Manganese in PDB 5vp8: I38T Mutant of 2009 H1N1 Pa Endonuclease

The structure of I38T Mutant of 2009 H1N1 Pa Endonuclease, PDB code: 5vp8 was solved by G.Kumar, S.W.White, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	46.19 / 2.20
Space group	I 4 2 2
Cell size a, b, c (Å), α, β, γ (°)	90.098, 90.098, 134.108, 90.00, 90.00, 90.00
R / Rfree (%)	20 / 23.6

The binding sites of Manganese atom in the I38T Mutant of 2009 H1N1 Pa Endonuclease (pdb code 5vp8). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total only one binding site of Manganese was determined in the I38T Mutant of 2009 H1N1 Pa Endonuclease, PDB code: 5vp8:

Manganese binding site 1 out of 1 in the I38T Mutant of 2009 H1N1 Pa Endonuclease


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of I38T Mutant of 2009 H1N1 Pa Endonuclease within 5.0Å range: probe atom residue distance (Å) B Occ A:Mn201 b:69.8 occ:1.00 O A:ILE120 2.1 54.0 1.0 OD2 A:ASP108 2.3 51.8 1.0 OE2 A:GLU119 2.3 69.4 1.0 O A:HOH313 2.4 60.2 1.0 NE2 A:HIS41 2.4 56.5 1.0 O A:HOH302 2.5 61.4 1.0 CG A:ASP108 3.1 53.7 1.0 CE1 A:HIS41 3.2 52.3 1.0 CD A:GLU119 3.2 70.4 1.0 OD1 A:ASP108 3.2 52.4 1.0 C A:ILE120 3.3 55.2 1.0 CD2 A:HIS41 3.5 53.2 1.0 OE1 A:GLU119 3.6 74.1 1.0 N A:ILE120 3.7 53.8 1.0 CA A:ILE120 4.0 54.1 1.0 ND1 A:HIS41 4.3 54.9 1.0 N A:GLY121 4.4 53.6 1.0 CG A:GLU119 4.5 67.7 1.0 CG A:HIS41 4.5 53.0 1.0 CB A:ILE120 4.5 54.8 1.0 CB A:ASP108 4.5 50.5 1.0 O A:HOH312 4.5 49.0 1.0 C A:GLU119 4.5 55.9 1.0 CA A:GLY121 4.6 51.8 1.0 NZ A:LYS134 4.7 88.2 1.0 CA A:GLU119 4.8 56.4 1.0 CE A:LYS134 4.8 88.9 1.0

J.C.Jones, G.Kumar, S.Barman, I.Najera, S.W.White, R.J.Webby, E.A.Govorkova. Identification of the I38T Pa Substitution As A Resistance Marker For Next-Generation Influenza Virus Endonuclease Inhibitors. Mbio V. 9 2018.
ISSN: ESSN 2150-7511
PubMed: 29691337
DOI: 10.1128/MBIO.00430-18