-Calpha) Holoenzyme in Complex with A Small Molecule Activator of PP2A (Smap) (pdb code 6nts). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total 2 binding sites of Manganese where determined in the Protein Phosphatase 2A (Aalpha-B56ALPHA-Calpha) Holoenzyme in Complex with A Small Molecule Activator of PP2A (Smap), PDB code: 6nts:
Jump to Manganese binding site number: 1; 2;

Manganese binding site 1 out of 2 in the Protein Phosphatase 2A (Aalpha-B56ALPHA-Calpha) Holoenzyme in Complex with A Small Molecule Activator of PP2A (Smap)


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of Protein Phosphatase 2A (Aalpha-B56ALPHA-Calpha) Holoenzyme in Complex with A Small Molecule Activator of PP2A (Smap) within 5.0Å range: probe atom residue distance (Å) B Occ C:Mn401 b:0.1 occ:1.00 ND1 C:HIS241 1.9 0.5 1.0 OD1 C:ASN117 2.4 0.7 1.0 NE2 C:HIS167 2.4 0.1 1.0 OD2 C:ASP85 2.7 0.8 1.0 CE1 C:HIS241 2.7 0.5 1.0 CG C:HIS241 3.1 0.5 1.0 CE1 C:HIS167 3.2 0.1 1.0 MN C:MN402 3.2 0.3 1.0 CD2 C:HIS118 3.3 1.0 1.0 CG C:ASN117 3.4 0.7 1.0 CD2 C:HIS167 3.5 0.1 1.0 CG C:ASP85 3.5 0.8 1.0 NE2 C:HIS118 3.5 1.0 1.0 CA C:HIS241 3.6 0.5 1.0 CB C:HIS241 3.6 0.5 1.0 OD1 C:ASP85 3.7 0.8 1.0 ND2 C:ASN117 3.8 0.7 1.0 NE2 C:HIS241 3.9 0.5 1.0 CD2 C:HIS241 4.1 0.5 1.0 O C:HIS241 4.2 0.5 1.0 ND1 C:HIS167 4.4 0.1 1.0 C C:HIS241 4.4 0.5 1.0 OD2 C:ASP57 4.4 0.4 1.0 CG C:HIS167 4.5 0.1 1.0 CG C:HIS118 4.5 1.0 1.0 N C:HIS241 4.6 0.5 1.0 CB C:ASN117 4.7 0.7 1.0 CE1 C:HIS118 4.8 1.0 1.0 N C:ASN117 4.8 0.7 1.0 CB C:ASP85 4.9 0.8 1.0 O C:LEU199 4.9 0.5 1.0 OD1 C:ASP57 4.9 0.4 1.0 CG C:ASP57 5.0 0.4 1.0 N C:HIS118 5.0 1.0 1.0

Manganese binding site 2 out of 2 in the Protein Phosphatase 2A (Aalpha-B56ALPHA-Calpha) Holoenzyme in Complex with A Small Molecule Activator of PP2A (Smap)


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 2 of Protein Phosphatase 2A (Aalpha-B56ALPHA-Calpha) Holoenzyme in Complex with A Small Molecule Activator of PP2A (Smap) within 5.0Å range: probe atom residue distance (Å) B Occ C:Mn402 b:0.3 occ:1.00 OD2 C:ASP85 2.2 0.8 1.0 NE2 C:HIS59 2.2 0.8 1.0 OD2 C:ASP57 2.8 0.4 1.0 CE1 C:HIS59 3.0 0.8 1.0 MN C:MN401 3.2 0.1 1.0 CG C:ASP85 3.4 0.8 1.0 CD2 C:HIS59 3.4 0.8 1.0 CG C:ASP57 3.4 0.4 1.0 NE2 C:HIS118 3.5 1.0 1.0 O C:HIS241 3.8 0.5 1.0 CD2 C:HIS118 3.9 1.0 1.0 CB C:ASP57 3.9 0.4 1.0 CB C:ASP85 4.0 0.8 1.0 CE1 C:HIS118 4.0 1.0 1.0 OH C:TYR265 4.1 0.8 1.0 OD1 C:ASP57 4.1 0.4 1.0 ND1 C:HIS59 4.2 0.8 1.0 CA C:HIS241 4.4 0.5 1.0 OD1 C:ASP85 4.4 0.8 1.0 CG C:HIS59 4.4 0.8 1.0 ND1 C:HIS241 4.5 0.5 1.0 CG C:HIS118 4.5 1.0 1.0 C C:HIS241 4.6 0.5 1.0 ND1 C:HIS118 4.6 1.0 1.0 CE1 C:HIS167 4.7 0.1 1.0 CE1 C:PHE260 4.7 0.3 1.0 NE2 C:HIS167 4.8 0.1 1.0 CZ C:TYR265 4.9 0.8 1.0

D.Leonard, W.Huang, S.Izadmehr, C.M.O'connor, D.D.Wiredja, Z.Wang, N.Zaware, Y.Chen, D.M.Schlatzer, J.Kiselar, N.Vasireddi, S.Schuchner, A.L.Perl, M.D.Galsky, W.Xu, D.L.Brautigan, E.Ogris, D.J.Taylor, G.Narla. Selective PP2A Enhancement Through Biased Heterotrimer Stabilization. Cell 2020.
ISSN: ISSN 1097-4172
PubMed: 32315618
DOI: 10.1016/J.CELL.2020.03.038