Manganese in PDB 5ntd: Structure of Leucyl Aminopeptidase From Trypanosoma Brucei in Complex with Bestatin
Protein crystallography data
The structure of Structure of Leucyl Aminopeptidase From Trypanosoma Brucei in Complex with Bestatin, PDB code: 5ntd
was solved by
J.Timm,
K.Wilson,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
|
Resolution Low / High (Å)
|
80.33 /
2.30
|
|
Space group
|
P 1 21 1
|
|
Cell size a, b, c (Å), α, β, γ (°)
|
87.260,
143.450,
268.030,
90.00,
95.54,
90.00
|
|
R / Rfree (%)
|
18.9 /
21.4
|
Manganese Binding Sites:
Pages:
>>> Page 1 <<<
Page 2, Binding sites: 11 -
20;
Page 3, Binding sites: 21 -
24;
Binding sites:
The binding sites of Manganese atom in the Structure of Leucyl Aminopeptidase From Trypanosoma Brucei in Complex with Bestatin
(pdb code 5ntd). This binding sites where shown within
5.0 Angstroms radius around Manganese atom.
In total 24 binding sites of Manganese where determined in the
Structure of Leucyl Aminopeptidase From Trypanosoma Brucei in Complex with Bestatin, PDB code: 5ntd:
Jump to Manganese binding site number:
1;
2;
3;
4;
5;
6;
7;
8;
9;
10;
Manganese binding site 1 out
of 24 in 5ntd
Go back to
Manganese Binding Sites List in 5ntd
Manganese binding site 1 out
of 24 in the Structure of Leucyl Aminopeptidase From Trypanosoma Brucei in Complex with Bestatin
 Mono view
 Stereo pair view
|
|
A full contact list of Manganese with other atoms in the Mn binding
site number 1 of Structure of Leucyl Aminopeptidase From Trypanosoma Brucei in Complex with Bestatin within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Mn603
b:31.5
occ:1.00
|
OD1
|
A:ASP371
|
2.0
|
28.1
|
1.0
|
|
O3
|
A:BES605
|
2.0
|
34.8
|
1.0
|
|
O2
|
A:BES605
|
2.0
|
34.9
|
1.0
|
|
O
|
A:ASP371
|
2.0
|
28.8
|
1.0
|
|
OE2
|
A:GLU373
|
2.0
|
25.0
|
1.0
|
|
OD2
|
A:ASP294
|
2.0
|
29.7
|
1.0
|
|
C3
|
A:BES605
|
2.8
|
35.9
|
1.0
|
|
CG
|
A:ASP294
|
2.9
|
24.7
|
1.0
|
|
C2
|
A:BES605
|
2.9
|
34.4
|
1.0
|
|
CD
|
A:GLU373
|
3.0
|
23.1
|
1.0
|
|
CG
|
A:ASP371
|
3.0
|
25.6
|
1.0
|
|
C
|
A:ASP371
|
3.0
|
24.6
|
1.0
|
|
OD1
|
A:ASP294
|
3.1
|
23.6
|
1.0
|
|
MN
|
A:MN604
|
3.2
|
27.0
|
1.0
|
|
OE1
|
A:GLU373
|
3.3
|
22.8
|
1.0
|
|
CA
|
A:ASP371
|
3.5
|
24.2
|
1.0
|
|
C1
|
A:BES605
|
3.8
|
33.4
|
1.0
|
|
CB
|
A:ASP371
|
3.8
|
24.6
|
1.0
|
|
NZ
|
A:LYS301
|
3.9
|
27.5
|
1.0
|
|
OD2
|
A:ASP371
|
3.9
|
26.8
|
1.0
|
|
N2
|
A:BES605
|
3.9
|
30.7
|
1.0
|
|
N1
|
A:BES605
|
4.0
|
37.3
|
1.0
|
|
CE
|
A:LYS301
|
4.1
|
27.4
|
1.0
|
|
O1
|
A:BCT606
|
4.1
|
41.8
|
1.0
|
|
N
|
A:ALA372
|
4.2
|
25.3
|
1.0
|
|
CB
|
A:ASP294
|
4.4
|
25.5
|
1.0
|
|
CG
|
A:GLU373
|
4.4
|
24.2
|
1.0
|
|
N
|
A:GLU373
|
4.4
|
25.6
|
1.0
|
|
ND2
|
A:ASN344
|
4.5
|
21.9
|
1.0
|
|
CA
|
A:ALA372
|
4.7
|
27.1
|
1.0
|
|
NZ
|
A:LYS289
|
4.8
|
27.4
|
1.0
|
|
C4
|
A:BES605
|
4.8
|
42.2
|
1.0
|
|
OD2
|
A:ASP312
|
4.8
|
26.0
|
1.0
|
|
CA
|
A:GLY296
|
4.9
|
23.9
|
1.0
|
|
CB
|
A:GLU373
|
4.9
|
24.3
|
1.0
|
|
N
|
A:ASP371
|
4.9
|
22.6
|
1.0
|
|
C
|
A:BCT606
|
5.0
|
43.3
|
1.0
|
|
Manganese binding site 2 out
of 24 in 5ntd
Go back to
Manganese Binding Sites List in 5ntd
Manganese binding site 2 out
of 24 in the Structure of Leucyl Aminopeptidase From Trypanosoma Brucei in Complex with Bestatin
 Mono view
 Stereo pair view
|
|
A full contact list of Manganese with other atoms in the Mn binding
site number 2 of Structure of Leucyl Aminopeptidase From Trypanosoma Brucei in Complex with Bestatin within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:Mn604
b:27.0
occ:1.00
|
OE1
|
A:GLU373
|
1.9
|
22.8
|
1.0
|
|
OD2
|
A:ASP312
|
1.9
|
26.0
|
1.0
|
|
O2
|
A:BES605
|
2.0
|
34.9
|
1.0
|
|
N2
|
A:BES605
|
2.0
|
30.7
|
1.0
|
|
OD2
|
A:ASP294
|
2.0
|
29.7
|
1.0
|
|
NZ
|
A:LYS289
|
2.0
|
27.4
|
1.0
|
|
CG
|
A:ASP312
|
2.9
|
23.4
|
1.0
|
|
CD
|
A:GLU373
|
3.0
|
23.1
|
1.0
|
|
C2
|
A:BES605
|
3.0
|
34.4
|
1.0
|
|
CG
|
A:ASP294
|
3.0
|
24.7
|
1.0
|
|
CE
|
A:LYS289
|
3.0
|
26.5
|
1.0
|
|
C1
|
A:BES605
|
3.1
|
33.4
|
1.0
|
|
OD1
|
A:ASP312
|
3.2
|
23.0
|
1.0
|
|
MN
|
A:MN603
|
3.2
|
31.5
|
1.0
|
|
OE2
|
A:GLU373
|
3.3
|
25.0
|
1.0
|
|
CB
|
A:ASP294
|
3.6
|
25.5
|
1.0
|
|
O1
|
A:BCT606
|
4.0
|
41.8
|
1.0
|
|
OD1
|
A:ASP294
|
4.0
|
23.6
|
1.0
|
|
C3
|
A:BES605
|
4.2
|
35.9
|
1.0
|
|
O3
|
A:BES605
|
4.2
|
34.8
|
1.0
|
|
CB
|
A:ASP312
|
4.3
|
24.8
|
1.0
|
|
CG
|
A:GLU373
|
4.3
|
24.2
|
1.0
|
|
O
|
A:THR401
|
4.3
|
24.2
|
1.0
|
|
C6
|
A:BES605
|
4.4
|
34.9
|
1.0
|
|
CD
|
A:LYS289
|
4.5
|
26.4
|
1.0
|
|
CG2
|
A:ILE291
|
4.7
|
23.4
|
1.0
|
|
O
|
A:ASP371
|
4.7
|
28.8
|
1.0
|
|
CB
|
A:ILE291
|
4.8
|
24.0
|
1.0
|
|
CG1
|
A:ILE291
|
4.9
|
23.4
|
1.0
|
|
OD1
|
A:ASP371
|
4.9
|
28.1
|
1.0
|
|
Manganese binding site 3 out
of 24 in 5ntd
Go back to
Manganese Binding Sites List in 5ntd
Manganese binding site 3 out
of 24 in the Structure of Leucyl Aminopeptidase From Trypanosoma Brucei in Complex with Bestatin
 Mono view
 Stereo pair view
|
|
A full contact list of Manganese with other atoms in the Mn binding
site number 3 of Structure of Leucyl Aminopeptidase From Trypanosoma Brucei in Complex with Bestatin within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:Mn602
b:33.2
occ:1.00
|
O3
|
B:BES604
|
1.9
|
37.2
|
1.0
|
|
OD1
|
B:ASP371
|
2.0
|
29.1
|
1.0
|
|
O
|
B:ASP371
|
2.0
|
30.3
|
1.0
|
|
OE1
|
B:GLU373
|
2.0
|
25.3
|
1.0
|
|
O2
|
B:BES604
|
2.0
|
37.7
|
1.0
|
|
OD2
|
B:ASP294
|
2.0
|
30.8
|
1.0
|
|
C3
|
B:BES604
|
2.7
|
37.4
|
1.0
|
|
CG
|
B:ASP294
|
2.9
|
26.0
|
1.0
|
|
C2
|
B:BES604
|
2.9
|
36.2
|
1.0
|
|
CD
|
B:GLU373
|
3.0
|
23.3
|
1.0
|
|
C
|
B:ASP371
|
3.0
|
27.5
|
1.0
|
|
OD1
|
B:ASP294
|
3.0
|
24.2
|
1.0
|
|
CG
|
B:ASP371
|
3.0
|
26.8
|
1.0
|
|
MN
|
B:MN603
|
3.2
|
29.4
|
1.0
|
|
OE2
|
B:GLU373
|
3.3
|
24.7
|
1.0
|
|
CA
|
B:ASP371
|
3.5
|
27.2
|
1.0
|
|
CB
|
B:ASP371
|
3.8
|
27.4
|
1.0
|
|
C1
|
B:BES604
|
3.8
|
34.9
|
1.0
|
|
OD2
|
B:ASP371
|
3.9
|
27.3
|
1.0
|
|
NZ
|
B:LYS301
|
3.9
|
29.6
|
1.0
|
|
N1
|
B:BES604
|
4.0
|
40.3
|
1.0
|
|
N2
|
B:BES604
|
4.1
|
34.2
|
1.0
|
|
CE
|
B:LYS301
|
4.1
|
30.0
|
1.0
|
|
O3
|
B:BCT605
|
4.2
|
37.9
|
1.0
|
|
N
|
B:ALA372
|
4.2
|
26.1
|
1.0
|
|
CG
|
B:GLU373
|
4.3
|
23.9
|
1.0
|
|
CB
|
B:ASP294
|
4.3
|
28.1
|
1.0
|
|
N
|
B:GLU373
|
4.4
|
24.8
|
1.0
|
|
ND2
|
B:ASN344
|
4.5
|
28.2
|
1.0
|
|
CA
|
B:ALA372
|
4.7
|
25.9
|
1.0
|
|
C4
|
B:BES604
|
4.8
|
43.3
|
1.0
|
|
NZ
|
B:LYS289
|
4.8
|
29.2
|
1.0
|
|
OD2
|
B:ASP312
|
4.8
|
28.6
|
1.0
|
|
CB
|
B:GLU373
|
4.8
|
24.2
|
1.0
|
|
CA
|
B:GLY296
|
4.9
|
26.4
|
1.0
|
|
N
|
B:ASP371
|
4.9
|
27.1
|
1.0
|
|
C13
|
B:BES604
|
4.9
|
43.4
|
1.0
|
|
Manganese binding site 4 out
of 24 in 5ntd
Go back to
Manganese Binding Sites List in 5ntd
Manganese binding site 4 out
of 24 in the Structure of Leucyl Aminopeptidase From Trypanosoma Brucei in Complex with Bestatin
 Mono view
 Stereo pair view
|
|
A full contact list of Manganese with other atoms in the Mn binding
site number 4 of Structure of Leucyl Aminopeptidase From Trypanosoma Brucei in Complex with Bestatin within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:Mn603
b:29.4
occ:1.00
|
O2
|
B:BES604
|
1.9
|
37.7
|
1.0
|
|
OE2
|
B:GLU373
|
1.9
|
24.7
|
1.0
|
|
OD2
|
B:ASP312
|
1.9
|
28.6
|
1.0
|
|
NZ
|
B:LYS289
|
2.0
|
29.2
|
1.0
|
|
N2
|
B:BES604
|
2.0
|
34.2
|
1.0
|
|
OD2
|
B:ASP294
|
2.0
|
30.8
|
1.0
|
|
C2
|
B:BES604
|
2.9
|
36.2
|
1.0
|
|
CG
|
B:ASP312
|
2.9
|
27.0
|
1.0
|
|
CD
|
B:GLU373
|
3.0
|
23.3
|
1.0
|
|
CE
|
B:LYS289
|
3.0
|
27.7
|
1.0
|
|
C1
|
B:BES604
|
3.0
|
34.9
|
1.0
|
|
CG
|
B:ASP294
|
3.0
|
26.0
|
1.0
|
|
OD1
|
B:ASP312
|
3.2
|
25.4
|
1.0
|
|
MN
|
B:MN602
|
3.2
|
33.2
|
1.0
|
|
OE1
|
B:GLU373
|
3.4
|
25.3
|
1.0
|
|
CB
|
B:ASP294
|
3.6
|
28.1
|
1.0
|
|
O3
|
B:BCT605
|
4.0
|
37.9
|
1.0
|
|
OD1
|
B:ASP294
|
4.1
|
24.2
|
1.0
|
|
C3
|
B:BES604
|
4.1
|
37.4
|
1.0
|
|
O3
|
B:BES604
|
4.1
|
37.2
|
1.0
|
|
CB
|
B:ASP312
|
4.3
|
28.2
|
1.0
|
|
O
|
B:THR401
|
4.3
|
25.8
|
1.0
|
|
C6
|
B:BES604
|
4.3
|
34.9
|
1.0
|
|
CG
|
B:GLU373
|
4.3
|
23.9
|
1.0
|
|
CD
|
B:LYS289
|
4.5
|
27.8
|
1.0
|
|
O
|
B:ASP371
|
4.7
|
30.3
|
1.0
|
|
CG2
|
B:ILE291
|
4.7
|
26.4
|
1.0
|
|
CB
|
B:ILE291
|
4.8
|
27.9
|
1.0
|
|
CG1
|
B:ILE291
|
4.9
|
27.7
|
1.0
|
|
OD1
|
B:ASP371
|
4.9
|
29.1
|
1.0
|
|
N
|
B:GLY374
|
5.0
|
23.5
|
1.0
|
|
Manganese binding site 5 out
of 24 in 5ntd
Go back to
Manganese Binding Sites List in 5ntd
Manganese binding site 5 out
of 24 in the Structure of Leucyl Aminopeptidase From Trypanosoma Brucei in Complex with Bestatin
 Mono view
 Stereo pair view
|
|
A full contact list of Manganese with other atoms in the Mn binding
site number 5 of Structure of Leucyl Aminopeptidase From Trypanosoma Brucei in Complex with Bestatin within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
D:Mn602
b:31.9
occ:1.00
|
O3
|
D:BES604
|
2.0
|
34.7
|
1.0
|
|
O2
|
D:BES604
|
2.0
|
34.9
|
1.0
|
|
OE2
|
D:GLU373
|
2.0
|
25.3
|
1.0
|
|
O
|
D:ASP371
|
2.0
|
29.6
|
1.0
|
|
OD2
|
D:ASP294
|
2.0
|
30.5
|
1.0
|
|
OD1
|
D:ASP371
|
2.0
|
31.3
|
1.0
|
|
C3
|
D:BES604
|
2.8
|
35.5
|
1.0
|
|
C2
|
D:BES604
|
2.9
|
33.6
|
1.0
|
|
CG
|
D:ASP294
|
2.9
|
26.9
|
1.0
|
|
CD
|
D:GLU373
|
3.0
|
25.2
|
1.0
|
|
C
|
D:ASP371
|
3.0
|
26.4
|
1.0
|
|
CG
|
D:ASP371
|
3.1
|
27.9
|
1.0
|
|
OD1
|
D:ASP294
|
3.1
|
26.2
|
1.0
|
|
MN
|
D:MN603
|
3.2
|
28.8
|
1.0
|
|
OE1
|
D:GLU373
|
3.3
|
26.2
|
1.0
|
|
CA
|
D:ASP371
|
3.6
|
27.4
|
1.0
|
|
C1
|
D:BES604
|
3.8
|
32.9
|
1.0
|
|
CB
|
D:ASP371
|
3.9
|
27.3
|
1.0
|
|
N2
|
D:BES604
|
3.9
|
32.2
|
1.0
|
|
NZ
|
D:LYS301
|
3.9
|
26.9
|
1.0
|
|
OD2
|
D:ASP371
|
3.9
|
27.5
|
1.0
|
|
N1
|
D:BES604
|
4.0
|
38.5
|
1.0
|
|
O2
|
D:BCT605
|
4.1
|
39.6
|
1.0
|
|
CE
|
D:LYS301
|
4.1
|
27.2
|
1.0
|
|
N
|
D:ALA372
|
4.2
|
25.9
|
1.0
|
|
CB
|
D:ASP294
|
4.3
|
27.5
|
1.0
|
|
CG
|
D:GLU373
|
4.4
|
26.1
|
1.0
|
|
N
|
D:GLU373
|
4.4
|
24.8
|
1.0
|
|
ND2
|
D:ASN344
|
4.5
|
25.2
|
1.0
|
|
CA
|
D:ALA372
|
4.7
|
25.5
|
1.0
|
|
NZ
|
D:LYS289
|
4.7
|
28.1
|
1.0
|
|
OD2
|
D:ASP312
|
4.8
|
26.4
|
1.0
|
|
C4
|
D:BES604
|
4.9
|
42.0
|
1.0
|
|
CB
|
D:GLU373
|
4.9
|
26.1
|
1.0
|
|
CA
|
D:GLY296
|
5.0
|
25.6
|
1.0
|
|
N
|
D:ASP371
|
5.0
|
26.2
|
1.0
|
|
Manganese binding site 6 out
of 24 in 5ntd
Go back to
Manganese Binding Sites List in 5ntd
Manganese binding site 6 out
of 24 in the Structure of Leucyl Aminopeptidase From Trypanosoma Brucei in Complex with Bestatin
 Mono view
 Stereo pair view
|
|
A full contact list of Manganese with other atoms in the Mn binding
site number 6 of Structure of Leucyl Aminopeptidase From Trypanosoma Brucei in Complex with Bestatin within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
D:Mn603
b:28.8
occ:1.00
|
OE1
|
D:GLU373
|
1.9
|
26.2
|
1.0
|
|
O2
|
D:BES604
|
1.9
|
34.9
|
1.0
|
|
OD2
|
D:ASP312
|
2.0
|
26.4
|
1.0
|
|
NZ
|
D:LYS289
|
2.0
|
28.1
|
1.0
|
|
N2
|
D:BES604
|
2.0
|
32.2
|
1.0
|
|
OD2
|
D:ASP294
|
2.0
|
30.5
|
1.0
|
|
CG
|
D:ASP312
|
2.9
|
23.8
|
1.0
|
|
CD
|
D:GLU373
|
3.0
|
25.2
|
1.0
|
|
C2
|
D:BES604
|
3.0
|
33.6
|
1.0
|
|
CE
|
D:LYS289
|
3.0
|
26.1
|
1.0
|
|
CG
|
D:ASP294
|
3.0
|
26.9
|
1.0
|
|
C1
|
D:BES604
|
3.1
|
32.9
|
1.0
|
|
MN
|
D:MN602
|
3.2
|
31.9
|
1.0
|
|
OD1
|
D:ASP312
|
3.2
|
24.9
|
1.0
|
|
OE2
|
D:GLU373
|
3.3
|
25.3
|
1.0
|
|
CB
|
D:ASP294
|
3.6
|
27.5
|
1.0
|
|
O2
|
D:BCT605
|
4.0
|
39.6
|
1.0
|
|
OD1
|
D:ASP294
|
4.0
|
26.2
|
1.0
|
|
CE
|
D:MET309
|
4.1
|
37.7
|
1.0
|
|
C3
|
D:BES604
|
4.1
|
35.5
|
1.0
|
|
O3
|
D:BES604
|
4.2
|
34.7
|
1.0
|
|
O
|
D:THR401
|
4.3
|
26.5
|
1.0
|
|
CG
|
D:GLU373
|
4.3
|
26.1
|
1.0
|
|
CB
|
D:ASP312
|
4.3
|
25.4
|
1.0
|
|
C6
|
D:BES604
|
4.4
|
33.3
|
1.0
|
|
CD
|
D:LYS289
|
4.4
|
26.4
|
1.0
|
|
O
|
D:ASP371
|
4.7
|
29.6
|
1.0
|
|
CG2
|
D:ILE291
|
4.7
|
25.4
|
1.0
|
|
CB
|
D:ILE291
|
4.8
|
25.8
|
1.0
|
|
CG1
|
D:ILE291
|
4.8
|
25.1
|
1.0
|
|
OD1
|
D:ASP371
|
4.9
|
31.3
|
1.0
|
|
N
|
D:GLY374
|
5.0
|
26.5
|
1.0
|
|
Manganese binding site 7 out
of 24 in 5ntd
Go back to
Manganese Binding Sites List in 5ntd
Manganese binding site 7 out
of 24 in the Structure of Leucyl Aminopeptidase From Trypanosoma Brucei in Complex with Bestatin
 Mono view
 Stereo pair view
|
|
A full contact list of Manganese with other atoms in the Mn binding
site number 7 of Structure of Leucyl Aminopeptidase From Trypanosoma Brucei in Complex with Bestatin within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
C:Mn602
b:39.7
occ:1.00
|
O3
|
C:BES604
|
1.9
|
40.0
|
1.0
|
|
OD1
|
C:ASP371
|
2.0
|
35.3
|
1.0
|
|
O
|
C:ASP371
|
2.0
|
34.0
|
1.0
|
|
O2
|
C:BES604
|
2.0
|
38.7
|
1.0
|
|
OE2
|
C:GLU373
|
2.0
|
33.1
|
1.0
|
|
OD2
|
C:ASP294
|
2.0
|
38.2
|
1.0
|
|
C3
|
C:BES604
|
2.7
|
40.4
|
1.0
|
|
CG
|
C:ASP294
|
2.9
|
31.6
|
1.0
|
|
C2
|
C:BES604
|
2.9
|
38.6
|
1.0
|
|
C
|
C:ASP371
|
3.0
|
31.6
|
1.0
|
|
CD
|
C:GLU373
|
3.0
|
29.6
|
1.0
|
|
CG
|
C:ASP371
|
3.0
|
31.1
|
1.0
|
|
OD1
|
C:ASP294
|
3.1
|
30.4
|
1.0
|
|
MN
|
C:MN603
|
3.2
|
32.6
|
1.0
|
|
OE1
|
C:GLU373
|
3.3
|
31.3
|
1.0
|
|
CA
|
C:ASP371
|
3.5
|
33.0
|
1.0
|
|
C1
|
C:BES604
|
3.8
|
38.8
|
1.0
|
|
CB
|
C:ASP371
|
3.8
|
32.3
|
1.0
|
|
NZ
|
C:LYS301
|
3.9
|
30.6
|
1.0
|
|
OD2
|
C:ASP371
|
3.9
|
29.4
|
1.0
|
|
N1
|
C:BES604
|
4.0
|
41.8
|
1.0
|
|
N2
|
C:BES604
|
4.0
|
37.9
|
1.0
|
|
CE
|
C:LYS301
|
4.1
|
31.3
|
1.0
|
|
N
|
C:ALA372
|
4.2
|
32.6
|
1.0
|
|
O3
|
C:BCT605
|
4.3
|
39.1
|
1.0
|
|
CB
|
C:ASP294
|
4.4
|
30.4
|
1.0
|
|
CG
|
C:GLU373
|
4.4
|
31.1
|
1.0
|
|
N
|
C:GLU373
|
4.4
|
30.9
|
1.0
|
|
ND2
|
C:ASN344
|
4.5
|
27.8
|
1.0
|
|
CA
|
C:ALA372
|
4.7
|
32.6
|
1.0
|
|
NZ
|
C:LYS289
|
4.8
|
32.2
|
1.0
|
|
OD2
|
C:ASP312
|
4.8
|
32.2
|
1.0
|
|
C4
|
C:BES604
|
4.8
|
46.1
|
1.0
|
|
CB
|
C:GLU373
|
4.9
|
29.6
|
1.0
|
|
CA
|
C:GLY296
|
4.9
|
27.6
|
1.0
|
|
N
|
C:ASP371
|
4.9
|
33.0
|
1.0
|
|
Manganese binding site 8 out
of 24 in 5ntd
Go back to
Manganese Binding Sites List in 5ntd
Manganese binding site 8 out
of 24 in the Structure of Leucyl Aminopeptidase From Trypanosoma Brucei in Complex with Bestatin
 Mono view
 Stereo pair view
|
|
A full contact list of Manganese with other atoms in the Mn binding
site number 8 of Structure of Leucyl Aminopeptidase From Trypanosoma Brucei in Complex with Bestatin within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
C:Mn603
b:32.6
occ:1.00
|
OE1
|
C:GLU373
|
1.9
|
31.3
|
1.0
|
|
OD2
|
C:ASP312
|
1.9
|
32.2
|
1.0
|
|
O2
|
C:BES604
|
1.9
|
38.7
|
1.0
|
|
N2
|
C:BES604
|
2.0
|
37.9
|
1.0
|
|
NZ
|
C:LYS289
|
2.0
|
32.2
|
1.0
|
|
OD2
|
C:ASP294
|
2.0
|
38.2
|
1.0
|
|
C2
|
C:BES604
|
2.9
|
38.6
|
1.0
|
|
CG
|
C:ASP312
|
2.9
|
27.9
|
1.0
|
|
CD
|
C:GLU373
|
3.0
|
29.6
|
1.0
|
|
C1
|
C:BES604
|
3.0
|
38.8
|
1.0
|
|
CG
|
C:ASP294
|
3.0
|
31.6
|
1.0
|
|
CE
|
C:LYS289
|
3.0
|
31.0
|
1.0
|
|
OD1
|
C:ASP312
|
3.2
|
27.8
|
1.0
|
|
MN
|
C:MN602
|
3.2
|
39.7
|
1.0
|
|
OE2
|
C:GLU373
|
3.3
|
33.1
|
1.0
|
|
CB
|
C:ASP294
|
3.6
|
30.4
|
1.0
|
|
OD1
|
C:ASP294
|
4.0
|
30.4
|
1.0
|
|
C3
|
C:BES604
|
4.1
|
40.4
|
1.0
|
|
O3
|
C:BCT605
|
4.1
|
39.1
|
1.0
|
|
O3
|
C:BES604
|
4.1
|
40.0
|
1.0
|
|
C6
|
C:BES604
|
4.3
|
40.4
|
1.0
|
|
CB
|
C:ASP312
|
4.3
|
28.1
|
1.0
|
|
O
|
C:THR401
|
4.3
|
28.5
|
1.0
|
|
CG
|
C:GLU373
|
4.3
|
31.1
|
1.0
|
|
CD
|
C:LYS289
|
4.5
|
31.8
|
1.0
|
|
O
|
C:ASP371
|
4.7
|
34.0
|
1.0
|
|
CG2
|
C:ILE291
|
4.7
|
29.4
|
1.0
|
|
CB
|
C:ILE291
|
4.8
|
30.4
|
1.0
|
|
CG1
|
C:ILE291
|
4.9
|
29.4
|
1.0
|
|
OD1
|
C:ASP371
|
4.9
|
35.3
|
1.0
|
|
N
|
C:GLY374
|
5.0
|
30.3
|
1.0
|
|
Manganese binding site 9 out
of 24 in 5ntd
Go back to
Manganese Binding Sites List in 5ntd
Manganese binding site 9 out
of 24 in the Structure of Leucyl Aminopeptidase From Trypanosoma Brucei in Complex with Bestatin
 Mono view
 Stereo pair view
|
|
A full contact list of Manganese with other atoms in the Mn binding
site number 9 of Structure of Leucyl Aminopeptidase From Trypanosoma Brucei in Complex with Bestatin within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
E:Mn602
b:35.5
occ:1.00
|
O3
|
E:BES604
|
2.0
|
38.6
|
1.0
|
|
O2
|
E:BES604
|
2.0
|
37.6
|
1.0
|
|
OD1
|
E:ASP371
|
2.0
|
31.5
|
1.0
|
|
OD2
|
E:ASP294
|
2.0
|
33.8
|
1.0
|
|
O
|
E:ASP371
|
2.0
|
33.5
|
1.0
|
|
OE1
|
E:GLU373
|
2.0
|
31.9
|
1.0
|
|
C3
|
E:BES604
|
2.8
|
39.2
|
1.0
|
|
CG
|
E:ASP294
|
2.9
|
29.2
|
1.0
|
|
C2
|
E:BES604
|
2.9
|
38.8
|
1.0
|
|
CD
|
E:GLU373
|
3.0
|
30.0
|
1.0
|
|
C
|
E:ASP371
|
3.0
|
27.9
|
1.0
|
|
CG
|
E:ASP371
|
3.0
|
28.8
|
1.0
|
|
OD1
|
E:ASP294
|
3.0
|
29.1
|
1.0
|
|
MN
|
E:MN603
|
3.2
|
32.3
|
1.0
|
|
OE2
|
E:GLU373
|
3.3
|
32.7
|
1.0
|
|
CA
|
E:ASP371
|
3.5
|
28.6
|
1.0
|
|
C1
|
E:BES604
|
3.8
|
39.5
|
1.0
|
|
CB
|
E:ASP371
|
3.8
|
28.6
|
1.0
|
|
NZ
|
E:LYS301
|
3.9
|
35.0
|
1.0
|
|
OD2
|
E:ASP371
|
3.9
|
26.4
|
1.0
|
|
N2
|
E:BES604
|
4.0
|
38.7
|
1.0
|
|
N1
|
E:BES604
|
4.0
|
42.5
|
1.0
|
|
O3
|
E:BCT605
|
4.1
|
36.2
|
1.0
|
|
CE
|
E:LYS301
|
4.1
|
33.1
|
1.0
|
|
N
|
E:ALA372
|
4.2
|
27.8
|
1.0
|
|
CB
|
E:ASP294
|
4.3
|
29.8
|
1.0
|
|
CG
|
E:GLU373
|
4.3
|
30.4
|
1.0
|
|
N
|
E:GLU373
|
4.4
|
28.2
|
1.0
|
|
ND2
|
E:ASN344
|
4.5
|
29.5
|
1.0
|
|
CA
|
E:ALA372
|
4.7
|
28.0
|
1.0
|
|
NZ
|
E:LYS289
|
4.7
|
29.7
|
1.0
|
|
OD2
|
E:ASP312
|
4.8
|
32.0
|
1.0
|
|
C4
|
E:BES604
|
4.8
|
48.8
|
1.0
|
|
CB
|
E:GLU373
|
4.9
|
29.2
|
1.0
|
|
CA
|
E:GLY296
|
4.9
|
28.9
|
1.0
|
|
N
|
E:ASP371
|
4.9
|
28.4
|
1.0
|
|
Manganese binding site 10 out
of 24 in 5ntd
Go back to
Manganese Binding Sites List in 5ntd
Manganese binding site 10 out
of 24 in the Structure of Leucyl Aminopeptidase From Trypanosoma Brucei in Complex with Bestatin
 Mono view
 Stereo pair view
|
|
A full contact list of Manganese with other atoms in the Mn binding
site number 10 of Structure of Leucyl Aminopeptidase From Trypanosoma Brucei in Complex with Bestatin within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
E:Mn603
b:32.3
occ:1.00
|
OE2
|
E:GLU373
|
1.9
|
32.7
|
1.0
|
|
O2
|
E:BES604
|
1.9
|
37.6
|
1.0
|
|
OD2
|
E:ASP312
|
2.0
|
32.0
|
1.0
|
|
NZ
|
E:LYS289
|
2.0
|
29.7
|
1.0
|
|
OD2
|
E:ASP294
|
2.0
|
33.8
|
1.0
|
|
N2
|
E:BES604
|
2.0
|
38.7
|
1.0
|
|
C2
|
E:BES604
|
2.9
|
38.8
|
1.0
|
|
CG
|
E:ASP312
|
2.9
|
28.6
|
1.0
|
|
CD
|
E:GLU373
|
3.0
|
30.0
|
1.0
|
|
C1
|
E:BES604
|
3.0
|
39.5
|
1.0
|
|
CG
|
E:ASP294
|
3.0
|
29.2
|
1.0
|
|
CE
|
E:LYS289
|
3.0
|
27.6
|
1.0
|
|
MN
|
E:MN602
|
3.2
|
35.5
|
1.0
|
|
OD1
|
E:ASP312
|
3.2
|
28.1
|
1.0
|
|
OE1
|
E:GLU373
|
3.3
|
31.9
|
1.0
|
|
CB
|
E:ASP294
|
3.6
|
29.8
|
1.0
|
|
O3
|
E:BCT605
|
3.9
|
36.2
|
1.0
|
|
OD1
|
E:ASP294
|
4.0
|
29.1
|
1.0
|
|
C3
|
E:BES604
|
4.1
|
39.2
|
1.0
|
|
O3
|
E:BES604
|
4.1
|
38.6
|
1.0
|
|
CG
|
E:GLU373
|
4.3
|
30.4
|
1.0
|
|
CB
|
E:ASP312
|
4.3
|
29.5
|
1.0
|
|
O
|
E:THR401
|
4.3
|
27.2
|
1.0
|
|
C6
|
E:BES604
|
4.3
|
40.3
|
1.0
|
|
CD
|
E:LYS289
|
4.5
|
29.1
|
1.0
|
|
O
|
E:ASP371
|
4.7
|
33.5
|
1.0
|
|
CG2
|
E:ILE291
|
4.8
|
31.3
|
1.0
|
|
CB
|
E:ILE291
|
4.8
|
30.5
|
1.0
|
|
CG1
|
E:ILE291
|
4.9
|
29.8
|
1.0
|
|
OD1
|
E:ASP371
|
4.9
|
31.5
|
1.0
|
|
Reference:
J.Timm,
M.Valente,
D.Garcia-Caballero,
K.S.Wilson,
D.Gonzalez-Pacanowska.
Structural Characterization of Acidic M17 Leucine Aminopeptidases From the Tritryps and Evaluation of Their Role in Nutrient Starvation Intrypanosoma Brucei. Msphere V. 2 2018.
ISSN: ESSN 2379-5042
PubMed: 28815215
DOI: 10.1128/MSPHERE.00226-17
Page generated: Sun Oct 6 02:06:42 2024
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