Manganese in PDB 6f0w: Prolyl Hydroxylase in Complex with Hypoxia Inducible Factor Oxygen Degradation Domain Peptide Fragment From Trichoplax Adhaerens

The structure of Prolyl Hydroxylase in Complex with Hypoxia Inducible Factor Oxygen Degradation Domain Peptide Fragment From Trichoplax Adhaerens, PDB code: 6f0w was solved by M.A.Mcdonough, A.Boleininger, C.J.Schofield, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	37.48 / 1.30
Space group	P 1
Cell size a, b, c (Å), α, β, γ (°)	40.841, 41.321, 42.076, 114.06, 95.67, 103.69
R / Rfree (%)	13.8 / 16.2

The binding sites of Manganese atom in the Prolyl Hydroxylase in Complex with Hypoxia Inducible Factor Oxygen Degradation Domain Peptide Fragment From Trichoplax Adhaerens (pdb code 6f0w). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total only one binding site of Manganese was determined in the Prolyl Hydroxylase in Complex with Hypoxia Inducible Factor Oxygen Degradation Domain Peptide Fragment From Trichoplax Adhaerens, PDB code: 6f0w:

Manganese binding site 1 out of 1 in the Prolyl Hydroxylase in Complex with Hypoxia Inducible Factor Oxygen Degradation Domain Peptide Fragment From Trichoplax Adhaerens


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of Prolyl Hydroxylase in Complex with Hypoxia Inducible Factor Oxygen Degradation Domain Peptide Fragment From Trichoplax Adhaerens within 5.0Å range: probe atom residue distance (Å) B Occ A:Mn402 b:14.7 occ:1.00 O2' A:OGA401 2.0 9.2 1.0 O1 A:OGA401 2.0 10.0 1.0 OD1 A:ASP211 2.0 8.7 1.0 NE2 A:HIS270 2.1 9.5 1.0 NE2 A:HIS209 2.1 9.8 1.0 O A:HOH514 2.2 9.8 1.0 C2 A:OGA401 2.7 13.4 1.0 C1 A:OGA401 2.9 12.8 1.0 CG A:ASP211 3.0 9.4 1.0 CE1 A:HIS209 3.0 11.5 1.0 CE1 A:HIS270 3.1 10.0 1.0 CD2 A:HIS270 3.1 11.2 1.0 CD2 A:HIS209 3.2 11.5 1.0 OD2 A:ASP211 3.4 10.9 1.0 N1 A:OGA401 4.0 13.5 1.0 O2 A:OGA401 4.1 14.3 1.0 ND1 A:HIS209 4.2 11.6 1.0 ND1 A:HIS270 4.2 10.5 1.0 O A:HOH555 4.2 15.2 1.0 CG A:HIS270 4.2 10.7 1.0 CG A:HIS209 4.3 11.4 1.0 CB A:ASP211 4.4 10.6 1.0 CG S:PRO486 4.5 13.8 1.0 C4 A:OGA401 4.6 12.7 1.0 CE1 A:TYR206 4.7 12.6 1.0 CA A:ASP211 4.8 10.4 1.0 CD S:PRO486 4.8 13.2 1.0 CZ A:PHE262 4.9 12.4 1.0 N A:ASP211 4.9 9.8 1.0 CZ2 A:TRP285 5.0 13.3 1.0

K.Lippl, A.Boleininger, M.A.Mcdonough, M.I.Abboud, H.Tarhonskaya, R.Chowdhury, C.Loenarz, C.J.Schofield. Born to Sense: Biophysical Analyses of the Oxygen Sensing Prolyl Hydroxylase From the Simplest Animal Trichoplax Adhaerens. Hypoxia (Auckl) V. 6 57 2018.
ISSN: ISSN 2324-1128
PubMed: 30519597
DOI: 10.2147/HP.S174655