Atomistry » Manganese » PDB 6fxt-6hzn » 6gj0
Atomistry »
  Manganese »
    PDB 6fxt-6hzn »
      6gj0 »

Manganese in PDB 6gj0: Human Impase with Mn

Enzymatic activity of Human Impase with Mn

All present enzymatic activity of Human Impase with Mn:
3.1.3.25; 3.1.3.94;

Protein crystallography data

The structure of Human Impase with Mn, PDB code: 6gj0 was solved by L.V.Kraft, S.M.Roe, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 42.47 / 1.73
Space group P 32 2 1
Cell size a, b, c (Å), α, β, γ (°) 84.940, 84.940, 152.510, 90.00, 90.00, 120.00
R / Rfree (%) 17.1 / 21

Manganese Binding Sites:

The binding sites of Manganese atom in the Human Impase with Mn (pdb code 6gj0). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total 6 binding sites of Manganese where determined in the Human Impase with Mn, PDB code: 6gj0:
Jump to Manganese binding site number: 1; 2; 3; 4; 5; 6;

Manganese binding site 1 out of 6 in 6gj0

Go back to Manganese Binding Sites List in 6gj0
Manganese binding site 1 out of 6 in the Human Impase with Mn


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of Human Impase with Mn within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mn301

b:18.0
occ:1.00
OE2 A:GLU70 2.1 17.4 1.0
O A:HOH429 2.2 21.7 1.0
O A:HOH456 2.2 16.9 1.0
O2S A:MES307 2.2 16.7 1.0
O A:HOH432 2.2 18.6 1.0
O1S A:MES307 2.4 17.5 1.0
S A:MES307 2.8 23.7 1.0
CD A:GLU70 3.2 16.6 1.0
OE1 A:GLU70 3.6 14.1 1.0
O3S A:MES307 3.9 13.5 1.0
O A:LEU42 3.9 16.0 1.0
O A:HOH622 3.9 35.7 1.0
NZ A:LYS36 3.9 17.2 1.0
MN A:MN302 4.0 14.0 1.0
C8 A:MES307 4.0 10.9 1.0
OD1 A:ASP41 4.1 22.1 1.0
O A:HOH528 4.1 20.5 1.0
OE2 A:GLU71 4.2 15.6 1.0
O A:HOH585 4.4 39.4 1.0
OG1 A:THR95 4.4 16.1 1.0
CG A:GLU70 4.5 14.5 1.0
O A:HOH492 4.5 13.2 1.0
C5 A:MES307 4.5 42.7 1.0
CD A:LYS36 4.7 21.8 1.0
O A:HOH574 4.8 37.4 1.0
C7 A:MES307 4.9 36.6 1.0
CE A:LYS36 4.9 24.1 1.0
O A:HOH514 4.9 17.3 1.0
CB A:THR95 4.9 15.1 1.0
N4 A:MES307 5.0 33.2 1.0

Manganese binding site 2 out of 6 in 6gj0

Go back to Manganese Binding Sites List in 6gj0
Manganese binding site 2 out of 6 in the Human Impase with Mn


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 2 of Human Impase with Mn within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mn302

b:14.0
occ:1.00
OE1 A:GLU70 2.1 14.1 1.0
OD1 A:ASP90 2.2 13.1 1.0
O A:ILE92 2.2 13.8 1.0
O3S A:MES307 2.2 13.5 1.0
O A:HOH492 2.2 13.2 1.0
O1S A:MES307 2.3 17.5 1.0
S A:MES307 2.8 23.7 1.0
CG A:ASP90 3.1 15.2 1.0
C A:ILE92 3.2 14.0 1.0
CD A:GLU70 3.2 16.6 1.0
OD2 A:ASP90 3.3 16.4 1.0
OE2 A:GLU70 3.6 17.4 1.0
MN A:MN303 3.7 16.0 1.0
O2S A:MES307 3.8 16.7 1.0
N A:ASP93 3.9 11.7 1.0
C8 A:MES307 3.9 10.9 1.0
CA A:ASP93 3.9 12.3 1.0
MN A:MN301 4.0 18.0 1.0
OG1 A:THR95 4.0 16.1 1.0
N A:ILE92 4.0 14.7 1.0
CA A:ILE92 4.1 13.4 1.0
O A:HOH528 4.1 20.5 1.0
OE2 A:GLU71 4.3 15.6 1.0
OD2 A:ASP47 4.3 17.1 1.0
CD A:PRO91 4.4 13.6 1.0
CB A:ASP90 4.4 13.6 1.0
CG A:GLU70 4.5 14.5 1.0
O A:HOH456 4.5 16.9 1.0
CB A:GLU70 4.6 14.2 1.0
CB A:ILE92 4.7 15.6 1.0
N A:PRO91 4.7 12.7 1.0
CA A:ASP90 4.8 10.9 1.0
CG A:PRO91 4.8 13.0 1.0
OD1 A:ASP93 4.8 15.9 1.0
C A:ASP90 4.8 12.9 1.0
CB A:ASP93 4.9 11.1 1.0
N A:GLY94 4.9 13.7 1.0
C A:ASP93 5.0 14.3 1.0

Manganese binding site 3 out of 6 in 6gj0

Go back to Manganese Binding Sites List in 6gj0
Manganese binding site 3 out of 6 in the Human Impase with Mn


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 3 of Human Impase with Mn within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Mn303

b:16.0
occ:1.00
OD1 A:ASP220 2.0 18.7 1.0
O3S A:MES307 2.1 13.5 1.0
OD2 A:ASP90 2.1 16.4 1.0
OD1 A:ASP93 2.1 15.9 1.0
O1 A:GOL304 2.3 20.1 1.0
O A:HOH528 2.5 20.5 1.0
CG A:ASP93 3.2 16.8 1.0
CG A:ASP220 3.2 16.6 1.0
CG A:ASP90 3.3 15.2 1.0
S A:MES307 3.4 23.7 1.0
C1 A:GOL304 3.7 39.8 1.0
O2S A:MES307 3.7 16.7 1.0
MN A:MN302 3.7 14.0 1.0
O2 A:GOL304 3.8 20.6 1.0
OD1 A:ASP90 3.8 13.1 1.0
CB A:ASP93 3.8 11.1 1.0
CA A:ASP93 3.9 12.3 1.0
OD2 A:ASP220 3.9 16.0 1.0
O A:HOH446 3.9 24.1 1.0
C7 A:MES307 4.0 36.6 1.0
CD1 A:TRP219 4.1 13.5 1.0
OE1 A:GLU70 4.1 14.1 1.0
C8 A:MES307 4.1 10.9 1.0
OD2 A:ASP93 4.2 15.3 1.0
NE1 A:TRP219 4.3 14.1 1.0
CB A:ASP220 4.3 15.1 1.0
C2 A:GOL304 4.4 27.7 1.0
O1S A:MES307 4.5 17.5 1.0
CB A:ASP90 4.5 13.6 1.0
CA A:ASP220 4.5 15.2 1.0
O A:ILE92 4.7 13.8 1.0
N A:GLY94 4.7 13.7 1.0
C A:ASP93 4.8 14.3 1.0
CD A:GLU70 4.9 16.6 1.0
N A:ASP93 4.9 11.7 1.0

Manganese binding site 4 out of 6 in 6gj0

Go back to Manganese Binding Sites List in 6gj0
Manganese binding site 4 out of 6 in the Human Impase with Mn


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 4 of Human Impase with Mn within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Mn301

b:17.7
occ:1.00
OD1 B:ASP220 2.0 20.8 1.0
O1S B:MES307 2.0 16.8 1.0
OD1 B:ASP93 2.2 15.6 1.0
OD2 B:ASP90 2.2 13.7 1.0
O3 B:GOL304 2.3 21.3 1.0
O B:HOH517 2.4 20.7 1.0
CG B:ASP93 3.2 17.2 1.0
CG B:ASP220 3.2 19.8 1.0
CG B:ASP90 3.3 13.2 1.0
S B:MES307 3.3 22.6 1.0
C3 B:GOL304 3.6 30.9 1.0
O2S B:MES307 3.7 18.3 1.0
MN B:MN302 3.7 14.4 1.0
OD1 B:ASP90 3.8 13.4 1.0
CB B:ASP93 3.8 14.4 1.0
CA B:ASP93 3.9 12.6 1.0
O2 B:GOL304 3.9 21.1 1.0
O B:HOH413 3.9 25.1 1.0
OD2 B:ASP220 3.9 19.6 1.0
C8 B:MES307 4.0 10.5 1.0
OE1 B:GLU70 4.2 14.3 1.0
OD2 B:ASP93 4.2 15.4 1.0
CD1 B:TRP219 4.2 15.4 1.0
CB B:ASP220 4.3 16.9 1.0
C2 B:GOL304 4.3 28.1 1.0
NE1 B:TRP219 4.4 15.1 1.0
O3S B:MES307 4.4 17.2 1.0
CA B:ASP220 4.5 16.0 1.0
CB B:ASP90 4.5 16.6 1.0
O B:ILE92 4.7 12.4 1.0
N B:GLY94 4.7 14.0 1.0
C B:ASP93 4.8 14.1 1.0
CD B:GLU70 4.9 17.0 1.0
N B:ASP93 4.9 13.1 1.0

Manganese binding site 5 out of 6 in 6gj0

Go back to Manganese Binding Sites List in 6gj0
Manganese binding site 5 out of 6 in the Human Impase with Mn


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 5 of Human Impase with Mn within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Mn302

b:14.4
occ:1.00
OD1 B:ASP90 2.1 13.4 1.0
OE1 B:GLU70 2.1 14.3 1.0
O B:HOH472 2.2 15.1 1.0
O B:ILE92 2.2 12.4 1.0
O1S B:MES307 2.3 16.8 1.0
O3S B:MES307 2.4 17.2 1.0
S B:MES307 2.8 22.6 1.0
CG B:ASP90 3.1 13.2 1.0
CD B:GLU70 3.1 17.0 1.0
C B:ILE92 3.2 14.0 1.0
OD2 B:ASP90 3.4 13.7 1.0
OE2 B:GLU70 3.5 17.4 1.0
MN B:MN301 3.7 17.7 1.0
O2S B:MES307 3.8 18.3 1.0
N B:ASP93 3.9 13.1 1.0
MN B:MN303 3.9 18.2 1.0
CA B:ASP93 3.9 12.6 1.0
OG1 B:THR95 4.0 13.8 1.0
N B:ILE92 4.0 14.0 1.0
O B:HOH517 4.1 20.7 1.0
CA B:ILE92 4.1 11.4 1.0
C8 B:MES307 4.1 10.5 1.0
OE2 B:GLU71 4.3 18.9 1.0
OD2 B:ASP47 4.3 19.9 1.0
CD B:PRO91 4.4 16.6 1.0
CG B:GLU70 4.4 13.4 1.0
CB B:ASP90 4.5 16.6 1.0
O B:HOH447 4.5 15.5 1.0
CB B:GLU70 4.6 15.8 1.0
CB B:ILE92 4.7 12.8 1.0
N B:PRO91 4.7 16.2 1.0
CG B:PRO91 4.8 17.7 1.0
CA B:ASP90 4.8 14.4 1.0
C B:ASP90 4.8 13.1 1.0
OD1 B:ASP93 4.8 15.6 1.0
CB B:ASP93 4.9 14.4 1.0
N B:GLY94 4.9 14.0 1.0
C B:ASP93 4.9 14.1 1.0

Manganese binding site 6 out of 6 in 6gj0

Go back to Manganese Binding Sites List in 6gj0
Manganese binding site 6 out of 6 in the Human Impase with Mn


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 6 of Human Impase with Mn within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Mn303

b:18.2
occ:1.00
OE2 B:GLU70 2.0 17.4 1.0
O B:HOH428 2.1 19.4 1.0
O2S B:MES307 2.1 18.3 1.0
O B:HOH447 2.2 15.5 1.0
O B:HOH436 2.3 20.9 1.0
O3S B:MES307 2.4 17.2 1.0
S B:MES307 2.8 22.6 1.0
CD B:GLU70 3.2 17.0 1.0
OE1 B:GLU70 3.6 14.3 1.0
O1S B:MES307 3.8 16.8 1.0
MN B:MN302 3.9 14.4 1.0
O B:LEU42 3.9 15.8 1.0
NZ B:LYS36 3.9 18.2 1.0
O B:HOH578 4.0 34.4 1.0
OD1 B:ASP41 4.1 23.2 1.0
C8 B:MES307 4.1 10.5 1.0
OE2 B:GLU71 4.1 18.9 1.0
O B:HOH517 4.1 20.7 1.0
O B:HOH496 4.2 29.6 1.0
OG1 B:THR95 4.3 13.8 1.0
C7 B:MES307 4.3 26.1 1.0
O B:HOH472 4.4 15.1 1.0
CG B:GLU70 4.4 13.4 1.0
CD B:LYS36 4.6 24.8 1.0
O B:HOH559 4.7 36.8 1.0
CB B:THR95 4.8 13.2 1.0
CE B:LYS36 4.8 27.9 1.0
O B:HOH501 4.9 16.2 1.0

Reference:

L.Kraft, S.M.Roe, R.Gill, J.R.Atack. Co-Crystallization of Human Inositol Monophosphatase with the Lithium Mimetic L-690,330. Acta Crystallogr D Struct V. 74 973 2018BIOL.
ISSN: ISSN 2059-7983
PubMed: 30289407
DOI: 10.1107/S2059798318010380
Page generated: Sun Oct 6 04:44:44 2024

Last articles

Zn in 9JPJ
Zn in 9JP7
Zn in 9JPK
Zn in 9JPL
Zn in 9GN6
Zn in 9GN7
Zn in 9GKU
Zn in 9GKW
Zn in 9GKX
Zn in 9GL0
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy