Atomistry » Manganese » PDB 6m30-6obu » 6npz
Atomistry »
  Manganese »
    PDB 6m30-6obu »
      6npz »

Manganese in PDB 6npz: Crystal Structure of AKT1 (Aa 123-480) Kinase with A Bisubstrate

Enzymatic activity of Crystal Structure of AKT1 (Aa 123-480) Kinase with A Bisubstrate

All present enzymatic activity of Crystal Structure of AKT1 (Aa 123-480) Kinase with A Bisubstrate:
2.7.11.1;

Protein crystallography data

The structure of Crystal Structure of AKT1 (Aa 123-480) Kinase with A Bisubstrate, PDB code: 6npz was solved by N.Chu, P.A.Cole, S.B.Gabelli, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 29.82 / 2.12
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 86.321, 56.088, 92.019, 90.00, 104.56, 90.00
R / Rfree (%) 18.5 / 24.1

Other elements in 6npz:

The structure of Crystal Structure of AKT1 (Aa 123-480) Kinase with A Bisubstrate also contains other interesting chemical elements:

Vanadium (V) 1 atom

Manganese Binding Sites:

The binding sites of Manganese atom in the Crystal Structure of AKT1 (Aa 123-480) Kinase with A Bisubstrate (pdb code 6npz). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total 4 binding sites of Manganese where determined in the Crystal Structure of AKT1 (Aa 123-480) Kinase with A Bisubstrate, PDB code: 6npz:
Jump to Manganese binding site number: 1; 2; 3; 4;

Manganese binding site 1 out of 4 in 6npz

Go back to Manganese Binding Sites List in 6npz
Manganese binding site 1 out of 4 in the Crystal Structure of AKT1 (Aa 123-480) Kinase with A Bisubstrate


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of Crystal Structure of AKT1 (Aa 123-480) Kinase with A Bisubstrate within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mn501

b:48.3
occ:1.00
NE2 A:HIS354 2.2 42.5 1.0
O A:HOH749 2.5 37.2 1.0
O A:HOH706 2.5 50.2 1.0
OE2 A:GLU314 2.6 30.0 1.0
CE1 A:HIS354 3.1 45.5 1.0
CD2 A:HIS354 3.4 44.0 1.0
CD A:GLU314 3.4 30.4 1.0
OE1 A:GLU314 3.5 31.1 1.0
ND1 A:HIS354 4.3 36.8 1.0
CG A:HIS354 4.4 40.2 1.0
O F:HOH212 4.4 56.1 1.0
O A:HOH777 4.6 65.3 1.0
O F:HOH208 4.6 41.3 1.0
O F:HOH204 4.7 43.8 1.0
CG A:GLU314 4.8 31.9 1.0
CB A:PRO313 4.8 28.2 1.0
CG2 F:THR5 4.9 32.8 1.0
CG A:PRO313 4.9 30.8 1.0
O A:GLN352 4.9 34.5 1.0

Manganese binding site 2 out of 4 in 6npz

Go back to Manganese Binding Sites List in 6npz
Manganese binding site 2 out of 4 in the Crystal Structure of AKT1 (Aa 123-480) Kinase with A Bisubstrate


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 2 of Crystal Structure of AKT1 (Aa 123-480) Kinase with A Bisubstrate within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Mn503

b:76.2
occ:1.00
O B:HOH722 2.5 43.0 1.0
OE2 B:GLU314 2.7 40.3 1.0
O B:HOH731 2.8 55.8 1.0
O B:HOH709 2.8 50.3 1.0
NE2 B:HIS354 2.9 34.2 1.0
O B:HOH665 3.0 55.9 1.0
CD B:GLU314 3.5 36.3 1.0
CD2 B:HIS354 3.6 39.6 1.0
OE1 B:GLU314 3.7 29.9 1.0
O G:HOH604 3.8 46.6 1.0
O B:HOH601 3.9 41.7 1.0
CE1 B:HIS354 4.0 33.1 1.0
O G:HOH610 4.7 55.0 1.0
CG2 G:THR5 4.8 40.5 1.0
CG B:HIS354 4.8 29.4 1.0
CG B:GLU314 4.9 32.4 1.0
O B:GLN352 4.9 33.9 1.0

Manganese binding site 3 out of 4 in 6npz

Go back to Manganese Binding Sites List in 6npz
Manganese binding site 3 out of 4 in the Crystal Structure of AKT1 (Aa 123-480) Kinase with A Bisubstrate


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 3 of Crystal Structure of AKT1 (Aa 123-480) Kinase with A Bisubstrate within 5.0Å range:
probe atom residue distance (Å) B Occ
F:Mn101

b:53.9
occ:1.00
O2A F:ZXW7 1.9 74.0 1.0
OD2 A:ASP292 2.1 41.6 1.0
O A:HOH631 2.2 37.1 1.0
O F:HOH202 2.4 36.4 1.0
O2B F:ZXW7 2.4 51.7 1.0
O3B F:ZXW7 2.6 71.0 1.0
CG A:ASP292 2.9 43.9 1.0
PB F:ZXW7 3.1 51.3 1.0
OD1 A:ASP292 3.1 43.4 1.0
PA F:ZXW7 3.1 57.8 1.0
O3A F:ZXW7 3.6 54.6 1.0
PG F:ZXW7 3.8 65.5 1.0
OD1 A:ASN279 3.9 28.7 1.0
S2G F:ZXW7 4.0 65.0 1.0
O5' F:ZXW7 4.0 56.8 1.0
O F:HOH205 4.1 40.5 1.0
C5' F:ZXW7 4.1 45.7 1.0
O1A F:ZXW7 4.2 55.4 1.0
O F:HOH207 4.2 60.9 1.0
O A:HOH677 4.2 52.6 1.0
CB A:ASP292 4.4 37.8 1.0
O1B F:ZXW7 4.5 58.5 1.0
NH1 F:ARG4 4.6 35.6 1.0
O A:HOH723 4.6 38.8 1.0
O3G F:ZXW7 4.8 55.7 1.0
O1G F:ZXW7 4.9 53.8 1.0
CG A:ASN279 4.9 22.6 1.0

Manganese binding site 4 out of 4 in 6npz

Go back to Manganese Binding Sites List in 6npz
Manganese binding site 4 out of 4 in the Crystal Structure of AKT1 (Aa 123-480) Kinase with A Bisubstrate


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 4 of Crystal Structure of AKT1 (Aa 123-480) Kinase with A Bisubstrate within 5.0Å range:
probe atom residue distance (Å) B Occ
G:Mn501

b:87.0
occ:1.00
O1A G:ZXW7 1.8 85.3 1.0
OD2 B:ASP292 2.0 55.4 1.0
O G:HOH606 2.1 45.9 1.0
O1G G:ZXW7 2.2 0.5 1.0
O1B G:ZXW7 2.8 77.0 1.0
CG B:ASP292 2.8 46.3 1.0
OD1 B:ASP292 3.1 51.9 1.0
PA G:ZXW7 3.2 79.2 1.0
OD1 B:ASN279 3.3 31.1 1.0
PG G:ZXW7 3.3 86.9 1.0
PB G:ZXW7 3.6 65.5 1.0
O G:HOH601 3.7 57.5 1.0
O G:HOH605 3.7 51.8 1.0
O2A G:ZXW7 3.9 65.0 1.0
O3B G:ZXW7 3.9 78.1 1.0
O3A G:ZXW7 3.9 83.9 1.0
S2G G:ZXW7 4.0 85.9 1.0
O G:HOH603 4.1 66.4 1.0
CB B:ASP292 4.3 34.5 1.0
O5' G:ZXW7 4.4 81.1 1.0
CG B:ASN279 4.4 26.4 1.0
C5' G:ZXW7 4.6 63.5 1.0
O3G G:ZXW7 4.7 74.1 1.0
NH1 G:ARG4 4.7 40.5 1.0
ND2 B:ASN279 4.9 29.5 1.0

Reference:

N.Chu, A.L.Salguero, A.Z.Liu, Z.Chen, D.R.Dempsey, S.B.Ficarro, W.M.Alexander, J.A.Marto, Y.Li, L.M.Amzel, S.B.Gabelli, P.A.Cole. Akt Kinase Activation Mechanisms Revealed Using Protein Semisynthesis. Cell V. 174 897 2018.
ISSN: ISSN 1097-4172
PubMed: 30078705
DOI: 10.1016/J.CELL.2018.07.003
Page generated: Sun Oct 6 05:37:26 2024

Last articles

Zn in 9JYW
Zn in 9IR4
Zn in 9IR3
Zn in 9GMX
Zn in 9GMW
Zn in 9JEJ
Zn in 9ERF
Zn in 9ERE
Zn in 9EGV
Zn in 9EGW
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy