Manganese in PDB 5ntg: Structure of Leucyl Aminopeptidase From Trypanosoma Cruzi in Complex with Citrate

The structure of Structure of Leucyl Aminopeptidase From Trypanosoma Cruzi in Complex with Citrate, PDB code: 5ntg was solved by J.Timm, K.Wilson, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	57.31 / 2.32
Space group	H 3 2
Cell size a, b, c (Å), α, β, γ (°)	160.120, 160.120, 203.672, 90.00, 90.00, 120.00
R / Rfree (%)	16.6 / 21

The binding sites of Manganese atom in the Structure of Leucyl Aminopeptidase From Trypanosoma Cruzi in Complex with Citrate (pdb code 5ntg). This binding sites where shown within 5.0 Angstroms radius around Manganese atom.
In total 2 binding sites of Manganese where determined in the Structure of Leucyl Aminopeptidase From Trypanosoma Cruzi in Complex with Citrate, PDB code: 5ntg:
Jump to Manganese binding site number: 1; 2;

Manganese binding site 1 out of 2 in the Structure of Leucyl Aminopeptidase From Trypanosoma Cruzi in Complex with Citrate


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 1 of Structure of Leucyl Aminopeptidase From Trypanosoma Cruzi in Complex with Citrate within 5.0Å range: probe atom residue distance (Å) B Occ A:Mn602 b:38.6 occ:1.00 O3 A:CIT601 2.0 51.7 1.0 OD1 A:ASP370 2.0 29.3 1.0 O4 A:CIT601 2.0 44.5 1.0 OE1 A:GLU372 2.0 32.0 1.0 OD2 A:ASP293 2.0 32.5 1.0 O A:ASP370 2.0 28.6 1.0 C5 A:CIT601 2.3 52.1 1.0 CG A:ASP370 3.0 26.4 1.0 CD A:GLU372 3.0 30.6 1.0 CG A:ASP293 3.0 28.0 1.0 C A:ASP370 3.0 25.3 1.0 OE2 A:GLU372 3.3 37.0 1.0 OD1 A:ASP293 3.4 27.9 1.0 CA A:ASP370 3.5 25.4 1.0 O3 A:SO4603 3.7 45.9 1.0 OD2 A:ASP370 3.8 25.2 1.0 CB A:ASP370 3.8 25.5 1.0 C4 A:CIT601 3.8 57.5 1.0 NZ A:LYS300 3.9 27.2 1.0 CE A:LYS300 4.2 27.3 1.0 N A:ALA371 4.2 25.9 1.0 N A:GLU372 4.3 27.9 1.0 CB A:ASP293 4.4 29.0 1.0 CG A:GLU372 4.4 29.3 1.0 OD2 A:ASP311 4.5 47.3 1.0 ND2 A:ASN343 4.5 24.5 1.0 O A:HOH874 4.7 44.6 1.0 CA A:ALA371 4.7 27.1 1.0 O7 A:CIT601 4.7 62.9 1.0 C3 A:CIT601 4.8 60.9 1.0 CB A:GLU372 4.9 28.3 1.0 N A:ASP370 4.9 24.5 1.0

Manganese binding site 2 out of 2 in the Structure of Leucyl Aminopeptidase From Trypanosoma Cruzi in Complex with Citrate


Mono view


Stereo pair view

A full contact list of Manganese with other atoms in the Mn binding site number 2 of Structure of Leucyl Aminopeptidase From Trypanosoma Cruzi in Complex with Citrate within 5.0Å range: probe atom residue distance (Å) B Occ B:Mn603 b:43.0 occ:1.00 OD2 B:ASP293 1.9 34.8 1.0 OE2 B:GLU372 1.9 36.1 1.0 O3 B:CIT602 2.0 50.6 1.0 O4 B:CIT602 2.0 49.0 1.0 OD1 B:ASP370 2.0 31.8 1.0 O B:ASP370 2.0 31.9 1.0 C5 B:CIT602 2.2 56.4 1.0 CG B:ASP293 3.0 30.0 1.0 CD B:GLU372 3.0 35.1 1.0 CG B:ASP370 3.0 27.8 1.0 C B:ASP370 3.0 26.9 1.0 OD1 B:ASP293 3.3 28.3 1.0 OE1 B:GLU372 3.3 39.3 1.0 CA B:ASP370 3.6 26.3 1.0 C4 B:CIT602 3.6 65.0 1.0 O1 B:SO4604 3.7 38.5 1.0 OD2 B:ASP370 3.8 28.9 1.0 CB B:ASP370 3.9 26.6 1.0 NZ B:LYS300 3.9 31.5 1.0 CE B:LYS300 4.2 29.5 1.0 N B:ALA371 4.2 27.5 1.0 N B:GLU372 4.3 29.4 1.0 CB B:ASP293 4.3 29.7 1.0 CG B:GLU372 4.4 34.4 1.0 OD2 B:ASP311 4.5 54.2 1.0 ND2 B:ASN343 4.5 29.3 1.0 CA B:ALA371 4.7 28.8 1.0 CB B:GLU372 4.8 32.1 1.0 C6 B:CIT602 4.9 75.8 1.0 N B:ASP370 4.9 25.4 1.0 C3 B:CIT602 4.9 68.2 1.0

J.Timm, M.Valente, D.Garcia-Caballero, K.S.Wilson, D.Gonzalez-Pacanowska. Structural Characterization of Acidic M17 Leucine Aminopeptidases From the Tritryps and Evaluation of Their Role in Nutrient Starvation Intrypanosoma Brucei. Msphere V. 2 2017.
ISSN: ESSN 2379-5042
PubMed: 28815215
DOI: 10.1128/MSPHERE.00226-17