Manganese in PDB 6mcp: L. Pneumophila Effector Kinase LEGK7 (Amp-Pnp Bound) in Complex with Human MOB1A

Enzymatic activity of L. Pneumophila Effector Kinase LEGK7 (Amp-Pnp Bound) in Complex with Human MOB1A

All present enzymatic activity of L. Pneumophila Effector Kinase LEGK7 (Amp-Pnp Bound) in Complex with Human MOB1A:
2.7.11.1;

Protein crystallography data

The structure of L. Pneumophila Effector Kinase LEGK7 (Amp-Pnp Bound) in Complex with Human MOB1A, PDB code: 6mcp was solved by K.A.Beyrakhova, C.Xu, M.T.Boniecki, M.Cygler, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	48.67 / 2.50
*Space group*	C 1 2 1
*Cell size a, b, c (Å), α, β, γ (°)*	106.860, 112.430, 155.220, 90.00, 105.58, 90.00
*R / R_free (%)*	19.4 / 23.3

Other elements in 6mcp:

The structure of L. Pneumophila Effector Kinase LEGK7 (Amp-Pnp Bound) in Complex with Human MOB1A also contains other interesting chemical elements:

Zinc

(Zn)

2 atoms

Manganese Binding Sites:

The binding sites of Manganese atom in the L. Pneumophila Effector Kinase LEGK7 (Amp-Pnp Bound) in Complex with Human MOB1A (pdb code 6mcp). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total only one binding site of Manganese was determined in the L. Pneumophila Effector Kinase LEGK7 (Amp-Pnp Bound) in Complex with Human MOB1A, PDB code: 6mcp:

Manganese binding site 1 out of 1 in 6mcp

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Manganese Binding Sites List in 6mcp

Manganese binding site 1 out of 1 in the L. Pneumophila Effector Kinase LEGK7 (Amp-Pnp Bound) in Complex with Human MOB1A

Mono view

Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of L. Pneumophila Effector Kinase LEGK7 (Amp-Pnp Bound) in Complex with Human MOB1A within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
C:Mn601 b:95.9 occ:1.00	O1G	C:ANP610	2.2	0.9	0.8
	OD1	C:ASN312	2.2	0.3	1.0
	OD1	C:ASP324	2.2	0.6	1.0
	O1A	C:ANP610	2.2	93.5	0.8
	CG	C:ASP324	3.1	0.7	1.0
	CG	C:ASN312	3.1	87.3	1.0
	PG	C:ANP610	3.5	0.9	0.8
	ND2	C:ASN312	3.5	89.0	1.0
	CB	C:ASP324	3.6	93.2	1.0
	PA	C:ANP610	3.8	94.6	0.8
	N3B	C:ANP610	3.8	0.6	0.8
	O1B	C:ANP610	3.9	0.6	0.8
	O2G	C:ANP610	4.0	0.9	0.8
	OD2	C:ASP324	4.1	0.7	1.0
	O2A	C:ANP610	4.3	95.1	0.8
	PB	C:ANP610	4.4	0.4	0.8
	CB	C:ASN312	4.4	74.4	1.0
	O3A	C:ANP610	4.4	0.7	0.8
	OD2	C:ASP307	4.6	72.0	1.0
	O5'	C:ANP610	4.7	86.1	0.8
	O3G	C:ANP610	4.7	0.1	0.8
	CA	C:ASN312	4.7	63.5	1.0
	C5'	C:ANP610	4.9	79.3	0.8
	CE	C:LYS309	5.0	61.5	1.0

Reference:

P.-C.Lee, K.Beyrakhova, C.Xu, M.T.Boniecki, M.Lee, A.M.Grishin, M.P.Machner, M.Cygler. Structural Insight Into A Bacterial Kinase-Host Activator Complex That Exploits the Mammalian Hippo Pathway To Be Published.

Page generated: Sun Oct 6 05:29:59 2024

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