Manganese in PDB 5w0w: Crystal Structure of Protein Phosphatase 2A Bound to Tiprl

All present enzymatic activity of Crystal Structure of Protein Phosphatase 2A Bound to Tiprl:
3.1.3.16;

The structure of Crystal Structure of Protein Phosphatase 2A Bound to Tiprl, PDB code: 5w0w was solved by C.Wu, A.Zheng, J.Li, K.Satyshur, Y.Xing, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	49.42 / 3.80
Space group	P 32
Cell size a, b, c (Å), α, β, γ (°)	150.983, 150.983, 285.498, 90.00, 90.00, 120.00
R / Rfree (%)	19.7 / 24.6

The binding sites of Manganese atom in the Crystal Structure of Protein Phosphatase 2A Bound to Tiprl (pdb code 5w0w). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total 4 binding sites of Manganese where determined in the Crystal Structure of Protein Phosphatase 2A Bound to Tiprl, PDB code: 5w0w:
Jump to Manganese binding site number: 1; 2; 3; 4;

Manganese binding site 1 out of 4 in the Crystal Structure of Protein Phosphatase 2A Bound to Tiprl


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of Crystal Structure of Protein Phosphatase 2A Bound to Tiprl within 5.0Å range: probe atom residue distance (Å) B Occ C:Mn501 b:0.1 occ:1.00 CE2 C:TYR127 4.1 0.2 1.0 NE2 C:HIS118 4.3 0.7 1.0 OH C:TYR127 4.4 0.6 1.0 CE1 C:HIS118 4.5 0.4 1.0 CZ C:TYR127 4.6 0.8 1.0 CD2 C:TYR127 4.9 0.2 1.0

Manganese binding site 2 out of 4 in the Crystal Structure of Protein Phosphatase 2A Bound to Tiprl


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 2 of Crystal Structure of Protein Phosphatase 2A Bound to Tiprl within 5.0Å range: probe atom residue distance (Å) B Occ F:Mn501 b:0.6 occ:1.00 NE2 F:HIS241 3.5 0.6 1.0 CE1 F:HIS118 3.6 0.3 1.0 OH F:TYR265 3.9 0.3 1.0 NE2 F:HIS118 4.0 0.3 1.0 NH1 F:ARG214 4.1 0.2 1.0 CE1 F:HIS241 4.1 0.2 1.0 CD2 F:HIS241 4.4 0.6 1.0 NH2 F:ARG214 4.4 0.3 1.0 CZ F:ARG214 4.7 0.4 1.0 ND1 F:HIS118 4.8 0.3 1.0

Manganese binding site 3 out of 4 in the Crystal Structure of Protein Phosphatase 2A Bound to Tiprl


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 3 of Crystal Structure of Protein Phosphatase 2A Bound to Tiprl within 5.0Å range: probe atom residue distance (Å) B Occ I:Mn501 b:0.9 occ:1.00 NE2 I:HIS118 3.6 0.3 1.0 CE1 I:HIS118 4.0 0.1 1.0 OH I:TYR127 4.1 0.9 1.0 CZ I:TYR127 4.4 0.6 1.0 CE2 I:TYR127 4.4 0.2 1.0 CD2 I:HIS118 4.8 0.4 1.0 OH I:TYR265 4.9 0.8 1.0

Manganese binding site 4 out of 4 in the Crystal Structure of Protein Phosphatase 2A Bound to Tiprl


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 4 of Crystal Structure of Protein Phosphatase 2A Bound to Tiprl within 5.0Å range: probe atom residue distance (Å) B Occ L:Mn501 b:0.4 occ:1.00 OH L:TYR265 2.8 0.4 1.0 CE1 L:HIS118 3.7 0.6 1.0 CZ L:TYR265 4.1 0.3 1.0 NE2 L:HIS118 4.2 0.7 1.0 CE1 L:HIS241 4.4 0.2 1.0 ND1 L:HIS241 4.6 0.3 1.0 NE2 L:HIS59 4.8 0.2 1.0 CE1 L:TYR265 4.8 0.9 1.0 ND1 L:HIS118 4.8 0.8 1.0 CE1 L:HIS59 4.9 1.0 1.0 CE2 L:TYR265 5.0 0.1 1.0

C.G.Wu, A.Zheng, L.Jiang, M.Rowse, V.Stanevich, H.Chen, Y.Li, K.A.Satyshur, B.Johnson, T.J.Gu, Z.Liu, Y.Xing. Methylation-Regulated Decommissioning of Multimeric PP2A Complexes. Nat Commun V. 8 2272 2017.
ISSN: ESSN 2041-1723
PubMed: 29273778
DOI: 10.1038/S41467-017-02405-3