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Manganese in PDB 5lyw: Crystal Structure of Human Methionine Aminopeptidase-2 in Complex; with An Inhibitor 6-((R)-2-O-Tolyloxymethyl-Pyrrolidin-1-Yl)-9H- Purine
Enzymatic activity of Crystal Structure of Human Methionine Aminopeptidase-2 in Complex; with An Inhibitor 6-((R)-2-O-Tolyloxymethyl-Pyrrolidin-1-Yl)-9H- Purine
All present enzymatic activity of Crystal Structure of Human Methionine Aminopeptidase-2 in Complex; with An Inhibitor 6-((R)-2-O-Tolyloxymethyl-Pyrrolidin-1-Yl)-9H- Purine:
3.4.11.18;
3.4.11.18;
Protein crystallography data
The structure of Crystal Structure of Human Methionine Aminopeptidase-2 in Complex; with An Inhibitor 6-((R)-2-O-Tolyloxymethyl-Pyrrolidin-1-Yl)-9H- Purine, PDB code: 5lyw
was solved by
D.Musil,
T.Heinrich,
T.Knoechel,
M.Lehmann,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 16.13 / 1.69 |
| Space group | C 2 2 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 89.780, 100.230, 100.380, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 17.1 / 19.3 |
Manganese Binding Sites:
The binding sites of Manganese atom in the Crystal Structure of Human Methionine Aminopeptidase-2 in Complex; with An Inhibitor 6-((R)-2-O-Tolyloxymethyl-Pyrrolidin-1-Yl)-9H- Purine
(pdb code 5lyw). This binding sites where shown within
5.0 Angstroms radius around Manganese atom.
In total 2 binding sites of Manganese where determined in the Crystal Structure of Human Methionine Aminopeptidase-2 in Complex; with An Inhibitor 6-((R)-2-O-Tolyloxymethyl-Pyrrolidin-1-Yl)-9H- Purine, PDB code: 5lyw:
Jump to Manganese binding site number: 1; 2;
In total 2 binding sites of Manganese where determined in the Crystal Structure of Human Methionine Aminopeptidase-2 in Complex; with An Inhibitor 6-((R)-2-O-Tolyloxymethyl-Pyrrolidin-1-Yl)-9H- Purine, PDB code: 5lyw:
Jump to Manganese binding site number: 1; 2;
Manganese binding site 1 out of 2 in 5lyw
Go back to
Manganese Binding Sites List in 5lyw
Manganese binding site 1 out
of 2 in the Crystal Structure of Human Methionine Aminopeptidase-2 in Complex; with An Inhibitor 6-((R)-2-O-Tolyloxymethyl-Pyrrolidin-1-Yl)-9H- Purine
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Manganese with other atoms in the Mn binding
site number 1 of Crystal Structure of Human Methionine Aminopeptidase-2 in Complex; with An Inhibitor 6-((R)-2-O-Tolyloxymethyl-Pyrrolidin-1-Yl)-9H- Purine within 5.0Å range:
|
Manganese binding site 2 out of 2 in 5lyw
Go back to
Manganese Binding Sites List in 5lyw
Manganese binding site 2 out
of 2 in the Crystal Structure of Human Methionine Aminopeptidase-2 in Complex; with An Inhibitor 6-((R)-2-O-Tolyloxymethyl-Pyrrolidin-1-Yl)-9H- Purine
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Manganese with other atoms in the Mn binding
site number 2 of Crystal Structure of Human Methionine Aminopeptidase-2 in Complex; with An Inhibitor 6-((R)-2-O-Tolyloxymethyl-Pyrrolidin-1-Yl)-9H- Purine within 5.0Å range:
|
Reference:
T.Heinrich,
H.P.Buchstaller,
B.Cezanne,
F.Rohdich,
J.Bomke,
M.Friese-Hamim,
M.Krier,
T.Knochel,
D.Musil,
B.Leuthner,
F.Zenke.
Novel Reversible Methionine Aminopeptidase-2 (Metap-2) Inhibitors Based on Purine and Related Bicyclic Templates. Bioorg. Med. Chem. Lett. V. 27 551 2017.
ISSN: ESSN 1464-3405
PubMed: 27998678
DOI: 10.1016/J.BMCL.2016.12.019
Page generated: Sun Oct 6 01:52:18 2024
ISSN: ESSN 1464-3405
PubMed: 27998678
DOI: 10.1016/J.BMCL.2016.12.019
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