Manganese in PDB 6ezm: Imidazoleglycerol-Phosphate Dehydratase From Saccharomyces Cerevisiae

All present enzymatic activity of Imidazoleglycerol-Phosphate Dehydratase From Saccharomyces Cerevisiae:
4.2.1.19;

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 20; Page 3, Binding sites: 21 - 30; Page 4, Binding sites: 31 - 40; Page 5, Binding sites: 41 - 48;

Binding sites:

The binding sites of Manganese atom in the Imidazoleglycerol-Phosphate Dehydratase From Saccharomyces Cerevisiae (pdb code 6ezm). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total 48 binding sites of Manganese where determined in the Imidazoleglycerol-Phosphate Dehydratase From Saccharomyces Cerevisiae, PDB code: 6ezm:
Jump to Manganese binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Manganese binding site 1 out of 48 in the Imidazoleglycerol-Phosphate Dehydratase From Saccharomyces Cerevisiae


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of Imidazoleglycerol-Phosphate Dehydratase From Saccharomyces Cerevisiae within 5.0Å range: probe atom residue distance (Å) B Occ U:Mn301 b:35.9 occ:1.00 NE2 U:HIS90 2.1 26.5 1.0 OE1 U:GLU94 2.1 27.2 1.0 NE2 L:HIS187 2.2 16.3 1.0 NE2 U:HIS162 2.3 19.9 1.0 N4 U:5LD306 2.5 18.4 0.3 CE1 U:HIS162 2.5 19.9 1.0 CE1 U:HIS90 2.7 26.5 1.0 CE1 L:HIS187 2.7 16.3 1.0 CD U:GLU94 2.8 27.2 1.0 OE2 U:GLU94 3.2 27.2 1.0 CD2 U:HIS90 3.3 26.5 1.0 C3 U:5LD306 3.4 18.4 0.3 CD2 L:HIS187 3.4 16.3 1.0 C5 U:5LD306 3.5 18.4 0.3 CD2 U:HIS162 3.6 19.9 1.0 ND1 U:HIS162 3.7 19.9 1.0 OD2 L:ASP125 3.7 16.7 1.0 ND1 U:HIS90 3.9 26.5 1.0 ND1 L:HIS187 4.0 16.3 1.0 CG U:GLU94 4.0 27.2 1.0 CG U:HIS162 4.3 19.9 1.0 CG U:HIS90 4.3 26.5 1.0 CG L:HIS187 4.3 16.3 1.0 CB U:GLU94 4.4 27.2 1.0 N2 U:5LD306 4.6 18.4 0.3 N1 U:5LD306 4.7 18.4 0.3 CG L:ASP125 4.7 16.7 1.0 ND2 L:ASN184 4.8 18.3 1.0 CB L:ASP125 4.9 16.7 1.0

Manganese binding site 2 out of 48 in the Imidazoleglycerol-Phosphate Dehydratase From Saccharomyces Cerevisiae


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 2 of Imidazoleglycerol-Phosphate Dehydratase From Saccharomyces Cerevisiae within 5.0Å range: probe atom residue distance (Å) B Occ U:Mn302 b:39.7 occ:0.50 O13 U:5LD303 1.9 30.9 0.3 NE2 D:HIS91 2.0 31.5 1.0 OE1 U:GLU190 2.2 15.8 1.0 NE2 U:HIS64 2.3 21.7 1.0 NE2 U:HIS186 2.3 16.4 1.0 CE1 D:HIS91 2.6 31.5 1.0 N1 U:5LD303 2.7 30.9 0.3 CD U:GLU190 3.0 15.8 1.0 CD2 U:HIS64 3.1 21.7 1.0 OE2 U:GLU190 3.2 15.8 1.0 CE1 U:HIS186 3.2 16.4 1.0 C7 U:5LD303 3.3 30.9 0.3 CD2 D:HIS91 3.3 31.5 1.0 CE1 U:HIS64 3.3 21.7 1.0 CD2 U:HIS186 3.3 16.4 1.0 C5 U:5LD303 3.6 30.9 0.3 N2 U:5LD303 3.8 30.9 0.3 ND1 D:HIS91 3.9 31.5 1.0 C6 U:5LD303 3.9 30.9 0.3 CG D:HIS91 4.2 31.5 1.0 CG U:GLU190 4.3 15.8 1.0 CG U:HIS64 4.3 21.7 1.0 C8 U:5LD303 4.3 30.9 0.3 ND1 U:HIS186 4.4 16.4 1.0 ND1 U:HIS64 4.4 21.7 1.0 CG U:HIS186 4.5 16.4 1.0 CB U:GLU190 4.7 15.8 1.0 N4 U:5LD303 4.8 30.9 0.3 C3 U:5LD303 4.9 30.9 0.3

Manganese binding site 3 out of 48 in the Imidazoleglycerol-Phosphate Dehydratase From Saccharomyces Cerevisiae


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 3 of Imidazoleglycerol-Phosphate Dehydratase From Saccharomyces Cerevisiae within 5.0Å range: probe atom residue distance (Å) B Occ U:Mn304 b:29.9 occ:1.00 NE2 D:HIS90 2.1 29.3 1.0 OE1 D:GLU94 2.1 30.4 1.0 NE2 U:HIS187 2.2 15.5 1.0 NE2 D:HIS162 2.3 22.5 1.0 N4 U:5LD303 2.5 30.9 0.3 CE1 D:HIS162 2.5 22.5 1.0 CE1 D:HIS90 2.7 29.3 1.0 CE1 U:HIS187 2.7 15.5 1.0 CD D:GLU94 2.8 30.4 1.0 OE2 D:GLU94 3.2 30.4 1.0 CD2 D:HIS90 3.3 29.3 1.0 C3 U:5LD303 3.4 30.9 0.3 CD2 U:HIS187 3.4 15.5 1.0 C5 U:5LD303 3.5 30.9 0.3 CD2 D:HIS162 3.6 22.5 1.0 ND1 D:HIS162 3.7 22.5 1.0 OD2 U:ASP125 3.8 15.4 1.0 ND1 D:HIS90 3.9 29.3 1.0 ND1 U:HIS187 4.0 15.5 1.0 CG D:GLU94 4.0 30.4 1.0 CG D:HIS162 4.3 22.5 1.0 CG D:HIS90 4.3 29.3 1.0 CG U:HIS187 4.3 15.5 1.0 CB D:GLU94 4.4 30.4 1.0 N2 U:5LD303 4.5 30.9 0.3 N1 U:5LD303 4.7 30.9 0.3 CG U:ASP125 4.7 15.4 1.0 ND2 U:ASN184 4.8 17.4 1.0 CB U:ASP125 5.0 15.4 1.0

Manganese binding site 4 out of 48 in the Imidazoleglycerol-Phosphate Dehydratase From Saccharomyces Cerevisiae


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 4 of Imidazoleglycerol-Phosphate Dehydratase From Saccharomyces Cerevisiae within 5.0Å range: probe atom residue distance (Å) B Occ U:Mn305 b:25.9 occ:0.50 O13 U:5LD306 1.9 18.4 0.3 NE2 U:HIS91 2.0 29.0 1.0 OE1 L:GLU190 2.1 16.9 1.0 NE2 L:HIS64 2.3 22.6 1.0 NE2 L:HIS186 2.3 17.0 1.0 CE1 U:HIS91 2.6 29.0 1.0 N1 U:5LD306 2.7 18.4 0.3 CD L:GLU190 2.9 16.9 1.0 CD2 L:HIS64 3.1 22.6 1.0 OE2 L:GLU190 3.2 16.9 1.0 CE1 L:HIS186 3.2 17.0 1.0 C7 U:5LD306 3.3 18.4 0.3 CD2 U:HIS91 3.3 29.0 1.0 CE1 L:HIS64 3.3 22.6 1.0 CD2 L:HIS186 3.3 17.0 1.0 C5 U:5LD306 3.6 18.4 0.3 N2 U:5LD306 3.8 18.4 0.3 ND1 U:HIS91 3.8 29.0 1.0 C6 U:5LD306 3.9 18.4 0.3 CG U:HIS91 4.2 29.0 1.0 CG L:GLU190 4.3 16.9 1.0 CG L:HIS64 4.3 22.6 1.0 C8 U:5LD306 4.3 18.4 0.3 ND1 L:HIS186 4.4 17.0 1.0 ND1 L:HIS64 4.4 22.6 1.0 CG L:HIS186 4.5 17.0 1.0 CB L:GLU190 4.7 16.9 1.0 N4 U:5LD306 4.8 18.4 0.3 C3 U:5LD306 4.9 18.4 0.3

Manganese binding site 5 out of 48 in the Imidazoleglycerol-Phosphate Dehydratase From Saccharomyces Cerevisiae


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 5 of Imidazoleglycerol-Phosphate Dehydratase From Saccharomyces Cerevisiae within 5.0Å range: probe atom residue distance (Å) B Occ A:Mn401 b:59.5 occ:0.50 O13 A:5LD402 1.9 41.2 0.3 NE2 Q:HIS91 2.0 29.0 1.0 OE1 A:GLU190 2.1 18.2 1.0 NE2 A:HIS64 2.3 24.0 1.0 NE2 A:HIS186 2.3 18.5 1.0 CE1 Q:HIS91 2.6 29.0 1.0 N1 A:5LD402 2.7 41.2 0.3 CD A:GLU190 2.9 18.2 1.0 CD2 A:HIS64 3.1 24.0 1.0 OE2 A:GLU190 3.2 18.2 1.0 CE1 A:HIS186 3.2 18.5 1.0 C7 A:5LD402 3.3 41.2 0.3 CD2 Q:HIS91 3.3 29.0 1.0 CE1 A:HIS64 3.3 24.0 1.0 CD2 A:HIS186 3.4 18.5 1.0 C5 A:5LD402 3.6 41.2 0.3 N2 A:5LD402 3.8 41.2 0.3 ND1 Q:HIS91 3.8 29.0 1.0 C6 A:5LD402 3.9 41.2 0.3 CG Q:HIS91 4.2 29.0 1.0 CG A:GLU190 4.3 18.2 1.0 CG A:HIS64 4.3 24.0 1.0 C8 A:5LD402 4.3 41.2 0.3 ND1 A:HIS64 4.4 24.0 1.0 ND1 A:HIS186 4.4 18.5 1.0 CG A:HIS186 4.5 18.5 1.0 CB A:GLU190 4.7 18.2 1.0 N4 A:5LD402 4.8 41.2 0.3 C3 A:5LD402 4.9 41.2 0.3

Manganese binding site 6 out of 48 in the Imidazoleglycerol-Phosphate Dehydratase From Saccharomyces Cerevisiae


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 6 of Imidazoleglycerol-Phosphate Dehydratase From Saccharomyces Cerevisiae within 5.0Å range: probe atom residue distance (Å) B Occ A:Mn403 b:33.1 occ:1.00 NE2 A:HIS90 2.1 28.2 1.0 OE1 A:GLU94 2.1 29.2 1.0 NE2 V:HIS187 2.2 16.8 1.0 NE2 A:HIS162 2.3 22.1 1.0 CE1 A:HIS162 2.5 22.1 1.0 N4 A:5LD406 2.5 27.9 0.3 CE1 A:HIS90 2.7 28.2 1.0 CE1 V:HIS187 2.7 16.8 1.0 CD A:GLU94 2.8 29.2 1.0 OE2 A:GLU94 3.2 29.2 1.0 CD2 A:HIS90 3.3 28.2 1.0 C3 A:5LD406 3.4 27.9 0.3 CD2 V:HIS187 3.4 16.8 1.0 CD2 A:HIS162 3.5 22.1 1.0 C5 A:5LD406 3.6 27.9 0.3 ND1 A:HIS162 3.7 22.1 1.0 OD2 V:ASP125 3.7 16.8 1.0 ND1 A:HIS90 3.9 28.2 1.0 ND1 V:HIS187 4.0 16.8 1.0 CG A:GLU94 4.0 29.2 1.0 CG A:HIS162 4.2 22.1 1.0 CG A:HIS90 4.3 28.2 1.0 CG V:HIS187 4.3 16.8 1.0 CB A:GLU94 4.4 29.2 1.0 N2 A:5LD406 4.6 27.9 0.3 CG V:ASP125 4.7 16.8 1.0 N1 A:5LD406 4.7 27.9 0.3 ND2 V:ASN184 4.7 18.8 1.0 CB V:ASP125 4.9 16.8 1.0

Manganese binding site 7 out of 48 in the Imidazoleglycerol-Phosphate Dehydratase From Saccharomyces Cerevisiae


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 7 of Imidazoleglycerol-Phosphate Dehydratase From Saccharomyces Cerevisiae within 5.0Å range: probe atom residue distance (Å) B Occ A:Mn404 b:23.8 occ:1.00 NE2 Q:HIS90 2.1 26.9 1.0 OE1 Q:GLU94 2.1 27.8 1.0 NE2 A:HIS187 2.2 17.9 1.0 NE2 Q:HIS162 2.3 20.6 1.0 CE1 Q:HIS162 2.5 20.6 1.0 N4 A:5LD402 2.5 41.2 0.3 CE1 Q:HIS90 2.7 26.9 1.0 CE1 A:HIS187 2.7 17.9 1.0 CD Q:GLU94 2.8 27.8 1.0 OE2 Q:GLU94 3.2 27.8 1.0 CD2 Q:HIS90 3.3 26.9 1.0 CD2 A:HIS187 3.4 17.9 1.0 C3 A:5LD402 3.4 41.2 0.3 CD2 Q:HIS162 3.5 20.6 1.0 C5 A:5LD402 3.5 41.2 0.3 ND1 Q:HIS162 3.7 20.6 1.0 OD2 A:ASP125 3.7 18.0 1.0 ND1 Q:HIS90 3.9 26.9 1.0 ND1 A:HIS187 4.0 17.9 1.0 CG Q:GLU94 4.0 27.8 1.0 CG Q:HIS162 4.2 20.6 1.0 CG Q:HIS90 4.3 26.9 1.0 CG A:HIS187 4.3 17.9 1.0 CB Q:GLU94 4.4 27.8 1.0 N2 A:5LD402 4.6 41.2 0.3 CG A:ASP125 4.7 18.0 1.0 N1 A:5LD402 4.7 41.2 0.3 ND2 A:ASN184 4.7 20.0 1.0 CB A:ASP125 4.9 18.0 1.0

Manganese binding site 8 out of 48 in the Imidazoleglycerol-Phosphate Dehydratase From Saccharomyces Cerevisiae


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 8 of Imidazoleglycerol-Phosphate Dehydratase From Saccharomyces Cerevisiae within 5.0Å range: probe atom residue distance (Å) B Occ A:Mn405 b:36.9 occ:0.50 O13 A:5LD406 1.9 27.9 0.3 NE2 A:HIS91 2.0 30.4 1.0 OE1 V:GLU190 2.1 17.4 1.0 NE2 V:HIS64 2.3 22.8 1.0 NE2 V:HIS186 2.3 17.5 1.0 CE1 A:HIS91 2.6 30.4 1.0 N1 A:5LD406 2.7 27.9 0.3 CD V:GLU190 2.9 17.4 1.0 CD2 V:HIS64 3.1 22.8 1.0 OE2 V:GLU190 3.2 17.4 1.0 CE1 V:HIS186 3.2 17.5 1.0 C7 A:5LD406 3.3 27.9 0.3 CD2 A:HIS91 3.3 30.4 1.0 CE1 V:HIS64 3.3 22.8 1.0 CD2 V:HIS186 3.3 17.5 1.0 C5 A:5LD406 3.6 27.9 0.3 N2 A:5LD406 3.8 27.9 0.3 ND1 A:HIS91 3.8 30.4 1.0 C6 A:5LD406 3.9 27.9 0.3 CG A:HIS91 4.2 30.4 1.0 CG V:GLU190 4.3 17.4 1.0 CG V:HIS64 4.3 22.8 1.0 C8 A:5LD406 4.3 27.9 0.3 ND1 V:HIS186 4.4 17.5 1.0 ND1 V:HIS64 4.4 22.8 1.0 CG V:HIS186 4.5 17.5 1.0 CB V:GLU190 4.7 17.4 1.0 N4 A:5LD406 4.8 27.9 0.3 C3 A:5LD406 4.9 27.9 0.3

Manganese binding site 9 out of 48 in the Imidazoleglycerol-Phosphate Dehydratase From Saccharomyces Cerevisiae


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 9 of Imidazoleglycerol-Phosphate Dehydratase From Saccharomyces Cerevisiae within 5.0Å range: probe atom residue distance (Å) B Occ B:Mn301 b:27.4 occ:1.00 NE2 B:HIS90 2.1 28.5 1.0 OE1 B:GLU94 2.2 29.4 1.0 NE2 F:HIS187 2.2 16.5 1.0 NE2 B:HIS162 2.3 22.2 1.0 N4 B:5LD305 2.5 47.5 0.3 CE1 B:HIS162 2.5 22.2 1.0 CE1 B:HIS90 2.7 28.5 1.0 CE1 F:HIS187 2.7 16.5 1.0 CD B:GLU94 2.9 29.4 1.0 OE2 B:GLU94 3.2 29.4 1.0 CD2 B:HIS90 3.3 28.5 1.0 CD2 F:HIS187 3.4 16.5 1.0 C3 B:5LD305 3.4 47.5 0.3 CD2 B:HIS162 3.5 22.2 1.0 C5 B:5LD305 3.5 47.5 0.3 ND1 B:HIS162 3.7 22.2 1.0 OD2 F:ASP125 3.7 16.7 1.0 ND1 B:HIS90 3.9 28.5 1.0 ND1 F:HIS187 4.0 16.5 1.0 CG B:GLU94 4.0 29.4 1.0 CG B:HIS162 4.2 22.2 1.0 CG B:HIS90 4.3 28.5 1.0 CG F:HIS187 4.3 16.5 1.0 CB B:GLU94 4.4 29.4 1.0 N2 B:5LD305 4.6 47.5 0.3 CG F:ASP125 4.7 16.7 1.0 N1 B:5LD305 4.7 47.5 0.3 ND2 F:ASN184 4.8 18.2 1.0 CB F:ASP125 4.9 16.7 1.0

Manganese binding site 10 out of 48 in the Imidazoleglycerol-Phosphate Dehydratase From Saccharomyces Cerevisiae


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 10 of Imidazoleglycerol-Phosphate Dehydratase From Saccharomyces Cerevisiae within 5.0Å range: probe atom residue distance (Å) B Occ B:Mn302 b:61.8 occ:0.50 O13 B:5LD303 1.9 47.1 0.3 NE2 N:HIS91 2.0 32.3 1.0 OE1 B:GLU190 2.1 18.7 1.0 NE2 B:HIS64 2.3 24.7 1.0 NE2 B:HIS186 2.3 18.7 1.0 CE1 N:HIS91 2.6 32.3 1.0 N1 B:5LD303 2.7 47.1 0.3 CD B:GLU190 2.9 18.7 1.0 CD2 B:HIS64 3.1 24.7 1.0 OE2 B:GLU190 3.2 18.7 1.0 CE1 B:HIS186 3.2 18.7 1.0 C7 B:5LD303 3.3 47.1 0.3 CD2 N:HIS91 3.3 32.3 1.0 CE1 B:HIS64 3.3 24.7 1.0 CD2 B:HIS186 3.4 18.7 1.0 C5 B:5LD303 3.6 47.1 0.3 N2 B:5LD303 3.8 47.1 0.3 ND1 N:HIS91 3.9 32.3 1.0 C6 B:5LD303 3.9 47.1 0.3 CG N:HIS91 4.2 32.3 1.0 CG B:GLU190 4.3 18.7 1.0 CG B:HIS64 4.3 24.7 1.0 C8 B:5LD303 4.3 47.1 0.3 ND1 B:HIS64 4.4 24.7 1.0 ND1 B:HIS186 4.4 18.7 1.0 CG B:HIS186 4.5 18.7 1.0 CB B:GLU190 4.7 18.7 1.0 N4 B:5LD303 4.8 47.1 0.3 C3 B:5LD303 4.9 47.1 0.3

S.Rawson, C.Bisson, D.L.Hurdiss, A.Fazal, M.J.Mcphillie, S.E.Sedelnikova, P.J.Baker, D.W.Rice, S.P.Muench. Elucidating the Structural Basis For Differing Enzyme Inhibitor Potency By Cryo-Em. Proc. Natl. Acad. Sci. V. 115 1795 2018U.S.A..
ISSN: ESSN 1091-6490
PubMed: 29434040
DOI: 10.1073/PNAS.1708839115