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Atomistry » Manganese » PDB 6dkt-6e4c » 6dq7 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Manganese » PDB 6dkt-6e4c » 6dq7 » |
Manganese in PDB 6dq7: Linked KDM5A Jmj Domain Bound to the Potential Hydrolysis Product of Inhibitor N45 I.E. 3-((6-(4-(2-Cyano-3-Methylbut-2-Enoyl)-1,4- Diazepan-1-Yl)-2-(Pyridin-2-Yl)Pyrimidin-4-Yl)Amino)Propanoic AcidProtein crystallography data
The structure of Linked KDM5A Jmj Domain Bound to the Potential Hydrolysis Product of Inhibitor N45 I.E. 3-((6-(4-(2-Cyano-3-Methylbut-2-Enoyl)-1,4- Diazepan-1-Yl)-2-(Pyridin-2-Yl)Pyrimidin-4-Yl)Amino)Propanoic Acid, PDB code: 6dq7
was solved by
J.R.Horton,
X.Cheng,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Manganese Binding Sites:
The binding sites of Manganese atom in the Linked KDM5A Jmj Domain Bound to the Potential Hydrolysis Product of Inhibitor N45 I.E. 3-((6-(4-(2-Cyano-3-Methylbut-2-Enoyl)-1,4- Diazepan-1-Yl)-2-(Pyridin-2-Yl)Pyrimidin-4-Yl)Amino)Propanoic Acid
(pdb code 6dq7). This binding sites where shown within
5.0 Angstroms radius around Manganese atom.
In total only one binding site of Manganese was determined in the Linked KDM5A Jmj Domain Bound to the Potential Hydrolysis Product of Inhibitor N45 I.E. 3-((6-(4-(2-Cyano-3-Methylbut-2-Enoyl)-1,4- Diazepan-1-Yl)-2-(Pyridin-2-Yl)Pyrimidin-4-Yl)Amino)Propanoic Acid, PDB code: 6dq7: Manganese binding site 1 out of 1 in 6dq7Go back to Manganese Binding Sites List in 6dq7
Manganese binding site 1 out
of 1 in the Linked KDM5A Jmj Domain Bound to the Potential Hydrolysis Product of Inhibitor N45 I.E. 3-((6-(4-(2-Cyano-3-Methylbut-2-Enoyl)-1,4- Diazepan-1-Yl)-2-(Pyridin-2-Yl)Pyrimidin-4-Yl)Amino)Propanoic Acid
Mono view Stereo pair view
Reference:
J.R.Horton,
X.Liu,
C.B.Woodcock,
J.Shanks,
X.Zhang,
G.Rai,
B.Mott,
D.J.Jansen,
S.Kales,
M.J.Henderson,
K.Pohida,
Y.Fang,
X.Hu,
A.Jadhav,
D.Maloney,
M.D.Hall,
A.Simeonov,
H.Fu,
P.M.Vertino,
X.Cheng.
Structure-Based Engineering of Reversible Covalent Inhibitors Against Histone Lysine Demethylase 5A To Be Published.
Page generated: Tue Dec 15 04:51:58 2020
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