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Atomistry » Manganese » PDB 6a9v-6bh4 » 6bh2 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Manganese » PDB 6a9v-6bh4 » 6bh2 » |
Manganese in PDB 6bh2: Linked KDM5A Jmj Domain Bound to the Inhibitor (R)-N-(1-(3-Isopropyl- 1H-Pyrazole-5-Carbonyl)Pyrrolidin-3-Yl)Cyclopropanecarboxamide (Compound N54)Protein crystallography data
The structure of Linked KDM5A Jmj Domain Bound to the Inhibitor (R)-N-(1-(3-Isopropyl- 1H-Pyrazole-5-Carbonyl)Pyrrolidin-3-Yl)Cyclopropanecarboxamide (Compound N54), PDB code: 6bh2
was solved by
J.R.Horton,
X.Cheng,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Manganese Binding Sites:
The binding sites of Manganese atom in the Linked KDM5A Jmj Domain Bound to the Inhibitor (R)-N-(1-(3-Isopropyl- 1H-Pyrazole-5-Carbonyl)Pyrrolidin-3-Yl)Cyclopropanecarboxamide (Compound N54)
(pdb code 6bh2). This binding sites where shown within
5.0 Angstroms radius around Manganese atom.
In total only one binding site of Manganese was determined in the Linked KDM5A Jmj Domain Bound to the Inhibitor (R)-N-(1-(3-Isopropyl- 1H-Pyrazole-5-Carbonyl)Pyrrolidin-3-Yl)Cyclopropanecarboxamide (Compound N54), PDB code: 6bh2: Manganese binding site 1 out of 1 in 6bh2Go back to Manganese Binding Sites List in 6bh2
Manganese binding site 1 out
of 1 in the Linked KDM5A Jmj Domain Bound to the Inhibitor (R)-N-(1-(3-Isopropyl- 1H-Pyrazole-5-Carbonyl)Pyrrolidin-3-Yl)Cyclopropanecarboxamide (Compound N54)
Mono view Stereo pair view
Reference:
J.R.Horton,
X.Liu,
L.Wu,
K.Zhang,
J.Shanks,
X.Zhang,
G.Rai,
B.T.Mott,
D.J.Jansen,
S.C.Kales,
M.J.Henderson,
K.Pohida,
Y.Fang,
X.Hu,
A.Jadhav,
D.J.Maloney,
M.D.Hall,
A.Simeonov,
H.Fu,
P.M.Vertino,
Q.Yan,
X.Cheng.
Insights Into the Action of Inhibitor Enantiomers Against Histone Lysine Demethylase 5A. J. Med. Chem. V. 61 3193 2018.
Page generated: Tue Dec 15 04:50:57 2020
ISSN: ISSN 1520-4804 PubMed: 29537847 DOI: 10.1021/ACS.JMEDCHEM.8B00261 |
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